2024
DOI: 10.1001/jamapsychiatry.2024.1429
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Major Psychiatric Disorders, Substance Use Behaviors, and Longevity

Daniel B. Rosoff,
Ali M. Hamandi,
Andrew S. Bell
et al.

Abstract: ImportanceObservational studies suggest that major psychiatric disorders and substance use behaviors reduce longevity, making it difficult to disentangle their relationships with aging-related outcomes.ObjectiveTo evaluate the associations between the genetic liabilities for major psychiatric disorders, substance use behaviors (smoking and alcohol consumption), and longevity.Design, Settings, and ParticipantsThis 2-sample mendelian randomization (MR) study assessed associations between psychiatric disorders, s… Show more

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