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Background. The study using numerical modeling of functional properties (conductive, distributive, pillar) of digital models of 4 types of bifurcations of the intraorgan arterial vasculature is a valuable tool to find its morphometric reference and subsequently the criterion of normality.Aim: To establish the functional properties of different types of splenic arterial bifurcations through their numerical modeling based on morphometry results.Material and Methods. Modelling was carried out on the basis of previously obtained morphometric characteristics of different types of splenic arterial bifurcations: type 1, the diameter of the parent (proximal) segment (D) is not equal to the diameters of the larger (dmax) and smaller (dmin) subsidiary branches (distal segments) D ≠ dmax ≠ dmin; type 2, D = dmax, D ≠ dmin; type 3, D ≠ dmax, dmin = dmax; type 4, D = dmax = dmin. The ANSYS Student computer software was used to calculate the values of splenic arterial bifurcation indices characterizing the conductive and support functions, and the Vasculograph computer software was used to calculate the distribution function.Results. It was found that the value of the bifurcation parameter of splenic arterial bifurcations of different types characterizing: 1) conductive function decreases in the order of type 1 complete asymmetry, type 2 lateral asymmetry, type 4 complete symmetry and type 3 unilateral symmetry; 2) the distributive function decreases in the direction of type 1 complete asymmetry, type 2 lateral asymmetry, type 3 unilateral symmetry, and type 4 complete symmetry 3) the pilar function decreases in the direction of type 1 complete asymmetry, type 2 lateral asymmetry, type 3 unilateral symmetry, and type 4 complete symmetry.Conclusion. The obtained results indicate that different types of splenic arterial bifurcations are oriented to fulfil heterogeneous functions. This should be taken into account when seeking a reference and subsequently a morphometric criterion of splenic vasculature norm, which can be used for radial diagnostics.
Background. The study using numerical modeling of functional properties (conductive, distributive, pillar) of digital models of 4 types of bifurcations of the intraorgan arterial vasculature is a valuable tool to find its morphometric reference and subsequently the criterion of normality.Aim: To establish the functional properties of different types of splenic arterial bifurcations through their numerical modeling based on morphometry results.Material and Methods. Modelling was carried out on the basis of previously obtained morphometric characteristics of different types of splenic arterial bifurcations: type 1, the diameter of the parent (proximal) segment (D) is not equal to the diameters of the larger (dmax) and smaller (dmin) subsidiary branches (distal segments) D ≠ dmax ≠ dmin; type 2, D = dmax, D ≠ dmin; type 3, D ≠ dmax, dmin = dmax; type 4, D = dmax = dmin. The ANSYS Student computer software was used to calculate the values of splenic arterial bifurcation indices characterizing the conductive and support functions, and the Vasculograph computer software was used to calculate the distribution function.Results. It was found that the value of the bifurcation parameter of splenic arterial bifurcations of different types characterizing: 1) conductive function decreases in the order of type 1 complete asymmetry, type 2 lateral asymmetry, type 4 complete symmetry and type 3 unilateral symmetry; 2) the distributive function decreases in the direction of type 1 complete asymmetry, type 2 lateral asymmetry, type 3 unilateral symmetry, and type 4 complete symmetry 3) the pilar function decreases in the direction of type 1 complete asymmetry, type 2 lateral asymmetry, type 3 unilateral symmetry, and type 4 complete symmetry.Conclusion. The obtained results indicate that different types of splenic arterial bifurcations are oriented to fulfil heterogeneous functions. This should be taken into account when seeking a reference and subsequently a morphometric criterion of splenic vasculature norm, which can be used for radial diagnostics.
The extracellular matrix (ECM) plays a central role in the structural integrity and functionality of the cardiovascular system. Moreover, the ECM is involved in atherosclerotic plaque formation and stability. In fact, ECM remodeling affects plaque stability, cellular migration, and inflammatory responses. Collagens, fibronectin, laminin, elastin, and proteoglycans are crucial proteins during atherosclerosis development. This dynamic remodeling is driven by proteolytic enzymes such as matrix metalloproteinases (MMPs), cathepsins, and serine proteases. Exploring and investigating ECM dynamics is an important step to designing innovative therapeutic strategies targeting ECM remodeling mechanisms, thus offering significant advantages in the management of cardiovascular diseases. This review illustrates the structure and role of vascular ECM, presenting a new perspective on ECM remodeling and its potential as a therapeutic target in atherosclerosis treatments.
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