We study Josephson junctions based on a second-order topological superconductor (SOTS) which is realized in a quantum spin Hall insulator with a large inverted gap in proximity to an unconventional superconductor. We find that tuning the chemical potential in the superconductor strongly modifies the pairing gap of the helical edge states and leads to topological phase transitions. As a result, the supercurrent in the junction is controllable and a 0-π transition is realized by tuning the chemical potentials in the superconducting leads. These striking features are stable in junctions with different sizes, doping in the normal region, and in the presence of disorder. We propose them as novel experimental signatures of SOTSs. Moreover, the 0-π transition can serve as a fully electric way to create or annihilate Majorana bound states in the junction without magnetic manipulation.Introduction.-The second-order topological superconductor (SOTS) is a novel topological phase of matter and features Majorana zero-dimensional (0D) corner or 1D hinge states which are two dimensions lower than the gapped bulk [1-12] and may provide stable qubits for topological quantum computation [13][14][15][16][17][18][19][20][21]. Recently, the SOTS has been discovered in a variety of realistic materials and triggered tremendous interest [3][4][5][6][7][8][9][10][22][23][24][25][26][27]. One way to mimic SOTSs in 2D is given by quantum spin Hall insulators (QSHIs) in proximity to unconventional superconductors with d x 2 −y 2 -wave or s ± -wave pairing order [3][4][5]. The proximity effect of unconventional superconductivity in 2D systems has also been intensively explored in theory [28][29][30][31][32][33][34][35][36][37] and experiment [38][39][40][41][42][43]. To date, however, the only way proposed to detect 2D SOTSs is a tunneling experiment without a concrete calculation of the observable signature. An alternative or complementary approach to probe SOTSs and manipulate the Majorana corner modes is thus desirable. In QSHIs, a finite doping is usually inevitable, and the chemical potential can be far away from the Dirac points. Therefore, it is interesting and relevant to explore the influence of the chemical potential in SOTSs.