We establish tighter uncertainty relations for arbitrary finite observables via (α, β, γ) weighted Wigner-Yanase-Dyson ((α, β, γ)WWYD) skew information. The results are also applicable to the (α, γ) weighted Wigner-Yanase-Dyson ((α, γ)WWYD) skew information and the weighted Wigner-Yanase-Dyson (WWYD) skew information. We also present tighter lower bounds of quantum channels and unitary channels via (α, β, γ) modified weighted Wigner-Yanase-Dyson ((α, β, γ)MWWYD) skew information. Detailed examples are provided to illustrate tightness of our uncertainty relations.