2023
DOI: 10.1002/ddr.22081
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mAKAPβ signalosome: A potential target for cardiac hypertrophy

Vaishnavi Golatkar,
Lokesh K. Bhatt

Abstract: Pathological cardiac hypertrophy is the result of a prolonged increase in the workload of the heart that activates various signaling pathways such as MAPK pathway, PKA‐dependent cAMP signaling, and CaN‐NFAT signaling pathway which further activates genes for cardiac remodeling. Various signalosomes are present in the heart that regulates the signaling of physiological and pathological cardiac hypertrophy. mAKAPβ is one such scaffold protein that regulates signaling pathways involved in promoting cardiac hypert… Show more

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