Making DEEP Sense of Lifestyle Risk and Resilience

Kempermann, Gerd

doi:10.3389/fnagi.2019.00171

Cited by 6 publications

(3 citation statements)

References 107 publications

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“…A similar pattern was observed in previous studies ( Mansens et al, 2018 ), but not in all ( Hanna-Pladdy and Gajewski, 2012 ; Gray and Gow, 2020 ). Together these variables may resemble a lifestyle that comprises various beneficial body and mind activities that could in synergy be associated with cognitive or brain reserve in late life ( Kempermann, 2019b , 2022 ). Notably though, we observed superior cognitive abilities in the musically active group with those reserve proxies accounted for by our one-to-one matching procedure.…”

Section: Discussionmentioning

confidence: 99%

Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults

et al. 2022

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Regular musical activity as a complex multimodal lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer’s disease. This cross-sectional study investigated the association and interplay between musical instrument playing during life, multi-domain cognitive abilities and brain morphology in older adults (OA) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Participants reporting having played a musical instrument across three life periods (n = 70) were compared to controls without a history of musical instrument playing (n = 70), well-matched for reserve proxies of education, intelligence, socioeconomic status and physical activity. Participants with musical activity outperformed controls in global cognition, working memory, executive functions, language, and visuospatial abilities, with no effects seen for learning and memory. The musically active group had greater gray matter volume in the somatosensory area, but did not differ from controls in higher-order frontal, temporal, or hippocampal volumes. However, the association between gray matter volume in distributed frontal-to-temporal regions and cognitive abilities was enhanced in participants with musical activity compared to controls. We show that playing a musical instrument during life relates to better late-life cognitive abilities and greater brain capacities in OA. Musical activity may serve as a multimodal enrichment strategy that could help preserve cognitive and brain health in late life. Longitudinal and interventional studies are needed to support this notion.

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Section: Discussionmentioning

confidence: 99%

Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults

et al. 2022

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“…To Table 1) assessing variables frequently related to age-related memory decline [70][71][72][73][74][75][76][77]. We also administered the original version of the Mnemonic Similarity Task [23,47], and we used two subtests from the Hungarian Wechsler Adult Intelligence Scale (WAIS-IV) [78], to assess processing speed (Digit-Symbol Substitution Test) and crystallized knowledge (Vocabulary Test).…”

Section: B Covariate Assessmentsmentioning

confidence: 99%

Discrimination of semantically similar verbal memory traces is affected in healthy aging

Ilyes,

Paulik,

Keresztes

2023

Preprint

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Fluid cognitive abilities are affected in healthy aging via various changes in neural operations, while crystallized knowledge representations remain relatively intact. Yet, a few recent studies have suggested that age-related changes in fluid abilities may influence the access, manipulation, and processing of crystallized knowledge. For instance, mnemonic discrimination of highly similar memory traces, a key fluid ability supporting memory specificity, shows a clear age-related decline. However, the scope of this decline is not yet fully understood, as previous studies have often confounded operations and representations by almost exclusively testing mnemonic discrimination of visuospatial stimuli (e.g., objects or scenes). To address this gap, we designed a task to assess mnemonic discrimination of verbal stimuli as a function of semantic similarity. We manipulated similarity based on a Hungarian word-embedding which models semantic relationships between words. Forty young (Mage = 21.7 years) and 40 old adults (Mage = 69.8 years) first incidentally encoded adjective-noun phrases, then performed a surprise recognition test involving the same phrases as well as highly similar lures. We found that increasing semantic similarity negatively affected mnemonic discrimination in both age groups, and that compared to young adults, older adults showed worse discrimination and differential sensitivity to similarity independent of crystallized knowledge. These results indicate that specificity of semantic memory traces is affected in aging via less efficient mnemonic operations, and strengthen the notion that changes in fluid abilities in healthy aging influence the use of crystallized knowledge.

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“…Taking care of the brain in the early stages of life is preferable as early and mid-life factors influence late-life cognitive and mental health ( 30 ) and many brain diseases are not treatable or curable. For instance, despite efforts to cure Alzheimer's disease so far not yielding the desired success, several avenues related to lifestyle factors during mid-life have been identified to potentially delay disease manifestation ( 28 , 31 ).…”

Section: Introductionmentioning

confidence: 99%

The Global Brain Health Survey: Development of a Multi-Language Survey of Public Views on Brain Health

Budin‐Ljøsne

Friedman

Suri

et al. 2020

Front. Public Health

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Background: Brain health is a multi-faceted concept used to describe brain physiology, cognitive function, mental health and well-being. Diseases of the brain account for one third of the global burden of disease and are becoming more prevalent as populations age. Diet, social interaction as well as physical and cognitive activity are lifestyle factors that can potentially influence facets of brain health. Yet, there is limited knowledge about the population's awareness of brain health and willingness to change lifestyle to maintain a healthy brain. This paper introduces the Global Brain Health Survey protocol, designed to assess people's perceptions of brain health and factors influencing brain health. Methods: The Global Brain Health Survey is an anonymous online questionnaire available in 14 languages to anyone above the age of 18 years. Questions focus on (1) willingness and motivation to maintain or improve brain health, (2) interest in learning more about individual brain health using standardized tests, and (3) interest in receiving individualized support to take care of own brain health. The survey questions were developed based on results from a qualitative interview study investigating brain Budin-Ljøsne et al. Global Brain Health Survey health perceptions among participants in brain research studies. The survey includes 28 questions and takes 15-20 min to complete. Participants provide electronically informed consent prior to participation. The current survey wave was launched on June 4, 2019 and will close on August 31, 2020. We will provide descriptive statistics of samples distributions including analyses of differences as a function of age, gender, education, country of residence, and we will examine associations between items. The European Union funded Lifebrain project leads the survey in collaboration with national brain councils in Norway, Germany, and Belgium, Brain Foundations in the Netherlands and Sweden, the National University of Ostroh Academy and the Women's Brain Project. Discussion: Results from this survey will provide new insights in peoples' views on brain health, in particular, the extent to which the adoption of positive behaviors can be encouraged. The results will contribute to the development of policy recommendations for supporting population brain health, including measures tailored to individual needs, knowledge, motivations and life situations.

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Making DEEP Sense of Lifestyle Risk and Resilience

Cited by 6 publications

References 107 publications

Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults

Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults

Discrimination of semantically similar verbal memory traces is affected in healthy aging

The Global Brain Health Survey: Development of a Multi-Language Survey of Public Views on Brain Health

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