Making light work: illuminating the future of biomedical optics

Elwell, Clare E.; Cooper, Chris E.

doi:10.1098/rsta.2011.0302

Cited by 65 publications

(26 citation statements)

References 53 publications

(81 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NIR spectroscopy and DRS have been extensively used for in vivo detection up to a few centimetres in tissues 43 44 . As a general principle, the mean light penetration depth in the reflection geometry is in the order of the half the distance between source and detector fibers 43 .…”

Section: Discussionmentioning

confidence: 99%

Diffuse Optical Spectroscopy and Imaging to Detect and Quantify Adipose Tissue Browning

Dinish

Wong

Sriram

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Adipose (fat) tissue is a complex metabolic organ that is highly active and essential. In contrast to white adipose tissue (WAT), brown adipose tissue (BAT) is deemed metabolically beneficial because of its ability to burn calories through heat production. The conversion of WAT-resident adipocytes to “beige” or “brown-like” adipocytes has recently attracted attention. However, it typically takes a few days to analyze and confirm this browning of WAT through conventional molecular, biochemical, or histological methods. Moreover, accurate quantification of the overall browning process is not possible by any of these methods. In this context, we report the novel application of diffuse reflectance spectroscopy (DRS) and multispectral imaging (MSI) to detect and quantify the browning process in mice. We successfully demonstrated the time-dependent increase in browning of WAT, following its induction through β-adrenergic agonist injections. The results from these optical techniques were confirmed with those of standard molecular and biochemical assays, which measure gene and protein expression levels of UCP1 and PGC-1α, as well as with histological examinations. We envision that the reported optical methods can be developed into a fast, real time, cost effective and easy to implement imaging approach for quantification of the browning process in adipose tissue.

show abstract

Section: Discussionmentioning

confidence: 99%

Diffuse Optical Spectroscopy and Imaging to Detect and Quantify Adipose Tissue Browning

Dinish

Wong

Sriram

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…At present there are no universally adopted methods for the data analysis used in the production of topographical maps, or even agreement about determining the statistical significance of hemodynamic changes (Elwell and Cooper, 2011). Further, papers do not always present both oxy- and deoxy-Hb, despite evidence that that they should be equally valued as markers of cerebral oxygenation, and should therefore be reported together as standard.…”

Section: Methodological Limitations and Future Recommendationsmentioning

confidence: 99%

The application of near infrared spectroscopy in nutritional intervention studies

Jackson¹,

Kennedy²

2013

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Functional near infrared spectroscopy (NIRS) is a non-invasive optical imaging technique used to monitor cerebral blood flow (CBF) and by proxy neuronal activation. The use of NIRS in nutritional intervention studies is a relatively novel application of this technique, with only a small, but growing, number of trials published to date. These trials—in which the effects on CBF following administration of dietary components such as caffeine, polyphenols and omega-3 polyunsaturated fatty acids are assessed—have successfully demonstrated NIRS as a sensitive measure of change in hemodynamic response during cognitive tasks in both acute and chronic treatment intervention paradigms. The existent research in this area has been limited by the constraints of the technique itself however advancements in the measurement technology, paired with studies endeavoring increased sophistication in number and locations of channels over the head should render the use of NIRS in nutritional interventions particularly valuable in advancing our understanding of the effects of nutrients and dietary components on the brain.

show abstract

“…In addition, in the field of exercise science, NIRS systems with LED sources (e.g., SRS-NIRS) are more suitable because they allow smaller and portable instrumentation and are safer in their application, as compared to NIRS systems with laser sources (e.g., FD-NIRS and TD-NIRS) [ 171 , 189 ]. More detailed information about the differences between CW-NIRS, SRS-NIRS, FD-NIRS, and TD-NIRS can be found in the referenced literature [ 98 , 171 , 174 , 180 , 181 , 183 , 185 , 186 , 190 , 191 , 192 , 193 , 194 , 195 , 196 ].…”

Section: Neurophysiological Mechanisms and Physical Principles Of mentioning

confidence: 99%

New Directions in Exercise Prescription: Is There a Role for Brain-Derived Parameters Obtained by Functional Near-Infrared Spectroscopy?

et al. 2020

View full text Add to dashboard Cite

In the literature, it is well established that regular physical exercise is a powerful strategy to promote brain health and to improve cognitive performance. However, exact knowledge about which exercise prescription would be optimal in the setting of exercise–cognition science is lacking. While there is a strong theoretical rationale for using indicators of internal load (e.g., heart rate) in exercise prescription, the most suitable parameters have yet to be determined. In this perspective article, we discuss the role of brain-derived parameters (e.g., brain activity) as valuable indicators of internal load which can be beneficial for individualizing the exercise prescription in exercise–cognition research. Therefore, we focus on the application of functional near-infrared spectroscopy (fNIRS), since this neuroimaging modality provides specific advantages, making it well suited for monitoring cortical hemodynamics as a proxy of brain activity during physical exercise.

show abstract

Making light work: illuminating the future of biomedical optics

Cited by 65 publications

References 53 publications

Diffuse Optical Spectroscopy and Imaging to Detect and Quantify Adipose Tissue Browning

Diffuse Optical Spectroscopy and Imaging to Detect and Quantify Adipose Tissue Browning

The application of near infrared spectroscopy in nutritional intervention studies

New Directions in Exercise Prescription: Is There a Role for Brain-Derived Parameters Obtained by Functional Near-Infrared Spectroscopy?

Contact Info

Product

Resources

About