Making room for oxytocin in understanding depression

McQuaid, Robyn J.; McInnis, Opal A.; Abizaid, Alfonso; Anisman, Hymie

doi:10.1016/j.neubiorev.2014.07.005

Cited by 148 publications

(124 citation statements)

References 266 publications

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“…ELS-associated maternal depression can therefore be considered a main pathway of the intergenerational transmission of maternal ELS in humans. Given the co-occurrence of maternal depression and impaired parenting, one may speculate that they share common biological underpinnings, likely including OT neural circuits, which have recently been suggested to play an etiologically relevant role in depression (McQuaid et al, 2014). Therefore, the following section will highlight the role of OT pathways in modulation of biological processes that underlie major depression (MDD)/PPD, with a particular focus on the hypothalamic pituitary adrenal (HPA) axis and the immune system.…”

Section: Ot and Early-life Stress (Els) – Role In Shaping Neural Cmentioning

confidence: 99%

“…For example, administration of OT significantly attenuates lipopolysaccharide-induced production of pro-inflammatory cytokines tumor necrosis factor alpha ( TNF-α) and interleukin 6 ( IL-6) in serum of healthy human subjects (Clodi et al, 2008) and microglial production of TNF-α and interleukin 1 beta (IL-1β) in mice (Yuan et al, 2016). Considering its anti-inflammatory effects and growing evidence that inflammatory cytokines are involved in the etiology of MDD and PPD, it can be hypothesized that insufficient OT signaling may contribute to depression risk via this pathway (McQuaid et al, 2014). Consistent with this view, socially isolated mice that were treated with OT showed reduced levels of depressive-like behavior and lower expression of IL-1β in the frontal cortex after induction of a nerve injury compared to isolated animals without OT treatment (Norman et al, 2010).…”

Section: Ot and Early-life Stress (Els) – Role In Shaping Neural Cmentioning

confidence: 99%

“…Likewise, an OTR antagonist blocked the antidepressant and anti-inflammatory effects of social housing in non-isolated animals. To our knowledge, no study has yet investigated interactions of OT and inflammatory markers in humans in the context of MDD or PPD directly but this may be a pathway worth further investigating in future studies (Garfield et al, 2015; McQuaid et al, 2014). …”

Section: Ot and Early-life Stress (Els) – Role In Shaping Neural Cmentioning

confidence: 99%

“…This suggests that central availability and functioning of the OT system may be susceptible to environmental factors such as ELS, which persist into adulthood and may impact functional integrity of the “parental brain”. It is also suggested that OT may play an important role in the development of depression (McQuaid et al, 2014), which is a highly prevalent clinical consequence of ELS and a condition that may interfere with optimal parenting behavior (Beck, 1995; Feldman, 2015b; Field, 2010). Finally, OT modulates the activity of stress-sensitive biological systems, such as the HPA-axis (Cardoso et al, 2014) and the immune system (Wang et al, 2015), which have been previously proposed to affect fetal development (Entringer et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Oxytocin pathways in the intergenerational transmission of maternal early life stress

Toepfer

Heim

Entringer

et al. 2017

Neuroscience & Biobehavioral Reviews

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Severe stress in early life, such as childhood abuse and neglect, constitutes a major risk factor in the etiology of psychiatric disorders and somatic diseases. Importantly, these long-term effects may impact the next generation. The intergenerational transmission of maternal early life stress (ELS) may occur via pre-and postnatal pathways, such as alterations in maternal-fetal-placental stress physiology, maternal depression during pregnancy and postpartum, as well as impaired mother-offspring interactions. The neuropeptide oxytocin (OT) has gained considerable attention for its role in modulating all of these assumed transmission pathways. Moreover, central and peripheral OT signaling pathways are highly sensitive to environmental exposures and may be compromised by ELS with implications for these putative transmission mechanisms. Together, these data suggest that OT pathways play an important role in the intergenerational transmission of maternal ELS in humans. By integrating recent studies on gene-environment interactions and epigenetic modifications in OT pathway genes, the present review aims to develop a conceptual framework of intergenerational transmission of maternal ELS that emphasizes the role of OT.

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Section: Ot and Early-life Stress (Els) – Role In Shaping Neural Cmentioning

confidence: 99%

Section: Ot and Early-life Stress (Els) – Role In Shaping Neural Cmentioning

confidence: 99%

Section: Ot and Early-life Stress (Els) – Role In Shaping Neural Cmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Toepfer

Heim

Entringer

et al. 2017

Neuroscience & Biobehavioral Reviews

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“…Estos resultados indicarían que la separación materna durante la lactancia afectó las concentraciones de oxitocina, sobre todo en la etapa adulta y, en mayor grado, en las hembras. Los hallazgos respaldan el planteamiento de que, dada su importancia en una serie de comportamientos sociales positivos como la interacción materno-infantil, en animales adultos la oxitocina puede facilitar las interacciones sociales selectivas asociadas con la afinidad entre individuos y la formación de parejas, y participar en la regulación de las funciones parasimpáticas (36).…”

Section: Oxitocinaunclassified

La separación materna durante la lactancia altera los niveles basales neuroendocrinos en ratas adolescentes y adultas

Riveros-Barrera

Dueñas

2015

biomedica

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: diseño del proyecto y los experimentos, y entrenamiento de Irene Riveros-Barrera Irene Riveros-Barrera: desarrollo de todos los experimentos Las dos autoras participaron en el análisis de datos y en la escritura del manuscrito. La separación materna durante la lactancia altera los niveles basales del sistema neuroendocrino en ratas adolescentes y adultasIrene Riveros-Barrera, Zulma DueñasDepartamento de Ciencias Fisiológicas, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, D.C., ColombiaIntroducción. En diversos modelos animales, incluido el de la separación materna durante la lactancia, se ha demostrado que las experiencias tempranas adversas, como el maltrato, el abandono materno y el estrés psicosocial, pueden favorecer el desarrollo de algunas enfermedades mentales, pero no se han descrito completamente varios de los cambios que se producen en el sistema neuroendocrino. Objetivo. Determinar si la separación materna durante la lactancia modificaba los niveles basales de neurohormonas como la corticosterona, la corticotropina (ACTH), la oxitocina y la vasopresina (ADH), en ratas jóvenes (35 días) y adultas (90 días). Materiales y métodos. Se separaron ratas Wistar de sus madres durante dos periodos de tres horas diarias a lo largo de los 21 días de lactancia. A los 35 y 90 días se tomaron muestras de los grupos de las ratas de control y de las separadas de la madre, para obtener el suero y posteriormente medir cada una de las hormonas mediante un ensayo inmunoenzimático.Resultados. Las concentraciones de corticosterona fueron mayores en las hembras adultas de control que en el resto de los grupos, y menores en los machos adultos de control. Las de ACTH fueron mayores en los machos y hembras jóvenes separadas de la madre que en los grupos de adultos. Los niveles de oxitocina fueron significativamente mayores en las hembras adultas separadas de la madre que en los otros grupos y significativamente menores en los machos adultos. En cuanto a la vasopresina, los grupos separados de la madre tuvieron concentraciones menores, en comparación con los grupos de jóvenes y adultos de control. Conclusiones. Estos resultados muestran que el estrés temprano al que fueron sometidas las ratas, produjo cambios en las respuestas del eje hipotálamo-hipófisis-suprarrenal, las cuales variaron según el sexo y la edad.Palabras clave: lactancia materna, relación madre-hijo, corticosterona, hormona liberadora de corticotropina, oxitocina, arginina vasopresina, sistema hipófiso-suprarrenal.doi: http://dx.doi.org/10.7705/biomedica.v36i1.2830Maternal separation during nursing alters basal neuroendocrine levels in juvenile and adult rats Introduction: Work with different animal models including that of maternal separation during nursing has shown that early adverse experiences such as abuse, maternal abandonment and psychosocial stress may favor the development of various psychopathologies. However, several neuroendocrine changes have not been completely described yet. Objective: To establish whether maternal separation d...

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Depression in early adolescence: Contributions from relational aggression and variation in the oxytocin receptor gene

Kushner¹,

Herzhoff

Vrshek‐Schallhorn

et al. 2017

Aggressive Behavior

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Interpersonal stress arising from relational aggression (RA)-the intentional effort to harm others via rejection and exclusion-may increase risk for depression in youth. Biological vulnerabilities related to the hormone oxytocin, which affects social behavior and stress responses, may exacerbate this risk. In a community sample of 307 youth (52% female; age range = 10-14 years), we tested whether (1) the association between RA and subsequent depressive symptoms was mediated through social problems and (2) a single nucleotide polymorphism (rs53576) in the oxytocin receptor gene (OXTR) moderated this indirect association between RA and depression, where GG homozygotes are predicted to be more sensitive to the effects of social problems than A-allele carriers. Youth-reported RA and depressive symptoms were measured using a structured interview and a questionnaire, respectively. DNA was extracted from saliva collected with Oragene kits. Consistent with the interpersonal theory of depression, the association between relational aggression and subsequent depressive symptoms was mediated by social problems. This indirect effect was further moderated by rs53576 genotype, such that GG homozygotes showed a stronger mediation effect than A-carriers. These results suggest that rs53576 variants confer vulnerability for depression within the context of interpersonal risk factors, such that youth with the GG genotype may be particularly sensitive to the social consequences resulting from RA.

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Making room for oxytocin in understanding depression

Cited by 148 publications

References 266 publications

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Oxytocin pathways in the intergenerational transmission of maternal early life stress

La separación materna durante la lactancia altera los niveles basales neuroendocrinos en ratas adolescentes y adultas

Depression in early adolescence: Contributions from relational aggression and variation in the oxytocin receptor gene

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