Making sense of flavivirus non-strctural protein 1 in innate immune evasion and inducing tissue-specific damage

Zeng, Quan; Liu, Jiaqi; Hao, Chenlin; Zhang, Bo; Zhang, Honglei

doi:10.1016/j.virusres.2023.199222

Virus Research

2023

DOI: 10.1016/j.virusres.2023.199222

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Making sense of flavivirus non-strctural protein 1 in innate immune evasion and inducing tissue-specific damage

Quan Zeng,

Jiaqi Liu,

Chenlin Hao

et al.

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2024

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Cited by 3 publications

References 78 publications

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Repurposing of FDA-approved drugs against oligomerization domain of dengue virus NS1 protein: a computational approach

Chaudhuri,

Ghosh,

Majumder

et al. 2024

Mol Divers

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Repurposing of FDA-approved drugs against oligomerization domain of dengue virus NS1 protein: a computational approach

Chaudhuri,

Ghosh,

Majumder

et al. 2024

Mol Divers

View full text Add to dashboard Cite

Diagnosing arthropod-borne flaviviruses: non-structural protein 1 (NS1) as a biomarker

Ceconi,

Ariën,

Delputte

2024

Trends in Microbiology

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The NS1 protein of contemporary West African Zika virus potentiates viral replication and reduces innate immune activation

Machmouchi,

Courageot,

Ogire

et al. 2024

PLoS Negl Trop Dis

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Mosquito-borne Zika virus (ZIKV) from sub-Saharan Africa has recently gained attention due to its epidemic potential and its capacity to be highly teratogenic. To improve our knowledge on currently circulating strains of African ZIKV, we conducted protein sequence alignment and identified contemporary West Africa NS1 (NS1CWA) protein as a highly conserved viral protein. Comparison of NS1CWA with the NS1 of the historical African ZIKV strain MR766 (NS1MR766), revealed seven amino acid substitutions. The effects of NS1 mutations on protein expression, virus replication, and innate immune activation were assessed in human cells using recombinant NS1 proteins and a chimeric viral clone MR766 with NS1CWA replacing NS1MR766. Our data indicated higher secretion efficiency of NS1CWA compared to NS1MR766 associated with a change in subcellular distribution. A chimeric MR766 virus with NS1CWA instead of authentic protein displayed a greater viral replication efficiency, leading to more pronounced cell death compared to parental virus. Enhanced viral growth was associated with reduced activation of innate immunity. Our data raise questions of the importance of NS1 protein in the pathogenicity of contemporary ZIKV from sub-Saharan Africa and point to differences within viral strains of African lineage.

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Making sense of flavivirus non-strctural protein 1 in innate immune evasion and inducing tissue-specific damage

Cited by 3 publications

References 78 publications

Repurposing of FDA-approved drugs against oligomerization domain of dengue virus NS1 protein: a computational approach

Repurposing of FDA-approved drugs against oligomerization domain of dengue virus NS1 protein: a computational approach

Diagnosing arthropod-borne flaviviruses: non-structural protein 1 (NS1) as a biomarker

The NS1 protein of contemporary West African Zika virus potentiates viral replication and reduces innate immune activation

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