Making sense of post-treatment surveillance in head and neck cancer: when and what of follow-up

Manikantan, Kapila; Khode, Shailesh; Dwivedi, Raghav C.; Palav, Rajan; Nutting, Chris; Rhys-Evans, Peter; Harrington, Kevin; Kazi, Rehan

doi:10.1016/j.ctrv.2009.08.007

Cited by 102 publications

(98 citation statements)

References 52 publications

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“…Physical examination performed by an experienced clinician, fiber-optic endoscopy, fine needle aspiration biopsy (FNAB)/core biopsy, and, if necessary, additional biopsies under anesthesia are required to diagnose and stage HNT [3]. Cervical lymph node metastasis has a great impact on the prognosis of HNT [4].…”

Section: Introductionmentioning

confidence: 99%

Supraclavicular Lymphadenopathy: Should It Be Perceived as the Virchow's Node of Head and Neck Tumors?

Acar

Savas²,

Kocacelebi

et al. 2014

Oncol Res Treat

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Background: In this study, we aimed to determine the correlation between supraclavicular lymph node involvement (SLNI) and metastatic potential, frequency, and metastases predilection sites in patients diagnosed with various head and neck tumors (HNT) and staged via positron emission tomography/computed tomography (PET/CT) imaging. We also investigated the impact of different variables on SLNI. Patients and Methods: 270 patients diagnosed with HNT were enrolled in the study (194 males and 96 females, mean age 54.9 ± 14.7 years (range 18-89 years)). Results: Nasopharyngeal carcinoma demonstrated significant SLNI (p < 0.01); however, other subtypes of HNT did not. In all HNT studied, no apparent metastatic predilection tendency for the supraclavicular region was observed, as opposed to the well-described Virchow's node. Age, gender, tumor size, and systemic metastases were not identified as statistically significant variables contributing to SLNI. Multivariate regression analysis revealed an increased cervical (p < 0.01) and thoracic (p = 0.001) lymph node involvement in patients with SLNI. Conclusion: SLNI with the possibility of metastasis was more frequently observed in nasopharyngeal carcinoma, advancing the nodal status without significantly influencing the T and M stages. A careful evaluation of this very small region is of critical importance for proper nodal staging in nasopharyngeal cancer patients.

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Section: Introductionmentioning

confidence: 99%

Supraclavicular Lymphadenopathy: Should It Be Perceived as the Virchow's Node of Head and Neck Tumors?

Acar

Savas²,

Kocacelebi

et al. 2014

Oncol Res Treat

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“…Long-termfollow-upafterradicalRTforHNCaimstoevaluate treatment response, manage toxicity, exclude persistent disease, detect locoregional recurrence, monitor for distant metastases (DM) and diagnose second primary tumors [26]. Thereisnoclearconsensusintheliteratureontheoptimum frequency and modality of follow-up imaging.…”

Section: Applications Of Imaging: Follow-upmentioning

confidence: 99%

“…Thereisnoclearconsensusintheliteratureontheoptimum frequency and modality of follow-up imaging. Published surveillance protocols often lack a clear evidence base and canberesourceintensive [26].…”

Section: Applications Of Imaging: Follow-upmentioning

confidence: 99%

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Radiotherapy for Head and Neck Cancer: An Increasing Dependence on Innovative Imaging

Nuyts¹,

Fairchild²

2012

Onkologie

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Technical improvements in computed tomography and magnetic resonance imaging as well as the wider availability of biological imaging have facilitated the implementation of high-precision 3-dimensional conformal and intensity-modulated radiotherapy (RT) in head and neck cancer. The integration of recent advances in functional and molecular imaging has already improved RT delivery, response prediction, and follow-up. Rational clinical use of all modalities should be encouraged, especially in the setting of imaging-intensive investigational RT protocols such as adaptive therapy. An expanded development of imaging markers that can predict radioresistance or outcome could further customize treatment. The continued successful use of innovative imaging in routine clinical practice will ultimately depend on well-designed clinical studies with adequate follow-up.

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“…Research into follow-up strategies for head-and-neck cancer has not shown an advantage in overall survival with routine cancer surveillance for timely detection of recurrence [5][6][7][8][9][10] , and no randomized clinical trials have compared follow-up strategies with no follow-up 11 . The literature pertaining to how follow-up care can most effectively manage morbidity and address other health needs in head-and-neck cancer patients is limited 12,13 .…”

Section: Introductionmentioning

confidence: 99%

Variation in Routine Follow-Up Care After Curative Treatment for Head-and-Neck Cancer: A Population-Based Study in Ontario

et al. 2018

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Making sense of post-treatment surveillance in head and neck cancer: when and what of follow-up

Cited by 102 publications

References 52 publications

Supraclavicular Lymphadenopathy: Should It Be Perceived as the Virchow's Node of Head and Neck Tumors?

Supraclavicular Lymphadenopathy: Should It Be Perceived as the Virchow's Node of Head and Neck Tumors?

Radiotherapy for Head and Neck Cancer: An Increasing Dependence on Innovative Imaging

Variation in Routine Follow-Up Care After Curative Treatment for Head-and-Neck Cancer: A Population-Based Study in Ontario

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