Making sense of sensory evidence in the rat whisker system

Fassihi, Arash; Zuo, Yangfang; Diamond, Mathew E.

doi:10.1016/j.conb.2019.11.012

Cited by 9 publications

(13 citation statements)

References 36 publications

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“…Neurons in rat somatosensory cortex precisely encode instantaneous speed [7], and analogous coding mechanisms exist in primates [10]. Because the vibration was stochastic, no instantaneous value could provide an intensity estimate for the PLOS COMPUTATIONAL BIOLOGY entire vibration [11]. A subject could, in theory, achieve optimal performance in the intensity task by linearly integrating (summating) the output of I-coding neurons over the entire vibration and then normalizing the integrated value by elapsed time.…”

Section: Experiments 3: a Sensory Integration Account For Time And Intensity Perceptionmentioning

confidence: 99%

“…We speculate, however, that rats also simultaneously experience two distinct percepts, an assumption that would require discrete brain populations to simultaneously integrate sensory drive with different time constants. Primary somatosensory cortex is characterized by a short intrinsic timescale, and does not show temporal integration [7,11,29,50,52]. Intrinsic timescales for intensity integration may be found in primary and secondary vibrissal motor cortex (vM1 and vM2) and intrinsic timescales for duration integration may be found in farther anterior or medial regions.…”

Section: Integration Timescales Point To Target Regions and Mechanismsmentioning

confidence: 99%

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A sensory integration account for time perception

et al. 2021

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The connection between stimulus perception and time perception remains unknown. The present study combines human and rat psychophysics with sensory cortical neuronal firing to construct a computational model for the percept of elapsed time embedded within sense of touch. When subjects judged the duration of a vibration applied to the fingertip (human) or whiskers (rat), increasing stimulus intensity led to increasing perceived duration. Symmetrically, increasing vibration duration led to increasing perceived intensity. We modeled real spike trains recorded from vibrissal somatosensory cortex as input to dual leaky integrators–an intensity integrator with short time constant and a duration integrator with long time constant–generating neurometric functions that replicated the actual psychophysical functions of rats. Returning to human psychophysics, we then confirmed specific predictions of the dual leaky integrator model. This study offers a framework, based on sensory coding and subsequent accumulation of sensory drive, to account for how a feeling of the passage of time accompanies the tactile sensory experience.

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Section: Experiments 3: a Sensory Integration Account For Time And Intensity Perceptionmentioning

confidence: 99%

Section: Integration Timescales Point To Target Regions and Mechanismsmentioning

confidence: 99%

A sensory integration account for time perception

et al. 2021

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“…At the sensory periphery neurons encode moment-to-moment sensory input whereas high-order brain structures encode object identity persistently and often with spatial invariance. Barrel cortex, an intermediate stage in this process, can be driven by extreme <5 ms synchrony (Bruno and Sakmann, 2006), the previous ~50 ms of sensory input (Bale and Maravall, 2018;Fassihi et al, 2020;Ramirez et al, 2014), whisker motor movements at ~100 ms (Fee et al, 1997), and even task-related features like reward over >1 s timescales (Lacefield et al, 2019).…”

Section: Timescales Of Integration In Barrel Cortex and Beyondmentioning

confidence: 99%

The sensorimotor strategies and neuronal representations of tactile shape discrimination in mice

Rodgers

Nogueira

Pil

et al. 2020

Preprint

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14Humans and other animals can identify objects by active touch, requiring the coordination of exploratory 15 motion and tactile sensation. The brain integrates movements with the resulting tactile signals to form a 16 holistic representation of object identity. We developed a shape discrimination task that challenged head-17 fixed mice to discriminate concave from convex shapes. Behavioral decoding revealed that mice did this 18 by comparing contacts across whiskers. In contrast, mice performing a shape detection task simply 19 summed up contacts over whiskers. We recorded populations of neurons in the barrel cortex, which 20 processes whisker input, to identify how it encoded the corresponding sensorimotor variables. Neurons 21 across the cortical layers encoded touch, whisker motion, and task-related signals. Sensory 22 representations were task-specific: during shape discrimination, neurons responded most robustly to 23 behaviorally relevant whiskers, overriding somatotopy. We suggest a similar dynamic modulation may 24

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“…Neurons in rat somatosensory cortex precisely encode instantaneous speed 7, and analogous coding mechanisms exist in primates (9). Because the vibration was stochastic, no instantaneous value could provide an intensity estimate for the entire vibration (10). A subject could, in theory, achieve optimal performance in the intensity task by linearly integrating (summating) the output of speed-coding neurons over the entire vibration and then normalizing the integrated value…”

Section: Experiments 3: a Sensory Integration Account For Time And Intmentioning

confidence: 99%

“…Primary somatosensory cortex is characterized by a short intrinsic timescale, and does not show temporal integration (7,10,28,47,49). Intrinsic timescales for intensity integration may be found in primary and secondary vibrissal motor cortex (vM1 and vM2) and intrinsic timescales for duration integration may be found in farther anterior or medial regions.…”

Section: Integration Timescales Point To Target Regions and Mechanismsmentioning

confidence: 99%

A sensory integration account for time perception

Toso

Fassihi

Paz

et al. 2020

Preprint

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The connection between stimulus perception and time perception remains unknown. The present study combines human and rat psychophysics with sensory cortical neuronal firing to construct a computational model for the percept of elapsed time embedded within sense of touch. When subjects judged the duration of a vibration applied to the fingertip (human) or whiskers (rat), increasing stimulus mean speed led to increasing perceived duration. Symmetrically, increasing vibration duration led to increasing perceived intensity. We modeled spike trains from vibrissal somatosensory cortex as input to dual leaky integrators – an intensity integrator with short time constant and a duration integrator with long time constant – generating neurometric functions that replicated the actual psychophysical functions of rats. Returning to human psychophysics, we then confirmed specific predictions of the dual leaky integrator model. This study offers a framework, based on sensory coding and subsequent accumulation of sensory drive, to account for how a feeling of the passage of time accompanies the tactile sensory experience.

show abstract

Making sense of sensory evidence in the rat whisker system

Cited by 9 publications

References 36 publications

A sensory integration account for time perception

A sensory integration account for time perception

The sensorimotor strategies and neuronal representations of tactile shape discrimination in mice

A sensory integration account for time perception

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