Makulaveränderungen bei Grubenpapille – „Optic disc pit maculopathy“ (ODP-M)

Wachtlin, Joachim; Schumann, Ricarda G.; Maier, Mathias; Haritoglou, Christos

doi:10.1007/s00347-019-0933-z

Cited by 5 publications

(1 citation statement)

References 26 publications

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“…There are several controversial suggestions about the origin of subretinal fluid such as cerebrospinal fluid, liquefied vitreous entering through the pit or through a macular hole, and leakage from either choroidal vessels or permeable vessels in the pit [5,6,8]. Various therapeutic approaches have been proposed such as laser coagulation of the retina, macula buckling, and pars plana vitrectomy (PPV) combined with further surgical steps [5,[9][10][11][12][13][14]. The goal of every approach is to eliminate the sub-and intraretinal fluid and also to seal the hypothetical communication between the vitreous cavity and the subretinal space as it is known, that subretinal fluid leads to a decrease of best-corrected visual acuity (BCVA) over time [15].…”

Section: Introductionmentioning

confidence: 99%

Long-term outcomes of autologous platelet treatment for optic disc pit maculopathy

Gklavas

Athanasiou

Neubauer

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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Purpose Optic disc pits (ODPs) are rare congenital cavitary abnormalities of the optic nerve head, which can lead to serous macular detachments. The aim of this study was to evaluate the long-term efficacy of pars plana vitrectomy (PPV) combined with autologous platelet concentrate (APC) for the treatment of optic disc pit maculopathy (ODP-M). Methods A retrospective analysis was performed on eleven eyes of ten patients with ODP-M, who received PPV combined with APC. Nine eyes operated primary, four of which had a repeat surgery also with injection of APC and two eyes underwent a rescue surgery, after they have been operated in another eye center without APC. Morphological and functional results were the main outcome parameters, determined by optical coherence tomography (OCT) and best-corrected visual acuity (BCVA), respectively. Results The mean duration of visual loss before surgery was 4.7 ± 3.89 months (range 0–12 months). The mean BCVA increased significantly from 0.82 ± 0.33 logMAR (range 0.4–1.3) preoperatively to 0.51 ± 0.36 logMAR (range 0–1.2) at the last examination (p = 0.0022). A significant morphological improvement was also noticed with decrease of the mean foveal thickness from 935.82 ± 248.48 µm (range 559–1400 µm) preoperatively to 226.45 ± 76.09 µm (range 110–344 µm) at the final examination (p < 0.0001). The patients were followed-up for a mean 65.36 ± 48.81 months (range 1–144 months). Two eyes developed postoperatively a retinal detachment. Cataract surgery was performed in 5 eyes during the follow-up period. Conclusion Our study demonstrated that PPV with APC can improve functional and morphological outcomes, both as a primary and a rescue therapy, without any recurrence over a long follow-up period. To the best of our knowledge, this was the longest observation period regarding the use of APC in treatment of ODP-M.

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Section: Introductionmentioning

confidence: 99%

Long-term outcomes of autologous platelet treatment for optic disc pit maculopathy

Gklavas

Athanasiou

Neubauer

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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Choroid Involvement Secondary to Optic Disc Pit Maculopathy: OCT Analysis and Evolution After Surgical Treatment

Carlà,

Boselli,

Giannuzzi

et al. 2025

American Journal of Ophthalmology

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Management of optic disc pit maculopathy: the European VitreoRetinal society optic pit study

Irós

Parolini²,

Özdek

et al. 2021

Acta Ophthalmologica

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Purpose: To evaluate a variety of techniques, and their anatomical and functional results, for the treatment of optic disc pit maculopathy (ODP-M). A secondary aim was to report on results of secondary procedures in cases of initial failure or recurrence. Methods: Multicentre retrospective study of 95 eyes with ODP-M, treated by 25 surgeons from 12 countries. Primary outcomes were anatomical resolution of subretinal fluid (SRF), intraretinal fluid (IRF) and visual acuity (VA) at 12 months. Results: Higher rates of SRF and IRF resorption were achieved in eyes treated with pars plana vitrectomy (PPV) compared to external laser with or without tamponade: 64/ 72 (88.9%) versus 8/14 (57.1%) for SRF (p = 0.003), and 50/59 (84.7%) versus 3/10 (30%) for IRF (p = 0.002). The addition of juxtapapillary laser or internal limiting membrane (ILM) peel during PPV did not improve SRF or IRF resolution. Pars plana vitrectomy (PPV) with tamponade and PPV with tamponade plus endolaser were associated with significant visual gain. In the former group, VA improved from a mean of logMAR 0.91 (20/162), to a mean of logMAR 0.52 (20/66) at 12 months; in the latter group, VA improved from a mean of logMAR 0.82 (20/132) to a mean of logMAR 0.47 (20/59) at 12 months. Retreatments were performed in 14 eyes (15.7%), only enhancing anatomical outcomes. Conclusion: Vitrectomy with tamponade had better final outcomes than external laser treatment with or without gas tamponade. Laser endophotocoagulation and ILM peel provided no additional benefit. A secondary treatment resulted in anatomical but not functional improvement.

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Makulaveränderungen bei Grubenpapille – „Optic disc pit maculopathy“ (ODP-M)

Cited by 5 publications

References 26 publications

Long-term outcomes of autologous platelet treatment for optic disc pit maculopathy

Long-term outcomes of autologous platelet treatment for optic disc pit maculopathy

Choroid Involvement Secondary to Optic Disc Pit Maculopathy: OCT Analysis and Evolution After Surgical Treatment

Management of optic disc pit maculopathy: the European VitreoRetinal society optic pit study

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