“…The analyses of the methylation status of MAL in normal cells and in a number of tumor specimens and tumor-derived cell lines indicate that the MAL CpG island is the subject of methylation, and that this epigenetic mechanism contributes to the downregulation of MAL gene expression in many cancers [ 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 , 214 , 215 ]. The use of different methods—the sequencing of bisulfite-treated DNA, methylation-specific PCR (MSP), quantitative MSP, pyrosequencing, etc.…”