Malabsorption of iron in children with iron deficiency

Gross, Steven J.; Stuart, Marie J.; Swender, Phillip T.; Oski, Frank A.

doi:10.1016/s0022-3476(76)81117-1

Cited by 49 publications

(24 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We in cline to think that geophagia might be the contributory factor in impaired absorption of iron and zinc. The results of the present study also confirm the findings of G ross et al [6] who recently demonstrated an inability to absorb oral iron in 6 patients.…”

Section: Discussionsupporting

confidence: 93%

Decreased Iron and Zinc Absorption in Turkish Children with Iron Deficiency and Geophagia

Arcasoy

Çavdar

Babacan³

1978

Acta Haematol

View full text Add to dashboard Cite

Oral iron and zinc tolerance tests were performed in 12 patients between 8 and 21 years of age, with iron deficiency anemia and geophagia. Decreased iron and zinc absorption were detected respectively in patients against the elevated absorption curves in control subjects. Iron and zinc malabsorption may be an additional feature of the syndrome characterized by geophagia, iron deficiency anemia, hepatosplenomegaly, hypogonadism and dwarfism observed in Turkey and Iran.

show abstract

Section: Discussionsupporting

confidence: 93%

Decreased Iron and Zinc Absorption in Turkish Children with Iron Deficiency and Geophagia

Arcasoy

Çavdar

Babacan³

1978

Acta Haematol

View full text Add to dashboard Cite

show abstract

“…We have recently studied 2 patients with severe iron deficiency anemia without any evidence of hemorrhage, but who showed complete achylia gastrica and malabsorption of iron; 1 of them showed no improvement when treated orally with an iron prepara tion, but when the iron administration was given parenterally, his recov ery was spectacular. It has also been thought that a deficiency of gastric secretion may be one cause of the iron deficiency anemia observed in children [15].…”

Section: Discussionmentioning

confidence: 99%

Inorganic Iron Absorption in Subjects with Iron Deficiency Anemia, Achylia gastrica and Alcoholic Cirrhosis Using a Whole-Body Counter

et al. 1978

View full text Add to dashboard Cite

A precise, although technically complicated method is described for the estimation of iron absorption. A steel chamber is used to measure the total radioactivity of the patients. A dose of ⁵⁹Fe is administered orally and the retention of radioactivity is measured on the 14th day, this amount being equivalent to the amount absorbed. In our male group, the mean absorption of inorganic iron was 22.5 ± 8%, and in females it was 43.3 ± 11%. In 10 patients with iron deficiency anemia, the mean was 92.2 ± 6%, in 10 with gastric achylia it was 4.6 ± 4%, and in 12 chronic alcoholics a value of 13.9 ± 7% was found.

show abstract

“…Defective iron absorption was demonstrated by a rise of 13 mol/L in serum iron compared with a minimal expected rise of 18 mol/L for children with comparable IDA. 13 Consequently, he was given a course of intravenous iron (iron sucrose 100 mg weekly during 3 consecutive weeks). Serum ferritin rose from 11 g/L to 109 g/L and hemoglobin rose from 68 g/L before the treatment to a maximum of 98 g/L.…”

Section: Methodsmentioning

confidence: 99%

Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency

Guillem

Lawson

Kannengiesser

et al. 2008

Blood

115

View full text Add to dashboard Cite

Genetic causes of hypochromic microcytic anemia include thalassemias and some rare inherited diseases such as DMT1 deficiency. Here, we show that iron deficiency anemia with poor intestinal absorption and defective iron utilization of IV iron is caused by inherited mutations in TMPRSS6, a liver-expressed gene that encodes a membrane-bound serine protease of previously unknown role that IntroductionHypochromic microcytic anemia is quite common in children with poor iron intake. 1 Genetic causes include thalassemias 2 and some rare inherited forms with defective absorption and use of iron. 3,4 Recently, several groups, 5,6,7 including ours, 7 have reported genetic defects of the iron transporter DMT1 in such patients. It is noteworthy that DMT1 mutations causing microcytic anemia have been associated with rather high serum iron and transferrin saturation as well as increased hepatic iron stores. 8 Here we report the case of a young patient with microcytic iron-refractory iron deficiency anemia (IRIDA) who is a compound heterozygote for 2 nonsense mutations in the transmembrane serine protease TMPRSS6. Mutations in this gene have been recently described in the Mask mouse, a mouse model of IRIDA, 9,10 and TMPRSS6 knock-out mice also display the same phenotype. 11 Our observations confirm a very recent communication reporting germ line mutations of TMPRSS6 in IRIDA patients 12 MethodsThe proband was born to nonconsanguinous English parents and was 18 months old when microcytic hypochromic anemia was first diagnosed. He presented with rotavirus gastroenteritis and he was incidentally found to have a hemoglobin concentration of 60 g/L, mean corpuscular volume of 47 fL, and serum iron below 5 mol/L. He is one of dizygotic twins and has one elder sister. In retrospect, he was thought to be mildly symptomatic of anemia as parents felt he was more lethargic than his twin sister. Both parents are normal and he is the only affected sibling (Table 1). Serum haptoglobin concentration was normal. Thereafter, serum iron was consistently low (Ͻ 5 mol/L), transferrin saturation was less than 5%, and serum ferritin was usually in the lower normal range. Three attempts were undertaken to correct the iron deficiency with 200 mg oral iron per day for either 6 months when he was 21 months old or for 3 months at the age of 3 years and once again at the age of 6 years. He failed to respond to oral iron, with no improvement in hemoglobin levels and serum iron remaining below 5 mol/L. At the age of 7 years, iron absorption was assessed by administration of oral ferrous iron at 3 mg/kg followed by measurement of serum iron at 3 hours. Defective iron absorption was demonstrated by a rise of 13 mol/L in serum iron compared with a minimal expected rise of 18 mol/L for children with comparable IDA. 13 Consequently, he was given a course of intravenous iron (iron sucrose 100 mg weekly during 3 consecutive weeks). Serum ferritin rose from 11 g/L to 109 g/L and hemoglobin rose from 68 g/L before the treatment to a maximum of 98 g/L. Microcytosis ...

show abstract

Malabsorption of iron in children with iron deficiency

Cited by 49 publications

References 13 publications

Decreased Iron and Zinc Absorption in Turkish Children with Iron Deficiency and Geophagia

Decreased Iron and Zinc Absorption in Turkish Children with Iron Deficiency and Geophagia

Inorganic Iron Absorption in Subjects with Iron Deficiency Anemia, Achylia gastrica and Alcoholic Cirrhosis Using a Whole-Body Counter

Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency

Contact Info

Product

Resources

About