Malabsorption syndrome in ascariasis

Tripathy, Kshetrabasi; Duque, Edgar; Bolaños, Óscar; Lotero, H; Mayoral, Luis Guillermo

doi:10.1093/ajcn/25.11.1276

Cited by 95 publications

(46 citation statements)

References 9 publications

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“…This is in contrast to the prevailing opinion that at least A. lumbricoides infection is an important cause of vitamin A deficiency, although this evidence seems vague: several studies have demonstrated impaired vitamin A absorption in children and adults (Mahalanabis et al, 1976;Sivakumar & Reddy, 1975;Tripathy et al, 1972) with A. lumbricoides infection. However, while some studies have shown that the vitamin A malabsorption is reversible upon treatment, they could not demonstrate a correlation between intensity of infection and degree of malabsorption (Mahalanabis et al, 1976;Sivakumar & Reddy, 1975).…”

Section: S Mansoni and Geohelminth Infectionsmentioning

confidence: 82%

“…The lack of effect of multi-helminth treatment on serum retinol was intriguing, especially in view of previous reports that S. mansoni (Friis et al, 1996(Friis et al, ,1997Mikhail & Mansour, 1982;Sturchler et al, 1983) and A. lumbricoides (Mahalanabis et al, 1976;Sivakumar & Reddy, 1975;Tripathy et al, 1972) infection impair serum retinol. However, through interaction analyses an effect of treatment was revealed in children found to be S. mansoni infected at baseline, but not in children found infected with any of the geohelminth infections.…”

Section: S Mansoni and Geohelminth Infectionsmentioning

confidence: 99%

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Effects on serum retinol of multi-micronutrient supplementation and multi-helminth chemotherapy: a randomised, controlled trial in Kenyan school children

et al. 2002

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Objective: To assess the effects of multi-micronutrient supplementation and multi-helminth chemotherapy on serum retinol concentration, using schools as a health delivery system. Study area and population: From 19 primary schools in Bondo District, western Kenya, 977 children between 9 and 18 y were included in the trial. The 644 (65.9%) children on whom baseline serum retinol was available were included in this study. Design: A randomised, placebo-controlled, double-blind, two-by-two factorial trial on the effects of multi-micronutrient supplementation and multi-helminth chemotherapy on serum retinol after 8 months. Intervention: Single treatment with albendazole (600 mg) and praziquantel (40 mg=kg of body weight) and daily multimicronutrient supplementation with tablet containing 1000 mg vitamin A. Results: Micronutrient supplementation (0.08 mmol=l, 95% CI 0.01, 0.14; P ¼ 0.025), but not treatment (0.03 mmol=l, 95% CI 7 0.04, 0.10; P ¼ 0.38), increased serum retinol. However, treatment did increase serum retinol in S. mansoni-infected (0.09, 95% CI 0.02, 0.16; P ¼ 0.009), but not in uninfected children ( 7 0.07, 95% CI 7 0.18, 0.03; P ¼ 0.18; interaction, P ¼ 0.01). Similarly, reduction in egg output of S. mansoni, but none of the geohelminth, was a predictor, corresponding to a 0.008 mmol=l (95% CI 0.00002, 0.02; P ¼ 0.049) increase in serum retinol per 100 epg reduction. Interestingly, interactions were found between age and sex (P ¼ 0.046), and malaria parasitaemia and sickle cell phenotype (P ¼ 0.04). Conclusion: Multi-micronutrient supplementation and reduction in S. mansoni egg output increased serum retinol, irrespective of initial serum retinol.

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Section: S Mansoni and Geohelminth Infectionsmentioning

confidence: 82%

Section: S Mansoni and Geohelminth Infectionsmentioning

confidence: 99%

Effects on serum retinol of multi-micronutrient supplementation and multi-helminth chemotherapy: a randomised, controlled trial in Kenyan school children

et al. 2002

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“…A. lumbricoides has profound effects on infected children that lead to retarded growth, deficiencies of nutrients, damage of the small intestine mucosa, and lethal hypersensitivity responses (19,29,44). The developmental cycle of A. lumbricoides involves two distinct patterns: a tissue-migratory phase involving the liver with infective third-stage larvae (L3) and the lungs with L3 and fourth-stage larvae (L4), and a noninvasive phase with adult worms that finally reside in the small intestine.…”

mentioning

confidence: 99%

Pyrophosphatase of the RoundwormAscaris suumPlays an Essential Role in the Worm's Molting and Development

et al. 2005

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“…Childhood infections with ascariasis are associated with growth stunting (24), deficiencies of macro-and micronutrients (10,24), and small intestinal mucosal damage and malabsorption (24,33). The presence of A. lumbricoides parasites in the small bowel may affect also the immune response to oral vaccines and explain the relatively poor immunogenicity of several live oral vaccines in certain populations of Asia, Africa, and Latin America compared with that seen in volunteers from industrialized countries.…”

mentioning

confidence: 99%

Human Infection withAscaris lumbricoidesIs Associated with Suppression of the Interleukin-2 Response to Recombinant Cholera Toxin B Subunit following Vaccination with the Live Oral Cholera Vaccine CVD 103-HgR

et al. 2001

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To investigate the potential immunomodulatory effects of concurrent ascariasis on the cytokine response to a live oral vaccine, we measured cytokine responses to cholera toxin B subunit (CT-B) following vaccination with the live oral cholera vaccine CVD 103-HgR in Ascaris lumbricoides-infected subjects randomized in a double-blind study to receive two doses of either albendazole or placebo prior to vaccination and in a group of healthy U.S. controls. Postvaccination cytokine responses to CT-B were characterized by transient increases in the production of interleukin-2 (IL-2; P ‫؍‬ 0.02) and gamma interferon (IFN-␥; P ‫؍‬ 0.001) in the three study groups combined; however, postvaccination increases in IFN-␥ were significant only in the albendazole-treated A. lumbricoides infection group (P ‫؍‬ 0.008). Postvaccination levels of IL-2 were significantly greater in the albendazole-treated group compared with the placebo group (P ‫؍‬ 0.03). No changes in levels of Th1 and Th2 cytokines in response to control ascaris antigens were observed over the same period. These findings indicate that vaccination with CVD 103-HgR is associated with a Th1 cytokine response (IL-2 and IFN-␥) to CT-B, that infection with A. lumbricoides diminishes the magnitude of this response, and that albendazole treatment prior to vaccination was able to partially reverse the deficit in IL-2. The potential modulation of the immune response to oral vaccines by geohelminth parasites has important implications for the design of vaccination campaigns in geohelminth-endemic areas.

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Malabsorption syndrome in ascariasis

Cited by 95 publications

References 9 publications

Effects on serum retinol of multi-micronutrient supplementation and multi-helminth chemotherapy: a randomised, controlled trial in Kenyan school children

Effects on serum retinol of multi-micronutrient supplementation and multi-helminth chemotherapy: a randomised, controlled trial in Kenyan school children

Pyrophosphatase of the RoundwormAscaris suumPlays an Essential Role in the Worm's Molting and Development

Human Infection withAscaris lumbricoidesIs Associated with Suppression of the Interleukin-2 Response to Recombinant Cholera Toxin B Subunit following Vaccination with the Live Oral Cholera Vaccine CVD 103-HgR

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