Malabsorption syndrome with cow's milk intolerance. Clinical findings and course in 54 cases.

Kuitunen, P; Visakorpi, J. K.; Savilahti, Erkki; Pelkonen, P.

doi:10.1136/adc.50.5.351

Cited by 284 publications

(148 citation statements)

References 14 publications

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“…This lesion disappears when the offending food is removed and reappears when the food is returned to the diet (36)(37)(38)(40)(41)(42), and it is fully described in these and other reports. Essentially, the villi of the intestinal mucosa become flattened and the lamina propria is infiltrated by lymphoid cells shown to be producing specific antibodies of IgA, IgG, IgM and sometimes IgE classes of immunoglobulins.…”

Section: Acute Gastroenteropathysupporting

confidence: 50%

A Modern Clinical Approach to Food Hypersensitivity

May

Block

1978

Allergy

107

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Section: Acute Gastroenteropathysupporting

confidence: 50%

A Modern Clinical Approach to Food Hypersensitivity

May

Block

1978

Allergy

107

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“…In one study, however, passive cutaneous anaphylaxis in guinea pigs was the only test found to discriminate between allergic and nonallergic children (96), and in another study no significant difference was found between children with CMA and controls either by passive haemagglutination technique for detection of antibodies to CM (16). Precipitating antibodies to CM are frequently, but not invariably present in children with CMA (6,52,69), whereas in patients in whom skin symptoms predominate the level is mostly normal (86). When CM is eliminated, IgA falls, and during a positive challenge test it is often seen to rise (52,98), such a rise being less frequent after short challenges and in patients with AD (86).…”

Section: Antibodies To C M In Diseasementioning

confidence: 99%

“…Children with CMA frequently have eosinophilia during CM feeding, this sign being present in one third to half of the patients (6,69). No increase in the numbers of eosinophils has been seen during challenges (79,90).…”

Section: Eosinophils In C M Amentioning

confidence: 99%

Cow's Milk Allergy

Savilahti

1981

Allergy

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By the end of the last century prevention of waterborne infections by chlorination of water supplies, pasteurization of cow's milk (CM) and production of suitable, easily cleaned bottles and nipples for infants had made artificial infant feeding a relatively safe procedure. But in the early years of the present century unexplained difficulties were reported in infants fed with cow's milk; some of them had continuous diarrhoea and failed to thrive (103). It was speculated that such infants had difficulty in digesting foreign proteins, although they could readily assimilate those in breast milk. In the following years cases of anaphylactic shock caused by CM were described, one of them with a fatal outcome (29). Animal studies showed that one species produced precipitins to proteins of milk from another species, and this type of reaction to the foreign structure of CM proteins was presumed to account for the symptoms seen in infants (29). In 1906, precipitins to CM were found in blood from a marasmic infant fed with CM (80). A year later reports appeared describing successful desensitization: injections of small quantities of cow serum cured and prevented hypersensitivity to oral CM and its symptoms (102). This was not a solution to the problem, however, as treatment with serum caused severe reactions (95). The mechanism and components of C M causing these reactions were debated. Wernstedt suggested that the symptoms were due to altered reactivity to CM because of earlier contact with it, and proposed that it should be called allergy (119). Subsequently, the intestinal symptoms were shown to be caused by the whey fraction of CM (42). They were noted to vary in severity and disappeared with increasing age. A decade later (1921) urticaria was described as a symptom of CM hypersensitivity (104). By the 1930's and 40's however, CMA was considered a rare disease ( I 12), but the decrease in breast feeding in most developed countries has made cow's milk allergy (CMA) an important cause of infant morbidity and one of the best known and most frequently encountered problems in current infant feeding practices. DEFINITIONThe majority of infants can be reared on CM formulas without untoward effects. However, sensitive immunochemical methods show that they do react to the foreign proteins in CM. When the immunologic reactions to CM are associated with clinical symptoms, the child can be said to be allergic to CM (89). Obviously, the simplest and the most convincing way to verify cow's milk allergy (CMA) would be to demonstrate this either abnormally strong or qualitatively altered immune reaction to C M proteins. As yet, however, this cannot be done by any single test or combination of tests. Therefore the diagnosis of CMA has to be based on the clinical response to CM. In most cases it is enough to observe a favourable response to elimination of CM, reappearance of symptoms during one challenge test and their -disappearance on renewed elimination. When symptoms are severe it is unethical to perform more than one challenge.Ot...

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“…The prevalence of a concomitant intolerance to soy in the allergy to cow milk is between 0% and 63% with high levels in the enterocolitis/enteropathy syndromes not associated with IgE (Van Sickle et al, 1985;Bock, Atkins, 1990;Ragno et al, 1993;Burks et al, 1994;Harikul et al, 1995). However, the true prevalence of allergy to soy proteins in documented allergies to proteins in cow milk is not yet well established (Kuitunen et al, 1975;Jakobsson, Lindberg, 1979;Zeiger et al, 1999;Ahn et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Immunogenicity and allergenicity of 2S, 7S and 11S soy protein fractions

Bittencourt

Soares²,

Pires³

et al. 2007

Rev. Bras. Cienc. Farm.

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It is known that in a part of the population, mainly among children, some are hypersensitive to soybean protein, although it is not yet completely elucidated which protein fraction is more immunogenic/ allergenic. The objective of the study was to compare the immunogenicity and allergenicity of the soy protein fractions. The 2S (conglycinin), 7S (β conglycinin) and 11S (glycinin) fractions were isolated from soy protein by affinity chromatography. These purified soy protein fractions were used as antigens for immunizing BALB/c mice to evaluate their immunogenicity by following the appearance of specific IgM and IgG antibodies in blood serum by ELISA. The allergenicity of these soy protein fractions was evaluated by the following approaches: i) the production of IgE antibodies against 2S, 7S and 11S soy protein fractions by BALBc mice in the anaphylactic cutaneous passive test (PCA), and ii) the production of IgG1 specific antibodies against the 7S fraction in BALB/c mice. The 7S and 11S fractions induced the formation of IgM and IgG antibodies. The PCA test showed that only the 7S fraction was allergenic leading to the production of IgE antibodies. Another evidence that reinforces the allergenicity of the 7S soy protein fraction is the presence of IgG1 specific antibodies reactive to this protein fraction in immunized mice. Our study shows that the 7S soy protein fraction is important to elicit allergic reactions in mice and may contribute to elucidate the allergenicity of soy-derived products. INTRODUCTIONAllergic reactions to foods result from heightened immunologic responses to glycoprotein components present in the foods and constitute a frequent health complaint (Metcalfe, 1991;Shah, Walker, 2002). Children and adults who develop such reactions are said to have a food hypersensitivity or food allergy that are terms proposed to define a reaction to food exposure causing objectively reproducible symptoms or signs at a dose A. L. Bittencourt, M. F. M. Soares, R. R. Pires, C. S. Honmoto, M. K. Tanaka, C. M. A. Jacob, D. S. P. Abdalla 598 tolerated by normal subjects (Crespo et al., 2004). The prevalence of food allergy in children appears to be increasing for reasons that are still poorly understood. It has been estimated that approximately 6% of young children and about 2% of the general population have food allergy, with the majority experiencing gastrointestinal symptoms (Sampson, 2003).A number of factors can affect the development of food allergy. One is the amount of a particular food that is ingested, which is influenced by diet and culture of a country. This can have a significant effect on the prevalence of a specific food allergy in that region. Examples of this are codfish allergy in Norway, rice and soy allergy in Japan, and peanut allergy in the U.S. Other factors involved in food allergies are the gut permeability, that has been considered to be a major factor in food allergy sensitization, and the food processing that can substantially modify food allergen content. Most food allergens are stable ...

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Malabsorption syndrome with cow's milk intolerance. Clinical findings and course in 54 cases.

Cited by 284 publications

References 14 publications

A Modern Clinical Approach to Food Hypersensitivity

A Modern Clinical Approach to Food Hypersensitivity

Cow's Milk Allergy

Immunogenicity and allergenicity of 2S, 7S and 11S soy protein fractions

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