Malacoplakia, a rare inflammatory lesion, afflicts the genitourinary system in most cases. A 22-year-old women had a recurrence of urethral malacoplakia that had been excised 5 years earlier. The recurrence was accompanied by staphylococcal infection in the urinary tract. The pathological specimens in both instances had the features typical of malacoplakia with von Hansemann cells and Michaelis-Gutmann bodies.