Maladaptive personality traits in patients with epilepsy and psychogenic non-epileptic seizures

Kustov, G.; Zhuravlev, D.; Zinchuk, M.; Popova, S.; Tikhonova, O.; Yakovlev, A.; Rider, F.; Guekht, A.

doi:10.1016/j.seizure.2024.02.005

Seizure: European Journal of Epilepsy

2024

DOI: 10.1016/j.seizure.2024.02.005

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Maladaptive personality traits in patients with epilepsy and psychogenic non-epileptic seizures

G. Kustov,

D. Zhuravlev,

M. Zinchuk

et al.

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Cited by 3 publications

References 57 publications

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Prevalence and correlates of alexithymia in drug-resistant epilepsies

Paradas,

Pradier,

Decilap

et al. 2025

Epilepsy & Behavior

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Prevalence and correlates of alexithymia in drug-resistant epilepsies

Paradas,

Pradier,

Decilap

et al. 2025

Epilepsy & Behavior

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Psychiatric Comorbidities in Functional Neurological Disorders and Psychogenic Non-Epileptic Seizures: A Systematic Review and Policy Recommendations for Improving Assessment and Treatment

Lazzari,

Nikolou-Walker,

Liu

et al. 2024

NDT

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Background Psychogenic Non-Epileptic Seizures (PNES) and Functional Neurological Disorders (FND) are progressively attracting the attention of healthcare professionals both in the medical or surgical specialties and in psychiatric ones. Methods Due to FND and PNES complex presentation, often comorbid with other neurological, medical, and psychiatric conditions, starting from our experience with patients presenting with both conditions, we conducted a systematic review of articles that address the comorbidity of PNES and FND with other psychiatric conditions. Results Our review supports the point that PNES and FND are not autonomous conditions but develop on the grounds of other psychiatric comorbidities including autism, borderline personality disorder (BPD), post-traumatic stress disorder (PTSD), and alexithymia. Persons with PNES and FND have often a history of child abuse, neglect, and trauma, and these conditions can also trigger the two conditions if appearing later in life. We also propose policies to endorse the comorbidity theory and improve assessment and treatment. Conclusion The scrutinized studies confirm that PNES and FND might be comorbid or represent manifestations of what we hypothesize as an integrated biopsychosocial model where early trauma, abuse, and neglect lead to a progressive neuro sensitivity that can present in the same person, usually young female patients, as a combination of dysthymia, alexithymia, autism, PTSD, BPD, FND, and PNES.

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Personality disorders in people with epilepsy: a review

Viola,

Bisulli,

Cornaggia

et al. 2024

Front. Psychiatry

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Epileptologists and psychiatrists have long observed a correlation between epilepsy and personality disorders (PDs) in their clinical practice. We conducted a comprehensive PubMed search looking for evidence on PDs in people with epilepsy (PwE). Out of over 600 results obtained without applying any time restriction, we selected only relevant studies (both analytical and descriptive) limited to English, Italian, French and Spanish languages, with a specific focus on PDs, rather than traits or symptoms, thus narrowing our search down to 23 eligible studies. PDs have been investigated in focal epilepsy (predominantly temporal lobe epilepsy - TLE), juvenile myoclonic epilepsy (JME) and psychogenic non-epileptic seizures (PNES), with heterogeneous methodology. Prevalence rates of PDs in focal epilepsy ranged from 18 to 42% in surgical candidates or post-surgical individuals, with Cluster C personality disorders or related traits and symptoms being most common. In JME, prevalence rates ranged from 8 to 23%, with no strong correlation with any specific PDs subtype. In PNES, prevalence rates ranged from 30 to 60%, with a notable association with Cluster B personality disorders, particularly borderline personality disorder. The presence of a PD in PwE, irrespective of subtype, complicates treatment management. However, substantial gaps of knowledge exist concerning the neurobiological substrate, effects of antiseizure medications and epilepsy surgery on concomitant PDs, all of which are indeed potential paths for future research.

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Maladaptive personality traits in patients with epilepsy and psychogenic non-epileptic seizures

Cited by 3 publications

References 57 publications

Prevalence and correlates of alexithymia in drug-resistant epilepsies

Prevalence and correlates of alexithymia in drug-resistant epilepsies

Psychiatric Comorbidities in Functional Neurological Disorders and Psychogenic Non-Epileptic Seizures: A Systematic Review and Policy Recommendations for Improving Assessment and Treatment

Personality disorders in people with epilepsy: a review

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