Maladie dermatophytique : à propos d’un cas

Souissi, A.; Karray, M.; Chelly, Inès; Zehani, Alia; Hafsi, Wissem; Euch, D. El; Kchir, N.; Mokni, M.

doi:10.1016/j.revmed.2017.03.325

Cited by 1 publication

(5 citation statements)

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“…It is particularly prevalent in North Africa, with Algeria reporting the highest number of cases. 27,29 This condition primarily affects adults aged 29-41 and is highly prevalent in individuals with consanguineous relationships. 29 Concerning the distribution of CARD9 mutations across different geographic regions, a similar pattern is evident.…”

Section: Discussionmentioning

confidence: 99%

“…27,29 This condition primarily affects adults aged 29-41 and is highly prevalent in individuals with consanguineous relationships. 29 Concerning the distribution of CARD9 mutations across different geographic regions, a similar pattern is evident. 23 The main mutations were identified as HMZ p.Q289X (c.865C > T) and HMZ p.R101C (c.C301T), constituting 75% and 10% of cases, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…CARD9 AR deficiencies were identified in 13 Algerian, 22 Tunisian 22 and Moroccan 29 families. Our study reported a consanguineous family origin in 38.0% of cases.…”

Section: Discussionmentioning

confidence: 99%

“…Dermatophytic disease is a chronic mycosis that can affect superficial and deep tissues and is an infrequent deep infection. It is particularly prevalent in North Africa, with Algeria reporting the highest number of cases 27,29 . This condition primarily affects adults aged 29–41 and is highly prevalent in individuals with consanguineous relationships 29 …”

Section: Discussionmentioning

confidence: 99%

“…It is particularly prevalent in North Africa, with Algeria reporting the highest number of cases 27,29 . This condition primarily affects adults aged 29–41 and is highly prevalent in individuals with consanguineous relationships 29 …”

Section: Discussionmentioning

confidence: 99%

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CARD9 mutations in patients with fungal infections: An update from the last 5 years

Dantas,

Cintra,

Lucini

et al. 2024

Mycoses

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BackgroundAutosomal recessive deficiency in the caspase recruitment domain‐containing protein 9 (CARD9) is a congenital immunological condition that leads to susceptibility to mucocutaneous and invasive fungal infections. There is growing incidence of fungal infections in patients with CARD9 deficiency, a phenomenon that is increasingly recognised.ObjectivesThis study aimed to assess the frequency, geographic distribution and nature of mutations in patients with CARD9 deficiency, based on published papers in the literature until March 2023.MethodsWe swiftly conducted a study to pinpoint every documented instance of fungal infections arising from CARD9 deficiency. We selected case reports from the databases of PubMed, Embase, Scopus and Google Scholar spanning the period from October 2009 to March 2023.ResultsWe analysed 90 cases of fungal infections and identified 32 mutations in the CARD9 gene. Notably, the homozygous (HMZ) p.Q295X (c.883C > T) mutation was associated with an increased risk of candidiasis. In contrast, the HMZ p.Q289X (c.865C > T) mutation is linked to a higher risk of dermatophytosis. We observed differences in the geographical distribution of these mutations. The primary mutations found in African patients differ from those in Asian patients. Specifically, Asian patients exhibit a broader spectrum of CARD9 mutations than African patients.ConclusionsThe diversity of mutations observed in the 90 cases revealed 32 distinct variations, emphasising the unique genetic alterations in the CARD9 gene associated with specific geographical areas and the corresponding prevalence of fungal infections.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…CARD9 AR deficiencies were identified in 13 Algerian, 22 Tunisian 22 and Moroccan 29 families. Our study reported a consanguineous family origin in 38.0% of cases.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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