Malakoplakia of the gastrointestinal tract

Abstract

Summary The clinical and pathological features of 3 cases of colonic malakoplakia are documented thereby bringing to 34 the total of recorded cases of malakoplakia involving the gastrointestinal tract. This is therefore the most common site of involvement outside the urogenital tract. A comprehensive review of the world literature on gastrointestinal malakoplakia has been made and the characteristic features of the condition have been delineated. There was a bimodal age incidence with a small cluster of cases occurring in childhood and associated with significant additional systemic disease. In the adult cases the average age was 57 years with a slight excess of males. The most commonly involved part of the gastrointestinal tract was the colon and colonic carcinoma was the most common associated disease.

Renal malakolpkia followed by chronic myelogenous leukaemia: treatment challenges case report and literature review

“…The association between malakoplakia and colon cancer is well documented in the literature. An early report found an association between the two conditions in more than 30% of cases,8 while recent findings suggest that malakoplakia occurs as an incidental finding confined to the area adjacent to the carcinoma 9…”

CT of colonic malakoplakia in a patient with AIDS.

“…The most common signs and symptoms include diarrhea, abdominal pain, bleeding, and fever [3]. Localized dis easecan usually be cured by surgical resec tion.…”

“…Malakoplakia of the colon is a rare disease, with fewer than 40 casesbeing reportedto our knowledge [2,3]. Colonic malakoplakia can occur as either a primary finding or an associ ated finding in patients with colonic carcinoma [4,5].…”

Pulmonary malakoplakia associated with immunodeficiency by HTLV-1 and HIV

“…Some of these cells may contain amorphous, rounded cytoplasmic inclusions, with centers of concentric membranes, which are bacteria fragments with target or owl eye aspect, they are basophilic and PAS (periodic acid-Schiff) positives. Because they contain ferric salt and phosphate salt deposits, they are positive, respectively, to Pearls and Von Kossa, known as MG bodies (1,3,8,10,11) . It is also known, by the experience of most authors, that MG bodies are easily recognized by Papanicolaou, Diff-Quik, and hematoxylin-eosin staining (2) .…”

“…Clinically, it varies from silent nodules to different manifestations, simulating bronchogenic carcinoma or tuberculosis. Malakoplakia should always be considered as a differential diagnosis, in order to prevent misinterpretation of large nodules with fast growth, such as tumors, avoiding unnecessary and radical surgeries (4,8) . Our cases report presented fever, cough, hemoptysis, weight lost, and chest pain, suggestive of neoplasia, tuberculosis, and e pneumonia.…”