Malakoplakia of the nasopharynx associated with carcinoma

McCormick, M; Timme, A. H.

doi:10.1017/s0022215100093063

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…As malakoplakia can mimic a neoplastic process, it may also be associated with other chronic inflammatory conditions, such as Whipple disease, Ché diak-Steinbrinck-Higashi syndrome, tuberculosis, sarcoidosis, and immunodeficiency. 6 Whereas the association of malakoplakia and carcinoma has been reported, 7 to our knowledge there are no cases in which malignant transformation of malakoplakia has occurred.…”

Section: Resultsmentioning

confidence: 94%

Malakoplakia of the Neck

Schmerber

Lantuéjoul²,

Lavieille³

et al. 2003

Arch Otolaryngol Head Neck Surg

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Malakoplakia that presents in the head and neck is very rare. We describe a 76-year-old man who presented with an inflammatory mass in the lateral aspect of the neck that clinically mimicked a tumoral expansion and was consistent with a cervical malakoplakia. To our knowledge, this is the second case reported with manifestations of this chronic inflammatory disease localized in the neck. Malakoplakia is a rare granulomatous disease that most frequently involves the genitourinary tract and occurs in an immunodeficient host. The symptoms are nonspecific and the diagnosis is based on the histologic findings. In the present case, the biopsy specimen of the cervical mass revealed a collection of numerous von Hansemann cells containing Michaelis-Gutmann bodies, which are pathognomonic of malakoplakia. Bacteriologic analysis identified Escherichia coli. The evolution was favorable after surgical excision and prolonged antibiotic therapy with fluoroquinolones.

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Section: Resultsmentioning

confidence: 94%

Malakoplakia of the Neck

Schmerber

Lantuéjoul²,

Lavieille³

et al. 2003

Arch Otolaryngol Head Neck Surg

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“…1985), larynx (Gabrielidese/a/., 1981)andmaxillary antrum (Nistale/al., 1985)have been reported. Only one case is previously described in the soft tissues of the neck, in which malakoplakia was associated with an underlying carcinoma of the nasopharynx (McCormick and Timme, 1982). The case described here presented clinically as a chronic inflammatory mass in the neck unassociated with other pathology mimicking actinomycosis.…”

Section: Introductionmentioning

confidence: 80%

Prediagnostic malakoplakia presenting as a chronic inflammatory mass in the soft tissues of the neck

et al. 1992

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Malakoplakia presenting in the head and neck is very rare. We present a case of an inflammatory mass in the neck, clinically mimicking actinomycosis in a 67-year-old man. Repeated culture of E. coli and histological and electron microscopic examination of biopsy material showed an infiltration of granular macrophages and intracellular gram negative bacilli, but no classical Michaelis-Gutmann bodies. The clinical and pathological findings and criteria for the diagnosis of malakoplakia are discussed.

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“…Though a facial palsy was present with the lesion encompassing the facial nerve in the temporal bone, the nerve was demonstrably intact. Surgical exploration was considered necessary for debridement, given the large size of the lesion and to permit detailed histopathological examination of the excised specimen, as coexistence of malakoplakia with carcinoma has been described (McCormick and Timme, 1982).…”

Section: Discussionmentioning

confidence: 99%

“…In the otolaryngological literature malakoplakic lesions have been described in the palatine tonsils, (Kalfayan and Seager, 1982), middle ear (Azadeh and Ardehali, 1983). maxillary sinus (Nistal et al 1985), nasopharynx (McCormick and Timme, 1982), base of tongue (Love et al, 1985), larynx (Gabrielides et al, 1981) and parotid gland (Dale and Robinson, 1988).…”

Section: Introductionmentioning

confidence: 99%