Malaria chemoprophylaxis in sickle cell disease

Abstract

Cochrane Database of Systematic Reviews Malaria chemoprophylaxis in sickle cell disease (Review) Oniyangi O, Omari AAA Oniyangi O, Omari AAA. Malaria chemoprophylaxis in sickle cell disease.

Sickle cell anemia in sub-Saharan Africa: advancing the clinical paradigm through partnerships and research

“…A multinational clinical trial comparing available treatment strategies would help establish evidence-based guidelines and reduce the morbidity and mortality of severe malarial infection. 39 …”

Pneumococcal infections and sickle cell disease in Africa: does absence of evidence imply evidence of absence?

“…Acute malaria infection is the single most common cause of hospitalisation in patients with SCD in Nigeria19 and the precipitating cause of acute crisis in 133 of 848 consecutive hospital admissions in Ghana 20. Increased morbidity and mortality have been reported in subjects who are not on malaria chemoprophylaxis 20 21 22 23 24…”

Effects of Age and Sex on Sickle Cell Disease Avascular Necrosis

“…In spite of the impressive improvements in the survival of patients with SCD, scientific advances in chronic bone diseases are still lagging [12,13]. AVN, which refers to bone destruction due to subchondral oxygen deficiency, remains Journal of Hematology and Blood Disorders Volume 2 | Issue 1 the leading cause of crippling disability and the most common manifestation in patients with SCD [14,15]. Approximately 50% of the individuals with SCD are likely to develop some form of bone fragility syndrome by the age of 35 years [3].…”