Malaria congénita por Plasmodium falciparum

Calderon, Jose Gabriel Del Castillo; Silva, Angie Milena Cardenas

doi:10.32641/rchped.v91i5.1283

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…These antibodies can provide some protection against the infection, but they may not be enough to prevent the development of signs in all cases. [5][6][7][8][9] In our case, the neonate presented to the health center within a day of onset of the signs, and the diagnosis was made on arrival. The referral to a better facility and initiation of treatment were completed on time.…”

Section: Dovepressmentioning

confidence: 99%

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Congenital Malaria in a 20-Day-Old Neonate: A Case Report and Literature Review

Regasa,

Shibiru,

Tilahun

et al. 2024

RRN

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Background: Congenital malaria is a relatively rare condition where the Plasmodium parasite is transmitted from the mother to the fetus during pregnancy. It is associated with a high fatality rate if it is not promptly diagnosed and treated. Case Summary: We report an unusual case of a 20-day-old male baby with Plasmodium vivax malaria from Western Ethiopia, suspected primarily on the basis of positive maternal history that mother had attacks of malaria in the 3 rd , 5th, and 8 th months of gestation and was cured with artemether-lumefantrine therapy. Infant presented with vomiting and a high-grade fever. The blood film of the baby showed trophozoites stage of Plasmodium vivax with a parasite density of +3. The neonate had severe thrombocytopenia (49,000/micro liter) and Splenomegaly (spleen was palpable 2cm along its line of growth). The patient was admitted to the hospital and treated with artesunate for five days and discharged on the sixth day of admission in stable condition. Conclusion: Sick neonates born to mothers in malaria-endemic areas or with a history of malaria attack(s) in the index pregnancy should be promptly investigated for malaria.

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Section: Dovepressmentioning

confidence: 99%

“…In general, early diagnosis of congenital malaria involves screening pregnant women for malaria infection, testing newborns for congenital malaria, monitoring for symptoms, and promptly treating any positive cases. [3][4][5] Here we present a case of a neonate with congenital malaria.…”

Section: Introductionmentioning

confidence: 99%

Congenital Malaria in a 20-Day-Old Neonate: A Case Report and Literature Review

Regasa,

Shibiru,

Tilahun

et al. 2024

RRN

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Prospective study of malaria in pregnancy, placental and congenital malaria in Northwest Colombia

Cardona-Arias,

Carmona-Fonseca

2024

Malar J

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Background Pregnancy Associated Malaria (PAM) include malaria in pregnancy (MiP), placental malaria (PM), and congenital malaria (CM). The evidence available in Colombia on PAM focuses on one of the presentations (MiP, PM or CM), and no study longitudinally analyses the infection from the pregnant woman, passing through the placenta, until culminating in the newborn. This study determined the frequency of MiP, PM, and CM caused by Plasmodium vivax, Plasmodium falciparum, or mixed infections, according to Thick Blood Smear (TBS) and quantitative Polymerase Chain Reaction (qPCR). Identifying associated factors of PAM and clinical-epidemiological outcomes in northwestern Colombia. Methods Prospective study of 431 pregnant women, their placenta, and newborns registered in the data bank of the research Group “Salud y Comunidad César Uribe Piedrahíta” which collected information between 2014 and 2020 in endemic municipalities of the departments of Córdoba and Antioquia. The frequency of infection was determined with 95% confidence intervals. Comparisons were made with the Chi-square test, Student t-test, prevalence ratios, and control for confounding variables by log-binomial regression. Results The frequency of MiP was 22.3% (4.6% using TBS), PM 24.8% (1.4% using TBS), and CM 11.8% (0% using TBS). Using TBS predominated P. vivax. Using qPCR the proportions of P. vivax and P. falciparum were similar for MiP and PM, but P. falciparum predominated in CM. The frequency was higher in nulliparous, and women with previous malaria. The main clinical effects of PAM were anaemia, low birth weight, and abnormal APGAR score. Conclusions The magnitude of infections was not detected with TBS because most cases were submicroscopic (TBS-negative, qPCR-positive). This confirmed the importance of improving the molecular detection of cases. PAM continue being underestimated in the country due to that in Colombia the control programme is based on TBS, despite its outcomes on maternal, and congenital health.

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Congenital malaria: Frequency and epidemiology in Colombia, 2009-2020

Cardona‐Arias

Carmona‐Fonseca

2022

PLoS ONE

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Congenital Malaria (CM) is an underestimated and under-researched problem in Colombia, despite its severe clinical, epidemiological, economic, and public health consequences. The objective was to determine the general frequency of CM, the specific frequency of CM by diagnostic test and plasmodial species, and identify its associated factors. A retrospective study was carried out using the records of 567 newborns. qPCR and Thick Blood Smear (TBS) were performed. The frequency of infection was determined with a 95% confidence interval. Associated factors were identified by non-parametric tests and odds ratios; the confusion was controlled with a logistic regression model. All cases corresponded to submicroscopic CM (negative with TBS and positive with PCR), and the frequency was 12.2% (95%CI = 9.4–14.9). The detection was statistically higher in the umbilical cord with 16,2% (95%CI = 12.4–19.9) versus peripheral blood of the newborn with 2.2% (95%CI = 0.7–4.9). CM was statistically higher in newborn whose mothers had malaria in the last year, gestational and placental malaria. The median birth weight in newborn infected with CM was lower compared to the one of healthy neonates. Because the control program in Colombia is based on TBS, it must be improved with the inclusion of other tests that allow the detection of submicroscopic CM. In addition, the program has other limitations such as do not have specific actions for pregnant women and have a passive surveillance system. These difficulties do not allow to show the magnitude of CM, its consequences on neonatal and infant health, constituting a serious problem of health injustice.

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Malaria congénita por Plasmodium falciparum

Cited by 3 publications

References 8 publications

Congenital Malaria in a 20-Day-Old Neonate: A Case Report and Literature Review

Congenital Malaria in a 20-Day-Old Neonate: A Case Report and Literature Review

Prospective study of malaria in pregnancy, placental and congenital malaria in Northwest Colombia

Congenital malaria: Frequency and epidemiology in Colombia, 2009-2020

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