Malaria in Pregnant Woman Masquerading as HELLP Syndrome

Ducarme, Guillaume; Thuillier, Claire; Wernet, Anne; Bellier, Claire; Luton, Dominique

doi:10.1055/s-0029-1234035

Cited by 9 publications

(5 citation statements)

References 8 publications

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“…Acute fatty liver of pregnancy (AFLP) and hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome) are associated with significant maternal and fetal morbidity and mortality (43,44). In previous studies, pregnant women infected with P. falciparum were shown to develop hepatitis (45) or HELLP-like syndrome (46)(47)(48). The patients proceeded to spontaneous abortion, stillbirth, and premature delivery.…”

Section: Discussionmentioning

confidence: 99%

Development of Severe Pathology in Immunized Pregnant Mice Challenged with Lethal Malaria Parasites

et al. 2013

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b Pregnant women are highly susceptible to malaria infection because of their low immunity and are at increased risk of maternal illness or death, in addition to spontaneous abortion, stillbirth, premature delivery, and low birth weight. However, the detailed pathogenesis of maternal malaria remains unclear. In this study, we evaluated a mouse model that shows similar severe pathological features of pregnant women during Plasmodium falciparum infection and investigated the pathogenesis of maternal malaria. Pregnant mice immunized by infection with an attenuated parasite, Plasmodium berghei XAT, were more susceptible to virulent P. berghei NK65 challenge/infection than were nonpregnant mice and showed high levels of parasitemia and a poor pregnancy outcome associated with placental pathology, such as accumulation of parasitized red blood cells, in the late phase of pregnancy. Notably, the pregnant immune mice challenged/infected with P. berghei NK65 developed liver injury associated with microvesicular fatty infiltration in late pregnancy. The pathological features were similar to acute fatty liver of pregnancy. Higher levels of gamma interferon and nitric oxide (NO) were found in plasma from pregnant immune mice infected with P. berghei NK65 than in plasma from nonpregnant mice. These findings suggest that development of liver injury and placental pathology in pregnant immune mice challenged/infected with P. berghei NK65 is accompanied by enhanced production of proinflammatory cytokines. Malaria is the most devastating parasitic disease of humans in tropical and subtropical regions, resulting in an estimated 0.6 to 1 million deaths per year (1). The populations at greatest risk of developing severe pathology are children under the age of 5 years and pregnant women in areas where Plasmodium falciparum is endemic (2-4). Every year, approximately 50 million women living in areas where malaria is endemic become pregnant. An estimated 10,000 of these women and 200,000 of their fetuses or infants die annually as a result of malaria during pregnancy (1, 2). Malaria during pregnancy is a major public health problem in areas of endemicity, especially in Africa.People living in regions where malaria is endemic acquire protective immunity against malaria parasites and often show asymptomatic infection. However, women are highly susceptible to malaria infection because of their low immunity during pregnancy and are at increased risk of maternal illness or death (5, 6). Malaria during pregnancy, in addition to maternal illness or death, is implicated in the occurrence of spontaneous abortion, stillbirth, premature delivery, and low birth weight (6). Recently, it has been demonstrated that pregnant mice infected with lethal Plasmodium berghei parasites show a feature similar to placental pathology and subsequently poor pregnancy outcome (7,8).Cerebral malaria (CM) or respiratory distress syndrome has been reported to be an infrequent but relevant cause of maternal death in women living in an area of sub-Saharan Africa where m...

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Section: Discussionmentioning

confidence: 99%

Development of Severe Pathology in Immunized Pregnant Mice Challenged with Lethal Malaria Parasites

et al. 2013

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“…It lives as a parasite in other organisms, namely man and mosquito. The plasmodium parasite is dependent on a single species of mosquito, anopheles, which is the only species capable of serving as the host of it (Ducarme, 2008…”

Section: Life Cycle Of Malaria Parasite In Nigeriamentioning

confidence: 99%

“…Knowledge is one of the important elements in any effort targeted towards the reduction of disease burden such as malaria (Minnesota Health Acrim Team, 2010) (Ducarme et al;2008) reported that the failure to establish the level of knowledge of community members regarding malaria appeared to be responsible for the mobility of intervention programmes to achieve suitable control. Consequently every women is expected to possess an appreciable level of knowledge of the cause, breeding sources, mode of transmission, consequences and prevention for successful eradicative of the disease in any given community.…”

Section: Introductionmentioning

confidence: 99%

Awareness and Preventions of Malaria in Pregnant Women: A Study of Mile Four Hospital, Nigeria

G¹

2018

TIJPH

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This cross sectional study was conducted at the maternity unit of Mile Four Hospital in Abakaliki Ebonyi State. The aim was to determine the degree of awareness and practice of malaria prevention strategies among antenatal attendees in Mile Four Hospital in Abakaliki Ebonyi State. Semistructured questionnaires were administered to one thousand five hundred and sixteen pregnant women in the antenatal clinic. The findings revealed among other things that pregnant women attending antenatal clinic in Mile Four Hospital Abakaliki in Ebonyi State are aware of malaria preventive measures and are utilizing malaria preventive measures to prevent themselves. The study recommended among other things that, awareness campaign should be drawn to rural areas so that Pregnant women should be educate on high risk involve in malaria infestation for total eradication of miscarriage, low birth weight, still birth and maternal death.

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“…At the travel destination, infectious diseases, such as malaria, Zika, and SARS-CoV-2, pose risks to pregnant people and their fetuses [2][3][4][5][6][7]. Pregnant people are more likely to attract mosquitoes that can cause malaria and Zika than their non-pregnant counterparts [8,9], and pregnant people have more severe malaria infections, as well as increased risk for developing pregnancy-specific complications, including preterm birth, low birth weight, congenital infection, miscarriage, stillbirth, and death [10][11][12][13][14][15][16][17]. Zika can cause fetal anomalies, including severe fetal brain injury, fetal growth restriction, miscarriages, and stillbirths, as well as ocular changes and hearing loss [7,[18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Travel during Pregnancy: A Web-Based Survey of People Who Have Been Pregnant within the Past 10 Years

Nechval,

Antony

2023

Reprod. Med.

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Travel is frequent among many populations, including pregnant people. The focus of this online survey was to better understand the travel practices of people who have been pregnant within the last ten years. An online survey was conducted for three months through social media posts on Facebook and Twitter. Previously pregnant people were asked questions about where they traveled, if they cancelled any travel plans, and travel-related discussions with their obstetric provider. During the three months the survey was open, 469 participants completed the survey. A total of 390 (83.2%) participants traveled domestically, while 114 (24.3%) traveled internationally or between non-contiguous states within the United States of America (USA). Of these respondents, 170 (44.2%) of the domestic travelers and 69 (61.1%) of the international travelers reported discussing travel plans with their OB provider. Additionally, 49 (10.5%) participants cancelled at least one domestic trip and 30 (6.41%) cancelled at least one international trip. Regarding travel discussions, 6 (3.6%) participants who traveled domestically and 2 (2.9%) who traveled internationally reported that their OB provider initiated the conversation. Many pregnant people choose to travel domestically and internationally. However, it is also clear that not all travelers discuss plans with their OB provider, and in few cases does the provider initiate the conversation. Given the frequency with which people travel, pregnant people and their OB providers should have conversations regarding travel to minimize potential risks.

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Malaria in Pregnant Woman Masquerading as HELLP Syndrome

Cited by 9 publications

References 8 publications

Development of Severe Pathology in Immunized Pregnant Mice Challenged with Lethal Malaria Parasites

Development of Severe Pathology in Immunized Pregnant Mice Challenged with Lethal Malaria Parasites

Awareness and Preventions of Malaria in Pregnant Women: A Study of Mile Four Hospital, Nigeria

Travel during Pregnancy: A Web-Based Survey of People Who Have Been Pregnant within the Past 10 Years

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