Malaria: influence of Anopheles mosquito saliva on Plasmodium infection

Arora, Gunjan; Chuang, Yu-Min; Sinnis, Photini; Dimopoulos, George; Fikrig, Erol

doi:10.1016/j.it.2023.02.005

Cited by 18 publications

(8 citation statements)

References 77 publications

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“…These abnormal values observed in the plasma of the infected mice suggests anemia resulting from the destruction of erythrocytes (RBCs). The breakdown of the erythrocytes may involve antibody-dependent cell mediated cytotoxicity (ADCC), 35 or Opsonin-independent killing mechanism. 36 Acute anemia in P.berghei infested mice as revealed in this study could be due to increased myeloid cell production resulting from immune response of the cells to parasitic infection resulting to inhibition of erythroid development.…”

Section: Resultsmentioning

confidence: 99%

In-vivo and Histological Studies of Matrix-based Artemether-Lumefantrine Oral Tablets Derived from Cissus populnea Gum

2024

TJNPR

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Malaria incidences has been a public health concern and it has increased in recent years because of resistance of the malaria parasite to available antimalarial drugs. This research explored the anti-plasmodial effect of the Cissus populnea matrixed in artemether-lumefantrine against Plasmodium berghei infected mice. The matrixed drug was evaluated for prophylactic, curative, and suppressive effect in Plasmodium berghei mice. The swiss Albino mice were grouped into 4 and were inoculated with Plasmodium berghei intraperitoneally except the naïve group. The matrixed drug significantly inhibited parasitemia in prophylactic, curative, and suppressive infections (p<0.05) (45.75%, 37.75, and 60.99%, respectively). However, a significant decrease in PCV, Hb, RBC and increased total and differential white blood cell count was observed in the mice that were treated with the matrixed tablet formulation for prophylaxis and suppression, but no significant hematological effect was observed in the groups that received the matrixed tablet for curative effect. The histopathological analysis of the matrixed drug on different organs showed no observable damage in any of the organs This study suggests that incorporation of Cissus populnea gum in artemether-lumefantrine based tablets possessed promising antimalarial potential with minimal histological and hematological effects.

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Section: Resultsmentioning

confidence: 99%

In-vivo and Histological Studies of Matrix-based Artemether-Lumefantrine Oral Tablets Derived from Cissus populnea Gum

2024

TJNPR

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“…However, little is known about parasite antigens that could be expressed in the mosquito and released in the saliva 59 . Therefore, these ndings open new avenues to studying the mosquito-parasite interaction.…”

Section: Discussionmentioning

confidence: 99%

Human sterile immunity to Plasmodium vivax malaria correlates with specific antibody response elicited by immunization with radiation-attenuated sporozoites

Lopez-Perez,

Jain,

Davies

et al. 2023

Preprint

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Malaria sterile immunity has been reproducibly induced by immunization with Plasmodium radiation-attenuated sporozoites (RAS). Analyses of sera from RAS-immunized individuals allowed the identification of P. falciparum antigens, such as the circumsporozoite protein (CSP), the basis for the RTS, S vaccine. Similar advances in P. vivax (Pv) vaccination have been elusive. We previously reported 42% (5/12) of sterile protection in malaria-unexposed, Duffy-positive (Fy+) volunteers immunized with PvRAS followed by a controlled human malaria infection (CHMI). Using a custom protein microarray displaying 515 Pv antigens, we found that PvRAS group seroreactivity was lower in protected than non-protected volunteers. Nevertheless, protected volunteers showed higher reactivity to PvCSP and other antigens. In Fy- volunteers immunized with non-irradiated Pv-infected mosquitoes, parasite reactivity increased throughout immunizations. Mock-vaccinated Fy + volunteers developed a vigorous response to CHMI. These findings allowed the identification of novel parasite antigens currently being pursued as vaccine candidates.

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“…and transmitted by mosquitoes of the Anopheles spp. genus [23]. Despite numerous efforts, the World Health Organization (WHO) acknowledges that insufficient progress has been made towards its eradication [24].…”

Section: Discussionmentioning

confidence: 99%

In Silico Studies of Four Compounds of Cecropia obtusifolia against Malaria Parasite

Lobato-Tapia,

Moreno-Hernández,

Olivo-Vidal

2023

Molecules

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Malaria is a disease that affects many people in the world. In Mexico, malaria remains an active disease in certain regions, particularly in the states of Chiapas and Chihuahua. While antimalarial effects have been attributed to some species of Cecropia in various countries, no such studies have been conducted in Mexico. Therefore, the objective of this study was to evaluate the in silico antimalarial activity of some active compounds identified according to the literature in the species of Cecropia obtusifolia, belonging to the Cecropiaceae family, such as ursolic acid, α-amyrin, chrysin, and isoorientin. These compounds were evaluated with specific molecular docking and molecular dynamics (MD) studies using three different malarial targets with the PDB codes 1CET, 2BL9, and 4ZL4 as well as the prediction of their pharmacokinetic (Pk) properties. Docking analysis revealed the following best binding energies (kcal/mol): isoorientin–1CET (−9.1), isoorientin–2BL9 (−8.8), and chrysin–4ZL4 (−9.6). MD simulation validated the stability of the complexes. Pharmacokinetics analysis suggested that the compounds would generally perform well if administered. Therefore, these results suggest that these compounds may be used as potential drugs for the treatment of malaria.

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Malaria: influence of Anopheles mosquito saliva on Plasmodium infection

Cited by 18 publications

References 77 publications

In-vivo and Histological Studies of Matrix-based Artemether-Lumefantrine Oral Tablets Derived from Cissus populnea Gum

In-vivo and Histological Studies of Matrix-based Artemether-Lumefantrine Oral Tablets Derived from Cissus populnea Gum

Human sterile immunity to Plasmodium vivax malaria correlates with specific antibody response elicited by immunization with radiation-attenuated sporozoites

In Silico Studies of Four Compounds of Cecropia obtusifolia against Malaria Parasite

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