Malaria

Poespoprodjo, Jeanne Rini; Douglas, Nicholas M; Ansong, Daniel; Kho, Steven; Anstey, Nicholas M

doi:10.1016/s0140-6736(23)01249-7

Cited by 59 publications

(12 citation statements)

References 210 publications

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“…Malaria remains a major global health challenge (1,2). Much work has investigated how the coincident challenge of climate change threatens progress to malaria control (1).…”

Section: Main Textmentioning

confidence: 99%

Evidence from Madagascar shows that vaccination could mitigate climate-driven disruptions to malaria control

Rice,

Raobson,

Miharisoa

et al. 2024

Preprint

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Increasingly extreme weather events in high malaria burden areas threaten progress to disease control targets. Yet, data on the impact of these events on control programs remain rare. Using unique data from Madagascar, we estimate high rates of infection in the wake of two major tropical cyclones. Evidence that infection rebounds rapidly during gaps in interventions indicates maintaining continuity of coverage is crucial to limiting burden. Relative to other interventions, recently available malaria vaccines have a longer duration of protection, with the potential to address interruptions in prevention deployment. Evaluating this use case, we quantify the reduction in symptomatic infections expected for a range of vaccination scenarios. We find long-lasting interventions such as vaccination are a key mitigation measure against climatic disruptions to disease control.

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“…Malaria remains a major global health challenge (1,2). Much work has investigated how the coincident challenge of climate change threatens progress to malaria control (1).…”

Section: Main Textmentioning

confidence: 99%

Evidence from Madagascar shows that vaccination could mitigate climate-driven disruptions to malaria control

Rice,

Raobson,

Miharisoa

et al. 2024

Preprint

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“…Malaria is a vector-borne disease caused by infection with parasitic protozoa of the Plasmodium genus, which continues to exert a high health burden and cost in endemic settings [1, 2]. Six Plasmodium species commonly cause malaria in humans: P. falciparum, P. vivax, P. malariae, P. ovale walikeri , P. ovale curtisi and P. knowlesi [3]. Since P. falciparum and P. vivax have historically caused the most significant health burden in humans, elimination efforts have primarily focused on these species [4].…”

Section: Introductionmentioning

confidence: 99%

The economic burden of zoonoticPlasmodium knowlesimalaria on households in Sabah, Malaysia compared to malaria from human-onlyPlasmodiumspecies

Abraham,

McMullin,

William

et al. 2024

Preprint

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Background: The emergence of the zoonotic monkey parasite Plasmodiumknowlesi as the dominant cause of malaria in Malaysia has disrupted current national WHO elimination goals. Malaysia has free universal access to malaria care; however, out-of-pocket costs are unknown. This study estimated household costs of illness attributable to malaria due to P. knowlesi against other non-zoonotic Plasmodium species infections in Sabah, Malaysia. Methodology/Principal Findings: Household costs were estimated from patient-level surveys collected from four hospitals between 2013 and 2016. Direct costs including medical and associated travel costs, and indirect costs due to lost productivity were included. One hundred and fifty-two malaria cases were enrolled: P. knowlesi (n=108), P. vivax (n=22), P. falciparum (n=16), and P. malariae (n=6). Costs were inflated to 2022 Malaysian Ringgits and reported in United States dollars (US$). Across all cases, the mean total costs were US$138 (SD=108), with productivity losses accounting for 58% of costs (US$80; SD=73). P. vivax had the highest mean total household cost at US$210, followed by P. knowlesi (US$127), P. falciparum (US$126), and P. malariae (US$105). Most patients (80%) experienced direct health costs above 10% of monthly income, with 58 (38%) patients experiencing health spending over 25% of monthly income, consistent with catastrophic health expenditure. Conclusions/Significance: Despite Malaysia's free health-system care for malaria, patients and families face other related medical, travel, and indirect costs. Household out-of-pocket costs were driven by productivity losses; primarily attributed to infections in working-aged males in rural agricultural-based occupations. Costs for P. knowlesi were comparable to P. falciparum and lower than P. vivax. The higher P. vivax costs related to direct health facility costs for repeat monitoring visits given the liver-stage treatment required.

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“…Once released from the hepatocytes, the parasites actively invade erythrocytes, thereby starting the erythrocytic replication cycle, during which they multiply inside erythrocytes and subsequently invade new red blood cells. The repeating burst of erythrocytes is responsible for symptoms like fever and anemia and, in severe cases, can lead to organ failure and death (reviewed in [ 2 ]).…”

Section: Introductionmentioning

confidence: 99%

The Multiple Roles of LCCL Domain-Containing Proteins for Malaria Parasite Transmission

Bennink,

Pradel

2024

Microorganisms

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Multi-protein complexes are crucial for various essential biological processes of the malaria parasite Plasmodium, such as protein synthesis, host cell invasion and adhesion. Especially during the sexual phase of the parasite, which takes place in the midgut of the mosquito vector, protein complexes are required for fertilization, sporulation and ultimately for the successful transmission of the parasite. Among the most noticeable protein complexes of the transmission stages are the ones formed by the LCCL domain-containing protein family that play critical roles in the generation of infective sporozoites. The six members of this protein family are characterized by numerous adhesive modules and domains typically found in secreted proteins. This review summarizes the findings of expression and functional studies on the LCCL domain-containing proteins of the human pathogenic P. falciparum and the rodent-infecting P. berghei and discusses the common features and differences of the homologous proteins.

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Malaria

Cited by 59 publications

References 210 publications

Evidence from Madagascar shows that vaccination could mitigate climate-driven disruptions to malaria control

Evidence from Madagascar shows that vaccination could mitigate climate-driven disruptions to malaria control

The economic burden of zoonoticPlasmodium knowlesimalaria on households in Sabah, Malaysia compared to malaria from human-onlyPlasmodiumspecies

The Multiple Roles of LCCL Domain-Containing Proteins for Malaria Parasite Transmission

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