Malaria-related hospitalization during childhood in Papua, Indonesia: A retrospective cohort study

Abstract

Background In endemic regions, the age distribution of malaria varies according to the infecting Plasmodium species. We aimed to delineate the pattern of malaria-related hospitalization from birth in Timika, Papua-an area co-endemic for P. falciparum and P. vivax Methods Between April 2004 and December 2013, infants born at Mitra Masyarakat Hospital, or presenting within the first 7 days of life, were enrolled retrospectively into a cohort study and followed passively using routinely-collected hospital surveillance data. Outcomes were stratified by the presence or absence of Plasmodium parasitemia and included representation to hospital, requirement for hospital admission and death. Results Overall, 11,408 infants were enrolled into the cohort. Median follow-up was 4.3 (maximum 9.7) years. In total, 7,847 (68.9%) infants made 90,766 representations to hospital, 18,105 (19.9%) of which were associated with Plasmodium parasitemia. The incidence of representations with malaria during the first year of life was 213 per 1,000 person-years (py) for P. vivax and 79 per 1,000py for P. falciparum (Incidence Rate Ratio (IRR) = 2.69, 95% Confidence Interval (95%CI): 2.48-2.92). After the age of 5 years, the incidence of P. vivax had fallen to 77/1,000py and the incidence of P. falciparum had risen to 95/1,000py (IRR = 0.80, 95%CI: 0.73-0.88). Overall, 79.7% (14,431/18,105) of malaria representations were recurrences rather than initial infections. Malaria accounted for 31.7% (2,126/3,120) of all hospital

Ten years malaria trend analysis in Mangili Public Health Centre, East Sumba District of East Nusa Tenggara Province, Indonesia: a retrospective study

“…This study showed that the prevalence of plasmodium falciparum was higher than plasmodium vivax. This consistent with the national report of Indonesia government (5) and study in many parts of Indonesia (14,(16)(17)(18) and other countries including Ethiopia (19), Northwest Ethiopia (20) Saudi Arabia (21) , but this contrast with study in Mauritania (22) indicating the prevalence of malaria vivax was higher than falciparum. In this study, the prevalence of plasmodium falciparum shows a decreased trend from year to year, however the number of the cases was still high until the end of period under review.…”

Low-level Plasmodium vivax exposure, maternal antibodies, and anemia in early childhood: Population-based birth cohort study in Amazonian Brazil

“…vivax is the second most prevalent human malaria parasite worldwide [2]. It is mostly absent from Central and West Africa, but causes significant morbidity in children elsewhere in the tropics [8][9][10]. More malaria-related hospital admissions in infants and toddlers are due to P. vivax than P. falciparum in the Asia-Pacific region, where both species are co-transmitted Antimalarial Resistance Network (WWARN) Data Platform, hosted by the University of Oxford, as part of the Impact of Malaria in Pregnancy on Infants Study Group.…”