Malaria vaccine: The lasting solution to malaria burden in Africa

Adeyemo, Abidemi Olugbenga; Aborode, Abdullahi Tunde; Bello, Munira Aminu; Obianuju, Agwuna Favour; Hasan, Mohammad Mehedi; Kehinde, Dada Oluwasogo; Hossain, Md. Shahadat; Bardhan, Mainak; Imisioluwa, Jegede Oluwatoyin; Akintola, Ashraf Akintayo

doi:10.1016/j.amsu.2022.104031

Cited by 10 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lack of comprehensive data on malaria vaccine efficacy also complicates decision-making on funding and implementing vaccination campaigns. [ 34 , 35 ] More thorough data are needed on the effectiveness of malaria vaccines in real-world situations rather than just pilot or demonstration projects. [ 5 ] Further data are also needed on the cost-effectiveness of malaria vaccination programs in Africa, without which convincing donors and policymakers for funding and other resource allocation is much more difficult.…”

Section: Methodsmentioning

confidence: 99%

Malaria vaccination in Africa: A mini-review of challenges and opportunities

Olawade,

Wada,

Ezeagu

et al. 2024

Medicine

View full text Add to dashboard Cite

Malaria remains an endemic public health concern in Africa, significantly contributing to morbidity and mortality rates. The inadequacies of traditional prevention measures, like integrated vector management and antimalarial drugs, have spurred efforts to strengthen the development and deployment of malaria vaccines. In addition to existing interventions like insecticide-treated bed nets and artemisinin-based combination therapies, malaria vaccine introduction and implementation in Africa could drastically reduce the disease burden and hasten steps toward malaria elimination. The malaria vaccine rollout is imminent as optimistic results from final clinical trials are anticipated. Thus, determining potential hurdles to malaria vaccine delivery and uptake in malaria-endemic regions of sub-Saharan Africa will enhance decisions and policymakers’ preparedness to facilitate efficient and equitable vaccine delivery. A multisectoral approach is recommended to increase funding and resources, active community engagement and participation, and the involvement of healthcare providers.

show abstract

Section: Methodsmentioning

confidence: 99%

Malaria vaccination in Africa: A mini-review of challenges and opportunities

Olawade,

Wada,

Ezeagu

et al. 2024

Medicine

View full text Add to dashboard Cite

show abstract

“…Malaria, a communicable disease caused by the Plasmodium parasite and transmitted through Anopheles mosquitoes, is a significant global health concern 1 , 2 . The World Health Organization (WHO) emphasizes key pillars for effective malaria prevention and control, with a crucial focus on ensuring universal access to prevention, diagnosis, and treatment 3 , 4 .…”

Section: Introductionmentioning

confidence: 99%

Factors influencing delay in malaria treatment seeking at selected public health facilities in South Gonder, Ethiopia

Alga,

Wasihun,

Ayele

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Early and prompt treatment-seeking for malaria is necessary to reduce the progression of the disease to its severe forms and the associated mortality. Various studies have indicated that treatments sought for malaria were not always within the recommended timeframe. Therefore, this study aims to assess factors influencing delay in malaria treatment seeking at public health facilities in South Gonder, Ethiopia. An unmatched case–control study was conducted among 322 individuals, comprising 161 cases and 161 controls, who were randomly selected malaria patients visiting public health facilities in South Gonder District, Ethiopia, from May 20/2022 to June 25/2022. An interviewer-administered questionnaire was used to collect data, which were subsequently cleaned and entered into Epi data. Descriptive statistics were performed, and variables with a p-value of ≤ 0.25 from the bivariate analysis were included in a multivariable logistic regression model. Significant variables with a p-value of < 0.05 were retained in the multivariable model. Patients who were unable to read and write [AOR = 3.47 (1.01–11.9)], fear of side effects of malaria treatment drugs [AOR = 1.89 (1.04–3.42)], lack of access to health education malaria disease and its treatment [AOR = 1.93 (1.02–3.65)], lack of transportation access [AOR = 4.70 (1.73–12.7)], not membership of community-based health insurance [AOR = 2.5 (1.3–4.82)] and lack of confidence on malaria care health facility providing [AOR = 2.14 (1.06–4.29)], were found to be determinants of treatment-seeking delay among malaria patients. In Summary, this study revealed significant associations between delays in seeking malaria treatment and factors such as educational status (those who were unable to read and write), malaria drug side effects, health education on malaria, transportation access, CBHI membership, and confidence in health malaria care. it is recommended that targeted interventions and awareness campaigns be implemented to address these determinants, promoting prompt and effective malaria treatment-seeking behavior in the studied population.

show abstract

“…regulators, suppliers, prescribers and end-users) starting from early stages of evidence generation to the final stage of uptake is central. [ 7 , 8 ]. This manuscript is predicated on current evidence from Southeast Asia [ 9 ] regarding resistance to artemisinin and partner drugs with resultant failure of ACT, and the recent reports of artemisinin partial resistance from three African countries [ 10 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

A framework for stakeholder engagement in the adoption of new anti-malarial treatments in Africa: a case study of Nigeria

Mokuolu

Bolarinwa

Opadiran³

et al. 2023

Malar J

View full text Add to dashboard Cite

Background Recent reports of artemisinin partial resistance from Rwanda and Uganda are worrisome and suggest a future policy change to adopt new anti-malarials. This is a case study on the evolution, adoption, and implementation of new anti-malarial treatment policies in Nigeria. The main objective is to provide perspectives to enhance the future uptake of new anti-malarials, with an emphasis on stakeholder engagement strategies. Methods This case study is based on an analysis of policy documents and stakeholders’ perspectives drawn from an empirical study conducted in Nigeria, 2019–2020. A mixed methods approach was adopted, including historical accounts, review of programme and policy documents, and 33 qualitative in-depth interviews and 6 focus group discussions. Results Based on policy documents reviewed, the adoption of artemisinin-based combination therapy (ACT) in Nigeria was swift due to political will, funding and support from global developmental partners. However, the implementation of ACT was met with resistance from suppliers, distributors, prescribers, and end-users, attributed to market dynamics, costs and inadequate stakeholder engagement. Deployment of ACT in Nigeria witnessed increased developmental partner support, robust data generation, ACT case-management strengthening and evidence on anti-malarial use in severe malaria and antenatal care management. A framework for effective stakeholder engagement for the future adoption of new anti-malarial treatment strategies was proposed. The framework covers the pathway from generating evidence on drug efficacy, safety and uptake; to making treatment accessible and affordable to end-users. It addresses which stakeholders to engage with and the content of engagement strategies with key stakeholders at different levels of the transition process. Conclusion Early and staged engagement of stakeholders from global bodies to community level end-users is critical to the successful adoption and uptake of new anti-malarial treatment policies. A framework for these engagements was proposed as a contribution to enhancing the uptake of future anti-malarial strategies.

show abstract

Malaria vaccine: The lasting solution to malaria burden in Africa

Cited by 10 publications

References 21 publications

Malaria vaccination in Africa: A mini-review of challenges and opportunities

Malaria vaccination in Africa: A mini-review of challenges and opportunities

Factors influencing delay in malaria treatment seeking at selected public health facilities in South Gonder, Ethiopia

A framework for stakeholder engagement in the adoption of new anti-malarial treatments in Africa: a case study of Nigeria

Contact Info

Product

Resources

About