Malaria vector control strategies. What is appropriate towards sustainable global eradication?

Ogunah, Joanne Atieno; Lalah, Joseph O.; Schramm, Karl‐Werner

doi:10.1016/j.scp.2020.100339

Cited by 13 publications

(7 citation statements)

References 266 publications

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“…There is strong evidence to suggest that environmental management and LSM are important interventions for outdoor biting [ 116 – 118 ] and are critical in the elimination of malaria in many countries. In addition, once effectively implemented and monitored, these interventions have many aspects that are more sustainable than the current conventional malaria prevention interventions [ 119 ]. Similar to the other malaria prevention interventions presented in this review, environmental management and LSM do not rely on individual or daily compliance to be successful.…”

Section: Discussionmentioning

confidence: 99%

Malaria prevention interventions beyond long-lasting insecticidal nets and indoor residual spraying in low- and middle-income countries: a scoping review

Nalinya

Musoke

Deane

2022

Malar J

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Background Significant progress in malaria prevention during the past two decades has prompted increasing global dialogue on malaria elimination. Recent reviews on malaria strategies have focused mainly on long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), with little emphasis on other prevention methods. This article is a scoping review of literature on malaria prevention methods beyond LLINs and IRS in low- and middle-income countries (LMICs). Methods This scoping review found articles published between from 1994 to 2020. Studies were obtained from a search of the PubMed, the Cochrane Library and Social Science abstracts. Grey literature and manual search of secondary references was also done. The search strategy included all study designs but limited only to English. Three independent reviewers performed the selection and characterization of articles, and the data collected were synthesized qualitatively. Results A total of 10,112 studies were identified among which 31 met the inclusion criteria. The results were grouped by the 3 emerging themes of: housing design; mosquito repellents; and integrated vector control. Housing design strategies included closing eves, screening of houses including windows, doors and ceilings, while mosquito repellents were mainly spatial repellents, use of repellent plants, and use of plant-based oils. Integrated vector control included larvae source management. Evidence consistently shows that improving housing design reduced mosquito entry and malaria prevalence. Spatial repellents also showed promising results in field experiments, while evidence on repellent plants is limited and still emerging. Recent literature shows that IVM has been largely ignored in recent years in many LMICs. Some malaria prevention methods such as spatial repellents and IVM are shown to have the potential to target both indoor and outdoor transmission of malaria, which are both important aspects to consider to achieve malaria elimination in LMICs. Conclusion The scoping review shows that other malaria prevention strategies beyond LLINs and IRS have increasingly become important in LMICs. These methods have a significant role in contributing to malaria elimination in endemic countries if they are adequately promoted alongside other conventional approaches.

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Section: Discussionmentioning

confidence: 99%

Malaria prevention interventions beyond long-lasting insecticidal nets and indoor residual spraying in low- and middle-income countries: a scoping review

Nalinya

Musoke

Deane

2022

Malar J

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“…Various strategies for controlling mosquito vector species have been employed globally and they continue to evolve. These include chemical insecticides that focus on the elimination of malaria vectors utilizing various kinds of chemical insecticides [ 61 ], destruction or control of the environment for larvae, larviciding with insecticides, the use of biological agents, and rotational use of insecticides to avoid the emergence of tolerance/resistance in populations of mosquitoes [ 62 ]. Innovative methods for malaria control, such as field investigations, laboratory-based research, and vector control evaluation, in endemic communities, could leverage on species identification, as well as applying the right kind of insecticide, as ways of preventing over-exposure that could result in insecticide resistance and other downstream complications.…”

Section: Mosquito Control Strategiesmentioning

confidence: 99%

Revolutionizing Malaria Vector Control: The Importance of Accurate Species Identification through Enhanced Molecular Capacity

Hadebe,

Malgwi,

Okpeku

2023

Microorganisms

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Many factors, such as the resistance to pesticides and a lack of knowledge of the morphology and molecular structure of malaria vectors, have made it more challenging to eradicate malaria in numerous malaria-endemic areas of the globe. The primary goal of this review is to discuss malaria vector control methods and the significance of identifying species in vector control initiatives. This was accomplished by reviewing methods of molecular identification of malaria vectors and genetic marker classification in relation to their use for species identification. Due to its specificity and consistency, molecular identification is preferred over morphological identification of malaria vectors. Enhanced molecular capacity for species identification will improve mosquito characterization, leading to accurate control strategies/treatment targeting specific mosquito species, and thus will contribute to malaria eradication. It is crucial for disease epidemiology and surveillance to accurately identify the Plasmodium spp. that are causing malaria in patients. The capacity for disease surveillance will be significantly increased by the development of more accurate, precise, automated, and high-throughput diagnostic techniques. In conclusion, although morphological identification is quick and achievable at a reduced cost, molecular identification is preferred for specificity and sensitivity. To achieve the targeted malaria elimination goal, proper identification of vectors using accurate techniques for effective control measures should be prioritized.

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“…Another use of pesticides, of course, is to control vector-borne diseases such as malaria and sleeping sickness [7,[11][12][13][14]. Insecticides help to restrict diseases geographically by killing the hosts of pathogens.…”

Section: Dilemma Of Using Pesticidesmentioning

confidence: 99%

“…Increased reactive oxygen species (ROS) levels as a result of pesticide usage and exposure can be associated with imbalances in cell homeostasis, which in turn, affects cellular components and DNA stability, and causes genotoxicity [42,[44][45][46][47][48]. A positive correlation between the incidence of various types of cancers such as leukemia, lung, and ovarian cancer as dependent variable and exposure to pesticides has been shown in many studies [13,29,30]. Besides the serious environmental and public health issues, different pest species have developed resistance to these chemicals, which leads to significant reduction in their effectiveness.…”

Section: Accepted Articlementioning

confidence: 99%

Are insect GPCRs ideal next‐generation pesticides: opportunities and challenges

et al. 2021

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The increasing human population, combined with low inefficiency and adverse effects of available pesticides, has magnified the urgent need of developing next-generation pesticides. Among the available approaches, strategies targeting invertebrate G protein-coupled receptors (GPCRs) are very promising as these receptors are the targets of endogenous neuropeptides/neuromodulators that upon binding to their receptors induce profound changes in insect physiology. Therefore, exploring GPCR regulators has great potential in the development of targeted next-generation pesticides. Despite the great potential of such alternative pesticides, so far there has been only one approved compound, Amitraz, which conveys its antipest activity via the GPCR Octopamine receptor. Here, we review the current status of pesticide development, hazards associated with conventional pesticide compounds, alternative strategies that involve next-generation of pesticides, structural features of GPCRs, and opportunities and challenges of targeting the members of this superfamily in invertebrates to develop anti-pest agents. In conclusion, we emphasize that the potential of GPCRs cannot be utilized in full without more genomic and transcriptomic data to improve our understanding of the complex network of peptidergic signaling pathways. We argue how vital it is to obtain three-dimensional (3D) structural data on physiologically important target GPCRs and encourage the readers to use the state of the art in silico methods such as virtual screening for the discovery of new pesticide compounds.

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Malaria vector control strategies. What is appropriate towards sustainable global eradication?

Cited by 13 publications

References 266 publications

Malaria prevention interventions beyond long-lasting insecticidal nets and indoor residual spraying in low- and middle-income countries: a scoping review

Malaria prevention interventions beyond long-lasting insecticidal nets and indoor residual spraying in low- and middle-income countries: a scoping review

Revolutionizing Malaria Vector Control: The Importance of Accurate Species Identification through Enhanced Molecular Capacity

Are insect GPCRs ideal next‐generation pesticides: opportunities and challenges

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