Malarial anaemia in African children associated with high oxygen-radical production

Kremsner, P. G.; Greve, Bernhard; Lell, Bertrand; Luckner, Doris; Schmid, Daniela

doi:10.1016/s0140-6736(99)04761-3

Cited by 73 publications

(51 citation statements)

References 5 publications

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“…Invasion of the human erythrocytes by the malarial parasite is accompanied by a variety of biological responses in the human host and in order to survive, the plasmodium parasite brings about considerable metabolic changes in the host cell. The host cells may then become more vulnerable to damage due to toxic metabolites derived from both the host and the parasite through the basic pathophysiology involved in the RBC destruction [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Acid Phosphatase as a Marker in Malaria

et al. 2011

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The serum acid phosphatase (ACP) activity and Hemoglobin (Hb) levels were measured in malaria patients and nonmalarial fever patients. The results were compared with normal healthy control subjects. ACP was significantly increased (P \ 0.001) in all the malaria patients. ACP was significantly higher in Plasmodium falcifarum malaria and mixed malaria when compared to Plasmodium vivax malaria. Hb levels were significantly decreased in all the malaria patients which indicates that malaria parasite uses host erythrocyte Hb as a major nutrient source. There is negative correlation(r = -0.478) between ACP and Hb in malaria patients, which is highly significant. These results suggest that the measurement of ACP could be used as a marker for malaria.

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Section: Discussionmentioning

confidence: 99%

Acid Phosphatase as a Marker in Malaria

et al. 2011

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“…It is not known whether improved carotenoid status, either through dietary intervention or supplementation, will improve clinical outcomes of acute malaria. Severe malarial anemia has been associated with high oxygen-radical production in African children, 24 and it is unclear whether antioxidant effects of micronutrients could help to modulate anemia. The present study is limited in that indicators of oxidative stress, such as plasma thiobarbituric acid-reactive material or plasma malondialdehyde, were not measured.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant status and acute malaria in children in Kampala, Uganda.

Metzger¹,

Mukasa²,

Shankar³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

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Abstract. Although antioxidant status has been implicated in the pathogenesis of malaria, these factors need further characterization. A longitudinal study was conducted involving 273 children 1-10 years of age with acute, uncomplicated malaria in Kampala, Uganda. Plasma vitamin A, carotenoids, and vitamin E were measured at enrollment and on day 7. Malaria parasitemia was measured at enrollment, on day 3, and on day 7. Malaria parasitemia had completely cleared in 57.1% and 85.3% of children by day 3 and day 7, respectively. Plasma vitamin A, ␣-carotene, ␤-carotene, lycopene, lutein/zeaxanthin, and vitamin E were depressed at enrollment and increased by day 7. Multivariate analyses showed that higher plasma lycopene concentrations at enrollment were associated with clearance of parasitemia between enrollment and day 3 (odds ratio ϭ 1.46, 95% confidence interval ϭ 1.07-2.06, per 0.10 mol/L of lycopene). This study suggests that children with acute malaria have depressed plasma concentrations of antioxidants, and that higher plasma lycopene is associated with more rapid clearance of malaria parasitemia.

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“…Rath etal (6) reported an increased levels of serum lipid peroxidation in P.falciparum infected patients as compared to P. vivax infection. In addition to this, phagocytosis of malarial pigment or pigment containing erythrocytes by phagocytes,results in release of large number of reactive oxygen intermediates for a short period (4). Besides this, the plasma of malaria patients has been suspected Indian Journal of Clinical Biochemistry, 2003 136-149 to contain prooxidants.…”

Section: Ii) Enhancement Of Oxidant Status In Malaria Patientsmentioning

confidence: 99%

“…One of the major reasons for development of maladal anemia seems to be oxidative stress (3,4). Any infection, including malaria, activates the immune system of body thereby causing release of reactive oxygen species as an antimicrobial action.…”

Section: Introductionmentioning

confidence: 99%

Studies on biochemical changes with special reference to oxidant and antioxidants in malaria patients

Kulkarni

Suryakar

Sardeshmukh

et al. 2003

Indian J Clin Biochem

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Oxidative stress plays an important role in the development of maladal anemia. The present study was undertaken to study the role of oxidant and antioxidants in the patients of Plasmodium falciparum malada (n = 25), Plasmodium vivax malada (n = 25) as against the normal control subjects (n =25). The parameters included are the hematological [hemoglobin, erythrocyte adenosine deaminase (ADA) activity, ADP -induced platelet aggregation] and serum total lipid peroxide as an index of oxidative stress and antioxidants [erythrocytic superoxide dismutase (SOD) activity, serum vitamin E] & serum iron.Significant alterations in all above parameters were noted in both groups of malaria patients as compared to control subjects. Maximum significant alterations in hematological parameters were noticed in P. falciparum infection as compared to P. vivax malada (p<0.001). Substantial dse in serum total lipid peroxides and a significant reduction in antioxidants such as serum vitamin E and serum iron were noted in R falciparum malaria as compared to R vivax malada (p< 0.001), whereas maximum decline in erythrocytic SOD activity was observed in R vivax infection as compared to R falciparum malaria (p<0.05). Follow-up examination revealed the restoration of the levels of all biochemical parameters to the normal level after 20 days of antimalarial therapy.The study specified severity of P. falciparum malaria and also functional duality of oxidant.

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Malarial anaemia in African children associated with high oxygen-radical production

Cited by 73 publications

References 5 publications

Acid Phosphatase as a Marker in Malaria

Acid Phosphatase as a Marker in Malaria

Antioxidant status and acute malaria in children in Kampala, Uganda.

Studies on biochemical changes with special reference to oxidant and antioxidants in malaria patients

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