Malassezia furfur-related colonization and infection of central venous catheters

Sizun, Jacques; Karangwa, A.; Giroux, J. D.; Masure, O.; Simitzis, A. M.; Alix, D; Parscau, L. De

doi:10.1007/bf01711902

Cited by 27 publications

(16 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…44 Notably, current routine methods for yeast identification may be insufficient to identify isolates of lipophilic Malassezia species, which have been found to be associated to a low but not negligible extent with infection of central venous catheters for parenteral nutrition-bearing lipid emulsions. 45 Alpert et al 46 reported Malassezia furfur fungemia in infancy, including a patient with evidence of endocarditis. In addition, Aspergillus species frequently found in patients after cardiovascular surgery account for a high percentage of fungal IEs.…”

Section: Discussionmentioning

confidence: 99%

Impact of a Molecular Approach to Improve the Microbiological Diagnosis of Infective Heart Valve Endocarditis

et al. 2005

View full text Add to dashboard Cite

Background-Even today, infective endocarditis (IE) remains a severe and potentially fatal disease demanding sophisticated diagnostic strategies for detection of the causative microorganisms. Despite the use of appropriate laboratory techniques, classic microbiological diagnostics are characterized by a high rate of negative results. Methods and Results-Broad-range polymerase chain reaction (PCR) targeting bacterial and fungal rDNA followed by direct sequencing was applied to excised heart valves (nϭ52) collected from 51 patients with suspected infectious endocarditis and from 16 patients without any signs of IE during an 18-month period. The sensitivity, specificity, and the positive and negative predictive values for the bacterial broad-range PCR were 41.2%, 100.0%, 100.0%, and 34.8%, respectively, compared with 7.8%, 93.7%, 80.0%, and 24.2% for culture and 11.8%, 100.0%, 100.0%, and 26.2% for Gram staining. Without exception, database analyses allowed identification up to the (sub)species level comprising streptococcal (nϭ13), staphylococcal (nϭ4), enterococcal (nϭ2), and other signature sequences such as Bartonella quintana and Nocardia paucivorans. Fungal ribosomal sequences were not amplified. All valve tissues of the reference group were negative for both PCR and conventional methods, except one sample that was contaminated by molds. Conclusions-Culture-independent molecular methods substantially improve the diagnostic outcome of microbiological examination of excised heart valves. Importantly, this was true not only for fastidious, slow-growing, and/or nonculturable microorganisms but also for easy-to-culture pathogens such as streptococci and staphylococci. Both patient management and empiric antibiotic therapy of IE are likely to benefit from improved knowledge of the spectrum of pathogens now causing IE.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of a Molecular Approach to Improve the Microbiological Diagnosis of Infective Heart Valve Endocarditis

et al. 2005

View full text Add to dashboard Cite

show abstract

“…There is a high prevalence of specific antibody (IgE) to Malassezia antigens in affected patients who respond to azole antifungals. 24,25 Here it is most often associated with intravenous lipid supplementation. 21 Confluent and reticulate papillomatosis 22 is a rare condition affecting the upper trunk where patients develop a linear network of scaly lesions.…”

Section: Other Conditionsmentioning

confidence: 99%

Malassezia, dandruff and seborrhoeic dermatitis: an overview

Hay

2011

British Journal of Dermatology

115

View full text Add to dashboard Cite

From their original description, fungi of the genus Malassezia (previously Pityrosporum) have been associated with dandruff and seborrhoeic dermatitis. The principle evidence on which this connection was based was that the organisms were present, often in high numbers, on the skin in these conditions and that both responded to treatment that inhibited or destroyed Malassezia yeasts. The availability of new tools such as genomic and proteomic analyses has begun to provide a new insight into the pathogenetic mechanisms involved. New evidence shows the production of specific phospholipases on affected skin sites in dandruff and signalling molecules such as malassezin in seborrhoeic dermatitis. It is still not clear why those individuals and skin sites, prone to either disease, are particularly associated with the presence of these marker molecules but these studies are providing clues to the different ways in which organisms, which are normally commensals, interact with human skin.

show abstract

“…The isolation of Malassezia furfur and M. sympodialis from catheter samples in ICU patients is signifi cant as they have been ascribed a role in fungemia in pediatric patients with parental lipid hyperalimentation [35][36][37] . Susceptibility tests for yeasts have not been standardized to date, nevertheless it is important to introduce changes in the current laboratory methodology in order to enable their isolation, avoiding underdiagnosis.…”

Section: Discussionmentioning

confidence: 99%

Fluconazole and Itraconazole Resistance of Yeasts Isolated from the Bloodstream and Catheters of Hospitalized Pediatric Patients

et al. 2006

View full text Add to dashboard Cite

Background: In critically ill children, Candida species and other yeasts appear as an important nosocomial pathogen. The emerging fungal pathogens are usually less susceptible to azole compounds, and the management of such infections could be problematic. Methods: 6,065 bloodstream cultures and 627 catheters from intensive care units and hospitalized oncology pediatric patients were studied. Antifungal susceptibility testing of isolates was performed according to the reference broth microdilution method describedby the National Committee for Clinical Laboratory Standards (M27-A). Results: We found a low activity of fluconazole (FCZ) and itraconazole (ITZ) against Candida glabrata, C. albicans, C. tropicalis and C. haemulonii. Resistant strains to FCZ and ITZ were detected. Conclusion: Results reveal the emergence of antifungal-resistant species and a change in the predominant role of C. albicans as a cause of candidemia in hospitalized children.

show abstract

Malassezia furfur-related colonization and infection of central venous catheters

Abstract: The incidence of Malassezia furfur-related colonization of central venous catheters appears to be low but not negligible, which warrants the use of specific culture techniques.

Cited by 27 publications

References 15 publications

Impact of a Molecular Approach to Improve the Microbiological Diagnosis of Infective Heart Valve Endocarditis

Impact of a Molecular Approach to Improve the Microbiological Diagnosis of Infective Heart Valve Endocarditis

Malassezia, dandruff and seborrhoeic dermatitis: an overview

Fluconazole and Itraconazole Resistance of Yeasts Isolated from the Bloodstream and Catheters of Hospitalized Pediatric Patients

Contact Info

Product

Resources

About