MALAT-1: Immunomodulatory lncRNA hampering the innate and the adaptive immune arms in triple negative breast cancer

Mekky, Radwa Y.; Ragab, Mai F.; Manie, Tamer M.; Attia, Abdelrahman A.; Youness, R.A.

doi:10.1016/j.tranon.2023.101653

Cited by 30 publications

(38 citation statements)

References 59 publications

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“…Long transcripts of RNA having more than 200 nucleotides, and not involved in protein translation are regarded as lncRNAs (Refs 16, 18, 154). LncRNAs play a significant role in the occurrence and development of cancer and thus, regulate the expression of cytokines such as IL-10 and IFN- γ as reported in a study by Tang et al .…”

Section: The Tumour Microenvironmentmentioning

confidence: 99%

“…The multifaceted dynamic milieu of cellular components along with non-cellular compartments portrays what is now known as the tumour microenvironment (TME) (Refs 6,13,14). Such a microenvironment could control the aggressiveness, rate of growth and metastatic potential of the tumour (Refs [15][16][17][18] (Refs 43,44). Interestingly, these immune cells drive the production of soluble components that include cytokines, chemokines, growth factors and extra-cellular remodelling enzymes (Refs 27,28).…”

Section: The Tumour Microenvironmentmentioning

confidence: 99%

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Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology

Elemam,

Mekky,

Rashid

et al. 2024

Expert Rev. Mol. Med.

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The host immune system status remains an unresolved mystery among several malignancies. An immune-compromised state or smart immune-surveillance tactics orchestrated by cancer cells are the primary cause of cancer invasion and metastasis. Taking a closer look at the tumour-immune microenvironment, a complex network and crosstalk between infiltrating immune cells and cancer cells mediated by cytokines, chemokines, exosomal mediators and shed ligands are present. Cytokines such as interleukins can influence all components of the tumour microenvironment (TME), consequently promoting or suppressing tumour invasion based on their secreting source. Interleukin-10 (IL-10) is an interlocked cytokine that has been associated with several types of malignancies and proved to have paradoxical effects. IL-10 has multiple functions on cellular and non-cellular components within the TME. In this review, the authors shed the light on the regulatory role of IL-10 in the TME of several malignant contexts. Moreover, detailed epigenomic and pharmacogenomic approaches for the regulation of IL-10 were presented and discussed.

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Section: The Tumour Microenvironmentmentioning

confidence: 99%

Section: The Tumour Microenvironmentmentioning

confidence: 99%

Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology

Elemam,

Mekky,

Rashid

et al. 2024

Expert Rev. Mol. Med.

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“…Various immunological elements are found upon cellular examination of a typical TME, indicating an immune battle against the tumor. ,− The appearance of multiple cytokines, macrophages, neutrophils, and tumor-infiltrating lymphocytes (TILs), among others, signify an attempt of the host immune system to eradicate the tumor. ,− …”

Section: Phototriggered Liposomes In Cancer Chemotherapy and Immunoth...mentioning

confidence: 99%

A Snapshot of Photoresponsive Liposomes in Cancer Chemotherapy and Immunotherapy: Opportunities and Challenges

Youness,

Mohamed,

Efthimiadou

et al. 2023

ACS Omega

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To provide precise medical regimens, photonics technologies have been involved in the field of nanomedicine. Phototriggered liposomes have been cast as promising nanosystems that achieve controlled release of payloads in several pathological conditions such as cancer, autoimmune, and infectious diseases. In contrast to the conventional liposomes, this photoresponsive element greatly improves therapeutic efficacy and reduces the adverse effects of gene/drug therapy during treatment. Recently, cancer immunotherpay has been one of the hot topics in the field of oncology due to the great success and therapeutic benefits that were well-recognized by the patients. However, several side effects have been encountered due to the unmonitored augmentation of the immune system. This Review highlights the most recent advancements in the development of photoresponsive liposome nanosystems in the field of oncology, with a specific emphasis on challenges and opportunities in the field of cancer immunotherapy.

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“…Many of the genes that include ncRNAs are evolutionarily conserved, much like protein‐coding genes, and have been connected to a variety of biological processes that impact development, differentiation, and several aspects of cellular physiology (Youness & Gad, 2019). It is becoming obvious that abnormal ncRNAs expression is frequently seen in several cancers (Abdallah et al, 2022; Awad et al, 2021; El Din et al, 2021; El Kilany et al, 2021; Fahmy, Dawoud, et al, 2022; Mekky et al, 2023; Nafea et al, 2020; Ramzy et al, 2022; Shaalan et al, 2018; Youness, Rahmoon, et al, 2016; Youness et al, 2018, 2019, 2021, 2022; ZeinElAbdeen et al, 2022), indicating that ncRNAs are important participants in human carcinogenesis (Abdel‐Latif et al, 2022; Ahmed Youness et al, 2020; ElKhouly et al, 2020; Fahmy, Dawoud, et al, 2022; Mekky et al, 2019; Nafea et al, 2021; Soliman et al, 2022; Youssef et al, 2022; ZeinElAbdeen et al, 2022). Recent evidence suggests that these evolutionarily conserved ncRNAs, notably long noncoding RNAs (lncRNAs), PIWI‐interacting RNAs (piRNAs), and circular RNAs (circRNAs), play a significant role in a variety of physiological and pathological processes (Dawoud et al, 2023; Selem et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…The serine/arginine (SR) proteins and other splicing factors are controlled by this lncRNA interactions with them (Tripathi et al, 2010). It is overexpressed in numerous human carcinomas, including colorectal cancer, non‐small‐cell lung cancer, endometrial stromal sarcoma (ESS), breast cancer, and HCC, and is strongly expressed in the brain (Abdel‐Latif et al, 2022; Fahmy, Dawoud, et al, 2022; Mekky et al, 2023; Zhou et al, 2022). Both HCC cell lines and clinical tissue samples had higher levels of MALAT‐1.…”

Section: Introductionmentioning

confidence: 99%

Decoding hepatocarcinogenesis from a noncoding RNAs perspective

El-Aziz

Dawoud

Kiriacos

et al. 2023

Journal Cellular Physiology

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Being a leading lethal malignancy worldwide, the pathophysiology of hepatocellular carcinoma (HCC) has gained a lot of interest. Yet, underlying mechanistic basis of the liver tumorigenesis is poorly understood. The role of some coding genes and their respective translated proteins, then later on, some noncoding RNAs (ncRNAs) such as microRNAs have been extensively studied in context of HCC pathophysiology; however, the implication of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in HCC is indeed less investigated. As a subclass of the ncRNAs which has been elusive for long time ago, lncRNAs was found to be involved in plentiful cellular functions such as DNA, RNA, and proteins regulation. Hence, it is undisputed that lncRNAs dysregulation profoundly contributes to HCC via diverse etiologies. Accordingly, lncRNAs represent a hot research topic that requires prime focus in HCC. In this review, the authors discuss breakthrough discoveries involving lncRNAs and circRNAs dysregulation that have contributed to the contemporary concepts of HCC pathophysiology and how these concepts could be leveraged as potential novel diagnostic and prognostic HCC biomarkers. Further, this review article sheds light on future trends, thereby discussing the pathological roles of lncRNAs and circRNAs in HCC proliferation, migration, and epithelial‐to‐mesenchymal transition. Along this line of reasoning, future recommendations of how these targets could be exploited to achieve effective HCC‐related drug development is highlighted.

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MALAT-1: Immunomodulatory lncRNA hampering the innate and the adaptive immune arms in triple negative breast cancer

Cited by 30 publications

References 59 publications

Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology

Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology

A Snapshot of Photoresponsive Liposomes in Cancer Chemotherapy and Immunotherapy: Opportunities and Challenges

Decoding hepatocarcinogenesis from a noncoding RNAs perspective

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