2019
DOI: 10.7150/ijms.30097
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MALAT1 as a Diagnostic and Therapeutic Target in Diabetes-Related Complications: A Promising Long-Noncoding RNA

Abstract: Diabetes mellitus is a global issue with increasing incidence rate worldwide. In an uncontrolled case, it can advance to various organ-related complications leading to an increase in morbidity and mortality. Long non-coding RNA (lncRNA) Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) appears to be a fairly novel lncRNA that is relevant to diabetes and its role in diabetic-related diseases initiation and progression have long been a subject of attention to many scholars. The expression of MALAT1… Show more

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Cited by 81 publications
(69 citation statements)
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“…MALAT1 and inflammation cytokines including TNF‐α, IL‐1β, and IL‐6 were considerably up‐regulated in diabetes mellitus rats or in the diabetic myocardium. Inhibition of MALAT1 improves the cardiac function and inflammation cytokine concentration . In addition, MALAT1 was also found to enhance palmitic acid induced apoptosis of cardiomyocytes by sponging miR‐26a to activate TLR4/NF‐κB‐mediated inflammatory response and up‐regulate the expression of HMGB1 .…”
Section: Malat1 and Cardiac Dysfunctionmentioning
confidence: 99%
See 1 more Smart Citation
“…MALAT1 and inflammation cytokines including TNF‐α, IL‐1β, and IL‐6 were considerably up‐regulated in diabetes mellitus rats or in the diabetic myocardium. Inhibition of MALAT1 improves the cardiac function and inflammation cytokine concentration . In addition, MALAT1 was also found to enhance palmitic acid induced apoptosis of cardiomyocytes by sponging miR‐26a to activate TLR4/NF‐κB‐mediated inflammatory response and up‐regulate the expression of HMGB1 .…”
Section: Malat1 and Cardiac Dysfunctionmentioning
confidence: 99%
“…Inhibition of MALAT1 improves the cardiac function and inflammation cytokine concentration. 72,73 In addition, MALAT1 was also found to enhance palmitic acid induced apoptosis of cardiomyocytes by sponging miR-26a to activate TLR4/NF-κB-mediated inflammatory response and up-regulate the expression of HMGB1. 74 However, MALAT1 was also found to induce antiviral immunity in patients with coxsackievirus B3 (CVB3) cardiomyopathy or CVB-infected rats.…”
Section: Myocardial Inflammatory Injuriesmentioning
confidence: 99%
“…lncRNAs are generally considered to be important regulators of adipogenesis and adipocyte metabolism [13][14][15][16][17]. lncRNAs also play a role in the pathogenesis of T2DM and T2DM-related complications [18][19][20][21][22][23][24]. Competitive endogenous RNA (ceRNA) was first proposed by Salmena et al [25] and was defined as a class of noncoding RNAs that bind to miRNA.…”
Section: Introductionmentioning
confidence: 99%
“…MALAT1 is an important lncRNA that has been widely investigated [18,[54][55][56][57]. Recent studies had reported that the MALAT1 regulates the production of inflammatory cytokines [56] and was increased in a LPS-induced acute lung injury model to regulate the release of IL-1β, IL-6, and TNF-α [58]. Silencing of MALAT1 inhibited the proinflammatory responses by enhancing miR-146a levels in macrophages and epithelial cells [58].…”
Section: Lncrnas Regulate Macrophage Infiltration Polarization Andmentioning
confidence: 99%