2023
DOI: 10.1186/s12885-023-10867-6
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MALAT1 functions as a transcriptional promoter of MALAT1::GLI1 fusion for truncated GLI1 protein expression in cancer

Abstract: Background The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a cancer biomarker. Furthermore, fusion of the MALAT1 gene with glioma-associated oncogene 1 (GLI1) is a diagnostic marker of plexiform fibromyxoma and gastroblastoma; however, the function of this fusion gene remains unexplored. Method In this study, we elucidate the structure and function of the MALAT1::GLI1 fusion gene. To this end, we determine… Show more

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Cited by 4 publications
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“…Additionally, GLI1 gene translocation was reported in 24% of cases, and GLI1 polysomy was reported in 8% of cases among a total of 25 cases subjected to GLI1 genetic analysis [17,18]. This translocation results in the overexpression of GLI1 protein, a phenomenon also observed in various neoplasms, activating the hedgehog signaling pathway, which is crucial in gastrointestinal development [19][20][21][22].…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, GLI1 gene translocation was reported in 24% of cases, and GLI1 polysomy was reported in 8% of cases among a total of 25 cases subjected to GLI1 genetic analysis [17,18]. This translocation results in the overexpression of GLI1 protein, a phenomenon also observed in various neoplasms, activating the hedgehog signaling pathway, which is crucial in gastrointestinal development [19][20][21][22].…”
Section: Introductionmentioning
confidence: 99%