Malathion, an organophosphate insecticide, provokes metabolic, histopathologic and molecular disorders in liver and kidney in prepubertal male mice

Selmi, Slimen; Rtibi, Kaïs; Grami, Dhekra; Sebaï, Hichem; Marzouki, Lamjed

doi:10.1016/j.toxrep.2017.12.021

Cited by 94 publications

(76 citation statements)

References 54 publications

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“…As a result, the amount of these parameters in the blood is directly associated with the amount of liver injured. The results reported in this study are in agreement with previous studies, which indicated that exposure to malathion and other pesticides induced severe adverse biochemical alterations that affect the functional and structural integrity of the liver tissues in experimental animals (Al-Attar, 2010; Al-Attar, 2015; Kasmi et al, 2018;Selmi et al, 2018;Aboubakr et al, 2019;Jalili et al, 2019;Khalifa and Alkhalf, 2019).…”

Section: Discussionsupporting

confidence: 92%

“…The present results revealed that the exposure to malathion led to the decline of serum total protein level, while the levels of serum glucose, triglycerides and cholesterol were significantly enhanced. These results are consistent with previous studies which indicated that exposure to malathion and other pesticides induced severe disturbance of proteins, carbohydrates and lipids metabolism (Al-Attar, 2015;El-Beih et al, 2017;Selmi et al, 2018;Khalifa and Alkhalf, 2019). The decline of serum total protein indicates the presence of para proteins or decreased antibody production.…”

Section: Discussionsupporting

confidence: 92%

“…The present study showed that malathion induced oxidative stress which confirmed by the increase of serum MDA level and the decrease of CAT level. These findings are generally in agreement with previous experimental investigations on animals exposed to malathion and other pesticides (Avci et al, 2018;Selmi et al, 2018;Uchendu et al, 2018;Aboubakr et al, 2019;Jalili et al, 2019;Khalifa Alkhalf, 2019). MDA is an end product of lipid peroxidation, and therefore increased concentrations indicate an increase in reactive oxygen species (ROS) concentration and resulting oxidative damage.…”

Section: Discussionsupporting

confidence: 91%

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The Potential Protective Effect of Sesame Oil and Canola Oil on Rats Exposed to Malathion

2019

Curr. Sci. Int.

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Currently, the environmental pollution is occurring on a vast and unprecedented scale around the globe. Pesticides are the largest group of chemicals that are used widely in modern agricultural practices. Pesticides have been associated with health and environmental issues, and the agricultural use of certain pesticides has been abandoned. Pesticides are basically poisons and therefore toxic to living organism at particular dose. Medicinal plants have a promising future because there are about half million plants around the world, and most of them their medical activities have not investigate yet, and their medical activities could be decisive in the treatment of present or future studies. Natural products from plants, animals and minerals are the basis for treating human diseases. The purpose of the present study was to evaluate the effects of sesame oil and canola oil on male rats exposed to malathion. Experimental rats were divided into six groups. Group 1 was served as normal control. Rats of group 2 were exposed to malathion. Rats of group 3 were treated with sesame oil and malathion. Rats of group 4 were subjected to canola oil and malathion. Rats of group 5 and 6 were supplemented with sesame oil and canola oil respectively. After the end of experimental duration (8 weeks), rats of group 2 showed significant reduction of body weight gain, and severe hematological and biochemical alterations including significant decreases of RBC, HB, Hct, WBC, total protein, glucose and CAT, and increases of ALT, AST, ALP, total bilirubin, triglycerides, cholesterol, creatinine, uric acid and MDA values. Administration of sesame oil and canola oil improved the observed hematological and biochemical alterations induced by malathion intoxication. These new findings indicate that sesame oil and canola oil represent protective roles on hematological and biochemical disturbances induced by malathion toxicity due to their antioxidant activities.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

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The Potential Protective Effect of Sesame Oil and Canola Oil on Rats Exposed to Malathion

2019

Curr. Sci. Int.

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“…[12] Kidney is the major organ for metabolism and disposal of malathion through urine. [13] The primary or secondary disposal of some drugs and toxins during a progressive trend usually leads to chronic renal disorders. [14] Resveratrol is a plant-derived polyphenolic phytoalexin that is produced by stilbene synthase enzyme in response to environmental stresses such as climate change, exposure to heavy metals, and infectious agents.…”

mentioning

confidence: 99%

Resveratrol attenuates malathion-induced renal damage by declining oxidative stress in rats

Jalili

Roshankhah

Moradi

et al. 2018

Int J Pharma Investig

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Extensive and uncontrolled use of pesticides and insecticides has long been known as a major environmental problem, to which researchers have been trying to discover an appropriate substitute. [1] Organophosphorus compounds are a sanitary problem around the world that has been reported as the third leading cause of toxicity-induced death. [2] Organophosphorus insecticides have phosphor in their structure and are one of the derivatives of phosphoric acid. [3] The most frequently used organophosphorus compounds include metasystox, malathion, xanthion, and Background: Malathion is the most organophosphates which are capable to produce free radicals and induce disturbance in body antioxidant. Resveratrol is an herbal polyphenol and it has been beneficial antioxidant effects during short-term administration. This study was designed to evaluate the effects of resveratrol against damage induced by malathion to the kidneys of rats. Materials and Methods: Forty-eight Wistar rats divided randomly into eight groups (n = 6): sham (saline) and malathion control treated groups (27 mg/kg); resveratrol groups (2, 8, and 20 mg/kg); and resveratrol + malathion-treated groups (2, 8, and 20 mg/kg). Treatments were administered intraperitoneally and gavage daily for 45 days. Parameters related to the function and the histology of the kidneys were evaluated and statistically analyzed from kidney and blood serum samples in respect of the groups. Results: Malathion administration increased significantly Bowman's space, qualitative histopathology indices, kidney malondialdehyde (MDA) level, blood urea nitrogen (BUN), creatinine, and nitrite oxide levels and decreased significantly total antioxidant capacity (TAC) level and diameter and number of renal corpuscles compared to the Sham group (P < 0.001). The resveratrol and resveratrol + malathion treatments in a dose-dependent manner reduced significantly Bowman's space, qualitative histopathology indices, kidney MDA level, BUN, creatinine, and nitrite oxide levels and increased significantly TAC level and diameter and number of renal corpuscles compared to the malathion control group (P < 0.001). Conclusion: It seems that resveratrol administration in a dose-dependent manner improved kidney injury induced by malathion in rats.

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“…The unregulated use of OPPs and their application over large agricultural and urban areas, has caused severe environmental pollution and potential health hazards (Sodhi et al, 2008). Particularly, malathion [O,Odimethyl-S-(1,2-dicarcethoxyethyl) phosphorodithioate] is a widely used OPP habitually used to eradicate ectoparasites, household insects, to conserve stored grain and to eliminate disease-inducing arthropods (Selmi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of selenium on malathion-induced testicular toxicity in mice

Ibrahim

Wani

Khalifa

et al. 2019

IJAR

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The aim of this study was to investigate the possible protective effect of the antioxidant sodium selenite (0.1 mg/kg/day) via gavage once a day for 30 days for the first time in a model of malathion (27 mg/kg/day) via gavage once a day for 30 days induced testicular toxicity in mice. Results of this study revealed that concomitant administration of selenium has prevented the decrease in mean final and relative body weight as well as testicular and relative testicular weight as compared to malathion group. Concomitant selenium administration has also decreased malondialdehyde contents and increased serum levels of follicle stimulating hormone, luteinizing hormone, testosterone, acetylcholinesterase and testicular levels and activities of glutathione, glutathione peroxidase, catalase, superoxide dismutase and improved the testicular histopathological features as compared to malathion group.

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Malathion, an organophosphate insecticide, provokes metabolic, histopathologic and molecular disorders in liver and kidney in prepubertal male mice

Abstract: Graphical abstract

Cited by 94 publications

References 54 publications

The Potential Protective Effect of Sesame Oil and Canola Oil on Rats Exposed to Malathion

The Potential Protective Effect of Sesame Oil and Canola Oil on Rats Exposed to Malathion

Resveratrol attenuates malathion-induced renal damage by declining oxidative stress in rats

Protective effects of selenium on malathion-induced testicular toxicity in mice

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