Male Antifertility Compounds: U-5897 as a Rat Chemosterilant

Abstract

Summary. U-5897 (3-chloro-1,2-propanediol

Male Antifertility Compounds: Biological Properties of U-5897 and U-15,646

“…Approximately five times the MED of either compound will, however, produce a lesion in the caput epididymidis of the rat. This prevents spermatozoa from entering the epididymis and proper removal of testicular fluids causing testicular swelling and some alteration in spermatogenesis (Ericsson, 1970). However, epididymal lesions were not induced in guinea-pigs even at doses which ultimately caused death.…”

“…In the rabbit, spermatozoa from the caput epididymidis are incapable of fertility (Bedford, 1966(Bedford, , 1967Orgebin-Crist, 1967 (Mason & Young, 1967) and is perhaps more vulnerable to these drugs because of the sluggishness of blood flow (see Ericsson (1970) for a more complete review of this phenomenon). The resultant conditions yield spermatozoa incapable of performing their normal function of fertilizing ova, which is supported by the absence of spermatozoa on recovered uncleaved ova.…”

Chemically Induced Sperm Retention Cysts in the Rat

“…It frequently induces pathological changes in the epididymis, culminating in cyst formation in this duct on one or both sides (Cooper & Jackson, 1970). Ericsson (1970) found that a-chlorhydrin (U-5897) caused cysts in the rat, specifically in the ductuli efferentes and initial part of the caput epididymidis, which led to permanent sterility. Recently, Ericsson (1971) (Clermont & Flannery, 1970 (Cooper & Jackson, 1970).…”

The control of male fertility by 6-chloro-6-deoxysugars

“…Fifty percent of rats given a single large dose of 6 CDG (250 mg/kg) developed spermatocoeles which were identical in appearance to those produced by «-chlorohydrin (Ericsson, 1970 ;Hoffer et al, 1973 …”