Male breast cancer: A case of apocrine carcinoma with psammoma bodies

Bryant, James

doi:10.1016/s0046-8177(81)80178-5

Cited by 13 publications

(6 citation statements)

References 8 publications

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“…' Histologically, apocrine breast cancers are composed of large eosinophilic cells with abundant granular cytoplasm, prominent nucleoli, and apical ough apocrine carcinomas are usually classified as ductal neoplasms, apocrine differentiation may be associated with lobular, medullary, or adenoid cystic breast cancers.2'8,19,21*22*25929 The growth pattern is most frequently intraductal and/or papillary, but the tumors may be gland-forming, cystic, cribriform, solid, or diffusely infiltrating.4,7*9918*25 Apical snouts, a reflection of merocrine secretion, may be noted along papillary stalks or within glandular lumina formed by nosis. l, 7,8,9,16,[18][19][20][21][22][23] snouts.l,4,8,9,1 1,13,14,19,20,[23][24][25][26][27][28] Alth Diagnostic Cytopathology, Vol5. No 3 tumor ce11s.…”

Section: Discussionmentioning

confidence: 99%

The significance of atypical apocrine cells in fine‐needle aspirates of the breast

Johnson

Kini

1989

Diagnostic Cytopathology

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Apocrine metaplastic cells are frequently present in fine-needle aspirates (FNAs) of breast lesions, especially fibrocystic disease. Occasionally, apocrine cells may be atypical and present diagnostic difficulties. The morphologic features of six breast FNAs that contained atypical apocrine cells in breast aspirates. In the six abnormal cases, the large, pleomorphic, atypical apocrine cells were the predominant cell type and occurred singly and in syncytial tissue fragments. The cells had large, eccentric, vesicular nuclei and usually multiple macronucleoli. The histologic diagnoses in the cases were apocrine carcinoma (five cases) and atypical apocrine metaplasia (one case). In comparison, benign apocrine cells are relatively small and uniform and arranged in cohesive, orderly sheets. It is concluded that, in breast FNAs, the predominance of atypical apocrine cells, occurring singly and in syncytia, should raise the suspicion of carcinoma.

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Section: Discussionmentioning

confidence: 99%

The significance of atypical apocrine cells in fine‐needle aspirates of the breast

Johnson

Kini

1989

Diagnostic Cytopathology

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“…To the best of our knowledge, only four cases of pure mucinous carcinoma with psammomatous calcifications have been reported so far, 5,8–10 and none has described psammoma bodies in such abundance as in our case. In addition to the rare occurrence of psammoma bodies in pure mucinous carcinoma, these calcifications have also been reported in other lesions of breast such as invasive apocrine carcinoma (in a male breast) 11 and apocrine papilloma 12 …”

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confidence: 87%

Pure mucinous carcinoma of the breast with extensive psammomatous calcification

Rao

Lyons

2008

Histopathology

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13. McIntosh GG, Lodge AJ, Watson P et al. NCL-CD10-270: a new monoclonal antibody recognising CD10 in paraffin-embedded tissue. Am. J. Pathol. 1999; 154; 77-82. 14. Kesse-Adu R, Shousha S. Myoepithelial markers are expressed in at least 29% of oestrogen receptor negative breast carcinoma. Mod. Pathol. 2004; 17; 646-652. 15. Tse GMK, Tsang AKH, Putti TC. et al. Stromal CD10 expression in mammary fibroadenoma and phyllodes tumours. J. Clin. Pathol. 2005; 58; 185-189. 16. Makretsov NA, Hayes M, Carter BA, Dabiri S, Gilks CB, Huntsman DG. Stromal CD10 expression in invasive breast carcinoma correlates with poor prognosis, estrogen receptor negativity, and high grade. Mod. Pathol. 2007; 20; 84-89. 17. Khanafshar E, Phillipson J, Schammel DP, Minobe L, Cymerman J, Weidner N. Inflammatory myofibroblastic tumor of the breast. Ann Diagn. Pathol. 2005; 9; 123-129. 18. Magro G, Caltabiano R, Di Cataldo A, Puzzo L. CD10 is expressed by mammary myofibroblastoma and spindle cell lipoma of soft tissue: an additional evidence of their histogenetic linking. Virchows Arch. 2007; 450; 727-728. 19. Leibl S, Moinfar F. Mammary NOS-type sarcoma with CD10 expression. A rare entity with features of myoepithelial differentiation. Am. J. Surg. Pathol. 2006; 30; 450-456.

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“…Apocrine carcinoma is a rare variant of breast carcinoma that occurs in advanced age, the peak incidence being the sixth and seventh decades of life [2]. Apocrine carcinoma occurs in both females and males and manifests as a solid or cystic mass ranging from 0.5 to 5 cm in diameter [9]. Mammographic presentation did not present differences from those of ductal carcinomas [31].…”

Section: Apocrine Dcis-apocrine Carcinomamentioning

confidence: 99%

The enigmatic nature of apocrine breast lesions

et al. 2006

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Epithelial cells of fetal breast glandular structures, at the third trimester of pregnancy (28 weeks), produce GCDFP-15, in the absence of specific apocrine morphology. Apocrine epithelium of the breast may be a normal process of differentiation rather than a result of metaplasia, and it has been demonstrated that it is estrogen-receptor, progesterone-receptor and bcl-2 negative, but androgen-receptor (AR) positive. The significance of AR expression in apocrine epithelium is uncertain. Apocrine epithelium is seen in a wide spectrum of breast entities, ranging from benign lesions to invasive carcinoma. Breast cancer accounts 32% of all cancer cases among women and is the most common type of cancer in women. Little is known about breast carcinogenesis. Widely, it is accepted that breast cancer, like most other type of cancer, is being developed through the accumulation of genetic aberrations. Apocrine epithelium may reflect instability of the breast epithelium, creating an environment favouring further oncogenic alterations. In the last decade, several lines of evidence support the idea that some breast benign epithelial apocrine lesions are clonal lesions and may be considered as truly pre-malignant or precursors of breast carcinoma. Apocrine changes in many cases do not present any diagnostic difficulty; on the other hand, apocrine proliferations with cytologic atypia can be particularly difficult and challenging. The purpose of this study is to collect and highlight the areas of consensus in the literature as well as the controversial areas concerning the apocrine epithelium of the breast.

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Male breast cancer: A case of apocrine carcinoma with psammoma bodies

Cited by 13 publications

References 8 publications

The significance of atypical apocrine cells in fine‐needle aspirates of the breast

The significance of atypical apocrine cells in fine‐needle aspirates of the breast

Pure mucinous carcinoma of the breast with extensive psammomatous calcification

The enigmatic nature of apocrine breast lesions

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