Male breast cancer: clinicopathological, immunohistochemical and radiological study

Abstract

Objective: To evaluate the pathological and radiological features, immunohistochemical profile and treatment methods of primary male breast carcinoma cases diagnosed at our center. Material and Method: The pathology archive between 2006 and 2019 was reviewed and the data of 27 male patients diagnosed as primary breast cancer were retrospectively evaluated. Results: The age of the patients ranged between 40-86 years. The left breast was involved in 17 patients. The mean tumor diameter was 2.35 ± 1.09 cm. Of the 27 cases, 8 were dead and 19 were alive. The mean follow-up duration was 37.45 ± 24.84 months. The mean estimated life expectancy was 65±14.7 months. The most common complaint was a swelling in the breast. The time interval between the onset of complaints and admittance to hospital ranged from three months to two years. The most common histopathological diagnosis was invasive carcinoma-no special type. The most common surgical procedure was mastectomy with lymph node dissection. Nine patients had metastatic lymph nodes. In terms of the hormone profiles, 24 were Estrogen receptor positive, 21 were Progesterone receptor positive and six were Her2/neu positive. Three patients had triple-negative tumors. Conclusion: Male breast carcinoma is a rare disease but its frequency has been increasing recently. As breast cancer is more commonly attributed to women, the diagnosis is usually delayed until later stages in males. Public awareness should therefore be increased and breast cancer should be considered in the differential diagnosis especially in the presence of breast swelling and complaints related to the breast skin so that the appropriate biopsy can be obtained without delay.

Profile of Male Breast Cancer in Makkah Region of Saudi Arabia: A 4-Year Retrospective Analysis of Radiology and Histopathology

“…Our study attempted to present the radiological and clinicopathological characteristics of MBC patients in the western region of KSA. According to imaging features of the 20 patients who had an ultrasound, 16 (80%) lesions were presented as hypoechoic solid masses with irregular margins [ 74 ]; in our cases, also, majority of cases have ill-defined margins and hypoechoic solid mass, respectively.…”

“…We have found only 1 patient who had a well-defined mass, and 5 patients had ill-defined mass out of total 17 screened cases that is closely similar to the data reported by Doyle et al, where they found that out of 13 patients who underwent mammography, 6 of them had an ill-defined breast mass and 2 had a well-defined breast mass visualized [ 73 ]. The time interval between the onset of complaints and admittance to hospital ranged from three months to two years [ 74 ]. The median duration of the evolution of the MBC symptoms and signs was 9 months [ 75 , 76 ].…”