Male but not female mice with severe osteogenesis imperfecta are partially protected from high-fat diet-induced obesity

Tauer, Josephine T.; Boraschi-Diaz, Iris; Rifai, Omar Al; Rauch, Frank; Ferron, Mathieu; Komarova, Svetlana V.

doi:10.1016/j.ymgme.2021.03.014

Cited by 3 publications

(7 citation statements)

References 78 publications

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“…Experimental design and treatment are described here [1] . In brief, the Col1a1 Jrt/+ mouse on FVB background was used as mouse model for dominant moderate-to-severe Osteogenesis imperfecta (OI) [ 4 , 5 ].…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

“…Diets were purchased from Envigo (Huntingdon, UK) and were supplemented with vitamin mix containing vitamin D 3 and vitamin K 1 . Detailed diet composition can be found in the Supplement of the related research article [1] . Diets were stored at 4 °C before usage.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

“…GTT was performed as described before [1] . Food was withdrawn for 5 h for 4-week-old mice, or for 16 h for older mice, prior to GTT.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

“…Interpretation of the data and further in-depth analysis can be found here [1] . All raw individual mouse outcomes of long-term diet experiments can be found in the excel file available by the Mendeley database [2] .…”

Section: Data Descriptionmentioning

confidence: 99%

“…4 depicts selected femoral structural and mechanical properties in male and female WT and OI mice at the end of the study. Further, femoral structural and mechanical parameters can be found here [1] and in the Mendeley database.

Fig.…”

Section: Data Descriptionmentioning

confidence: 99%

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Data on body mass, glucose tolerance and bone phenotype of mice with osteogenesis imperfecta on long-term low-fat and high-fat diets

2022

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Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

“…GTT was performed as described before [1] . Food was withdrawn for 5 h for 4-week-old mice, or for 16 h for older mice, prior to GTT.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Section: Data Descriptionmentioning

confidence: 99%

Fig.…”

Section: Data Descriptionmentioning

confidence: 99%

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Data on body mass, glucose tolerance and bone phenotype of mice with osteogenesis imperfecta on long-term low-fat and high-fat diets

2022

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Differential bone metabolism and protein expression in mice fed a high-fat diet versus Daurian ground squirrels following natural pre-hibernation fattening

Gao

Shen

Niu

et al. 2022

J. Zhejiang Univ. Sci. B

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Long-Term Pterostilbene Supplementation of a High-Fat Diet Increases Adiponectin Expression in the Subcutaneous White Adipose Tissue

et al. 2022

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Pterostilbene (Pt) is a natural phenol found in blueberries and grapes; it shows remarkable biomedical activities similar to those of resveratrol, but its higher bioavailability is a major advantage for possible biomedical applications. Our group has recently demonstrated that long-term (30 weeks) administration of Pt to mice maintained on a high-fat diet counters weight gain and promotes browning of subcutaneous white adipose tissue (sWAT). By Real-time quantitative PCR and Western Blot analysis of the sWAT and visceral white adipose tissue (vWAT) from the same mice used in the previous study, we show here that Pt induced a long-term increase of Adiponectin, Interleukin 10 and of M2 macrophage marker Cd206. The effects were observed in sWAT, while no significant changes were detected in vWAT. The process taking place seems to mimic that occurring in sWAT during cold-induced browning. Analysis of a few pro-inflammatory cytokines (Interleukin 6, Tumor necrosis factor α) and of the NFkB pathway did not reveal marked effects of Pt supplementation. In summary, the mechanisms and processes through which Pt acts in adipose tissue appear to closely mimic those set in motion by cold-induced browning, and point to a possible impact of experimental conditions in the final output of a nutraceutical intervention.

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Male but not female mice with severe osteogenesis imperfecta are partially protected from high-fat diet-induced obesity

Cited by 3 publications

References 78 publications

Data on body mass, glucose tolerance and bone phenotype of mice with osteogenesis imperfecta on long-term low-fat and high-fat diets

Data on body mass, glucose tolerance and bone phenotype of mice with osteogenesis imperfecta on long-term low-fat and high-fat diets

Differential bone metabolism and protein expression in mice fed a high-fat diet versus Daurian ground squirrels following natural pre-hibernation fattening

Long-Term Pterostilbene Supplementation of a High-Fat Diet Increases Adiponectin Expression in the Subcutaneous White Adipose Tissue

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