Male contraception: What do women think?

Richard, Claire; Pourchasse, M.; Freton, L.; Esvan, Maxime; Ravel, Célia; Peyronnet, B.; Mathiéu, Romain; Chhor, S.

doi:10.1016/j.purol.2021.11.003

Cited by 3 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The literature has consistently reported meaningful hypothetical male and female interest in male contraceptive methods as well as realized interest and acceptability of methods being tested in a clinical setting ( Heinemann et al, 2005 ; Cartwright et al, 2020 ; Nguyen et al, 2020 , 2021b ; Richard et al, 2022 ). Broadly, although there are differences among culture, geography, form of contraception, and other delineators, each finding reports that a substantial portion of men remains interested in a new and effective male contraceptive option ( Glasier, 2010 ; Nguyen et al, 2021a ).…”

Section: How Do Women and Men View A Potential Male Contraceptive?mentioning

confidence: 99%

Nonhormonal Male Contraceptive Development—Strategies for Progress

Nickels,

Yan

2023

Pharmacol Rev

View full text Add to dashboard Cite

Despite the widely demonstrated public health benefits of contraception, limited contraceptive options are available for men, placing both the contraceptive burden and opportunity solely on women. This review outlines the need for an increased focus on male contraceptive development and highlights several related topics, including the perspectives of women and men on male contraceptives, historical challenges, and reasons behind the persistent delays in male contraceptive development. It also discusses the importance of serendipitous observations in drug discovery and the limitations of depleting sperm or spermatogenic cells as a contraceptive approach. It further provides an overview of ongoing research and development on novel methods, with a goal to offer insights into the multifaceted aspects of nonhormonal male contraceptive development, addressing its implications for the health of men and women. Significance Statement Despite well over half a century of effort in developing male contraceptives, there are no approved male contraceptive drugs on the market. This review aims to present strategies for progress in nonhormonal male contraception based on lessons learned from history, with the hope of expediting development and bringing a male contraceptive drug closer to reality.

show abstract

Section: How Do Women and Men View A Potential Male Contraceptive?mentioning

confidence: 99%

Nonhormonal Male Contraceptive Development—Strategies for Progress

Nickels,

Yan

2023

Pharmacol Rev

View full text Add to dashboard Cite

show abstract

Synthetic androgens for male contraception

Page

2024

Contraception

View full text Add to dashboard Cite

Testosterone and male contraception

Thirumalai,

Page

2024

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

View full text Add to dashboard Cite

Purpose of review Rates of unintended pregnancy have remained relatively stagnant for many years, despite a broad array of female contraceptive options. Recent restrictions on access to abortion in some countries have increased the urgency for expanding contraceptive options. Increasing data suggest men are keen to utilize novel reversible male contraceptives. Recent findings Despite decades of clinical research in male contraception, no reversible hormonal product currently exists. Nestorone/testosterone, among other novel androgens, shows promise to finally move to pivotal Phase 3 studies and introduction to the marketplace. Summary Hormonal male contraception utilizes androgens or androgen-progestin combinations to exploit negative feedback that regulates the hypothalamic-pituitary-testicular axis. By suppressing release of gonadotropins, these agents markedly decrease endogenous testosterone production, lower intratesticular testosterone and suppress spermatogenesis. The addition of a progestin enhances the degree and speed of sperm suppression. The androgen component preserves a state of symptomatic eugonadism in the male. There is growing demand and acceptance of male contraceptive options in various forms. As these formulations progress through stages of drug development, regulatory oversight and communication with developers around safety and efficacy standards and garnering industry support for advancing the production of male contraceptives will be imperative.

show abstract

Male contraception: What do women think?

Cited by 3 publications

References 17 publications

Nonhormonal Male Contraceptive Development—Strategies for Progress

Nonhormonal Male Contraceptive Development—Strategies for Progress

Synthetic androgens for male contraception

Testosterone and male contraception

Contact Info

Product

Resources

About