Male Horse Meiosis: Metaphase I Chromosome Configuration and Chiasmata Distribution

Al-Jaru, A.; Goodwin, William; Skidmore, J.A.; Raudsepp, Terje; Khazanehdari, Kamal

doi:10.1159/000365910

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…In horse cytogenetics, immunostaining has been used to understand the organization, function, and evolution of centromeres [190,191] and for the study of synaptonemal complexes, recombination sites and the chiasmata in meiosis prophase and MI of normal stallions [192,193]. To date, immunostaining has not been used for the study of aberrant horse chromosomes.…”

Section: Immunolocalization Of Chromosomal Proteinsmentioning

confidence: 99%

Horse Clinical Cytogenetics: Recurrent Themes and Novel Findings

Bugno‐Poniewierska

Raudsepp

2021

Animals

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Clinical cytogenetic studies in horses have been ongoing for over half a century and clearly demonstrate that chromosomal disorders are among the most common non-infectious causes of decreased fertility, infertility, and congenital defects. Large-scale cytogenetic surveys show that almost 30% of horses with reproductive or developmental problems have chromosome aberrations, whereas abnormal karyotypes are found in only 2–5% of the general population. Among the many chromosome abnormalities reported in the horse, most are unique or rare. However, all surveys agree that there are two recurrent conditions: X-monosomy and SRY-negative XY male-to-female sex reversal, making up approximately 35% and 11% of all chromosome abnormalities, respectively. The two are signature conditions for the horse and rare or absent in other domestic species. The progress in equine genomics and the development of molecular tools, have qualitatively improved clinical cytogenetics today, allowing for refined characterization of aberrations and understanding the underlying molecular mechanisms. While cutting-edge genomics tools promise further improvements in chromosome analysis, they will not entirely replace traditional cytogenetics, which still is the most straightforward, cost-effective, and fastest approach for the initial evaluation of potential breeding animals and horses with reproductive or developmental disorders.

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Section: Immunolocalization Of Chromosomal Proteinsmentioning

confidence: 99%

Horse Clinical Cytogenetics: Recurrent Themes and Novel Findings

Bugno‐Poniewierska

Raudsepp

2021

Animals

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Chromosome Aberrations and Fertility Disorders in Domestic Animals

Raudsepp

Chowdhary

2016

Annu. Rev. Anim. Biosci.

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The association between chromosomal abnormalities and reduced fertility in domestic animals is well recorded and has been studied for decades. Chromosome aberrations directly affect meiosis, gametogenesis, and the viability of zygotes and embryos. In some instances, balanced structural rearrangements can be transmitted, causing fertility problems in subsequent generations. Here, we aim to give a comprehensive overview of the current status and future prospects of clinical cytogenetics of animal reproduction by focusing on the advances in molecular cytogenetics during the genomics era. We describe how advancing knowledge about animal genomes has improved our understanding of connections between gross structural or molecular chromosome variations and reproductive disorders. Further, we expand on a key area of reproduction genetics: cytogenetics of animal gametes and embryos. Finally, we describe how traditional cytogenetics is interfacing with advanced genomics approaches, such as array technologies and next-generation sequencing, and speculate about the future prospects.

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Male Horse Meiosis: Metaphase I Chromosome Configuration and Chiasmata Distribution

Cited by 2 publications

References 31 publications

Horse Clinical Cytogenetics: Recurrent Themes and Novel Findings

Horse Clinical Cytogenetics: Recurrent Themes and Novel Findings

Chromosome Aberrations and Fertility Disorders in Domestic Animals

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