Male infertility: Decreased levels of selenium, zinc and antioxidants

Türk, Silver; Mändar, Reet; Mahlapuu, Riina; Viitak, Anu; Punab, Margus; Kullisaar, Tiiu

doi:10.1016/j.jtemb.2013.12.005

Cited by 61 publications

(45 citation statements)

References 44 publications

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“…In the present study, we demonstrated a significantly lower zinc level in seminal plasma of the diabetic group in comparison with the nondiabetic controls. Although we did not find data on the Zn status in seminal plasma of diabetic men, Turk et al have reported low levels of Zn in seminal plasma of infertile men compared with control [23]. Other studies did not find significant difference in Zn level of semen between fertile and infertile men [24,25].…”

Section: Discussioncontrasting

confidence: 78%

Seminal plasma zinc and magnesium levels and their relation to spermatozoa parameters in semen of diabetic men

Ghasemi

Karimi

Goodarzi

et al. 2015

Int J Diabetes Dev Ctries

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There is a growing body of evidence that diabetic conditions are associated with sexual problems. Metabolism of trace elements is altered in diabetic mellitus, and they may have a specific role in the pathogenesis and progression of the disease. The aims of this study are to investigate the levels of zinc and magnesium in semen of patients with diabetes mellitus and to find out if there is any association between trace elements and semen parameters in these diabetic subjects. Semen samples from 25 diabetic men and 25 nondiabetic were analyzed for physical and biochemical parameters. Zinc (Zn) and magnesium (Mg) levels were estimated by atomic absorption spectrophotometry. Zn and Mg concentrations in seminal plasma of nondiabetic men were more elevated than in diabetic groups. Zn showed positive and significant correlations with sperm motility (p<0.05, r=0.52) and morphology (p<0.05, r=0.44). Mg was significantly correlated with sperm motility (p <0.05, r = 0.51) and morphology (p<0.05, r=0.48). Seminal plasma Zn and Mg showed a negative correlation with HbA1c, which was statistically significant (r=−0.380 and r=−0.367, p<0.05). Zn and Mg deficiencies become visible as an additional risk factor in the development of diabetes, and they are involved in the pathogenesis of diabetes mellitus and its complications. Adequate administration of these elements may be an effective therapeutic intervention in the prevention of the progression of the diabetes and its complications, along with a glycemic control and control of other risk factors.

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Section: Discussioncontrasting

confidence: 78%

Seminal plasma zinc and magnesium levels and their relation to spermatozoa parameters in semen of diabetic men

Ghasemi

Karimi

Goodarzi

et al. 2015

Int J Diabetes Dev Ctries

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“…Several contradictory studies have examined the correlations between seminal plasma Zn levels and human fertility (Zhao et al, 2016). Some studies showing that Zn concentrations in the seminal plasma of infertile men were significantly lower than those of normal fertile men; however, other studies did not report this finding (Akinloye, Abbiyesuku, Oguntibeju, Arowojolu, & Truter, 2011;Camejo et al, 2011;Jawad, 2013;Turk et al, 2014). Trace elements Fe and Cu are essential for normal physiology of the male genitalia tissues (Tvrda, Peer, Sikka, & Agarwal, 2015).…”

Section: Discussionmentioning

confidence: 99%

The relationship between seminal plasma and serum trace elements and semen parameters of dromedary camels (Camelus dromedarius)

Waheed

Meligy

Dhalam³

2018

Reprod Domestic Animals

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A total of 14 camels of known fertility (controls) at the Camel Research Centre, King Faisal University and 41 infertile dromedaries brought to the Veterinary Teaching Hospital were used in this study during the breeding season. Seminal plasma and serum were obtained from all males, and stored at -80°C until analysis. Concentrations of six trace elements (manganese [Mn], zinc [Zn], iron [Fe], selenium [Se], copper [Cu] and chromium [Cr]) were estimated in the seminal plasma and serum using an atomic absorption spectrophotometer. Results showed significant (p < 0.05 and p < 0.01) differences in semen pH and sperm motility, concentration and abnormalities between the control and infertile dromedaries. In seminal plasma, a significant (p < 0.01) difference in Fe concentrations (7.792 ± 1.567 vs. 61.259 ± 11.967 mg/L) and significant (p < 0.05) differences in Zn (24.763 ± 8.206 vs. 83.981 ± 4.972 mg/L) and Cu (1.653 ± 0.348 vs. 7.905 ± 1.134 mg/L) concentrations existed between the control and infertile dromedaries, respectively. In serum, there were significant (p < 0.05) differences in Fe (6.237 ± 0.695 vs. 151.121 ± 27.604 mg/L) and Cu (24.703 ± 4.195 vs. 6.375 ± 0.644 mg/L) concentrations and a significant (p < 0.01) difference in Zn concentrations (17.086 ± 1.606 vs. 90.422 ± 4.347 mg/L) between the fertile and infertile camels, respectively. There were significant (p < 0.05) positive (r = 0.51) and negative (r = -0.54) correlations between Zn concentrations in seminal plasma and both sperm motility and sperm abnormalities, respectively. In conclusion, seminal plasma and serum trace elements of Fe, Zn and Cu influenced the semen parameters and fertility of dromedary camels. Low concentrations of Fe, Zn and Cu in the seminal plasma were associated with normal fertility in dromedaries.

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“…Selenium (Se) is a trace element with strong antioxidant and anti-inflammatory properties and reduces the risk of cancer, including prostate cancer (Christensen 2014). Infertile men have lower Se concentrations in seminal plasma, and positive correlations exist between sperm parameters and serum Se levels (Eroglu et al 2014;Turk et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging

Rotter

Kosik-Bogacka

Dołęgowska

et al. 2015

Environ Geochem Health

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Beyond 30 years of age, men experience a decline in the production of testosterone, yet only a few develop late-onset hypogonadism. This study was designed to determine the relationship between blood concentrations of metals, macro- and micronutrients and age-related testosterone deficiency and associated hormonal changes in aging men. The research involved 313 men aged 50-75 years. We used ELISA to determine the concentrations of total testosterone (TT), free testosterone (FT), estradiol (E2), dehydroepiandrosterone sulfate (DHEAS) and sex hormone-binding globulin (SHBG). We calculated free androgen index (FAI). With the use of emission spectrometry in inductively coupled argon plasma, we determined the whole-blood concentrations of lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As) and tungsten (W), as well as serum concentrations of magnesium (Mg), iron (Fe), calcium (Ca), copper (Cu), zinc (Zn), selenium (Se), chromium (Cr), manganese (Mn) and molybdenum (Mo). The study showed no relationship between TT and FT and the concentrations of metals. Men with TT deficiency had significantly lower concentrations of Mg and Fe and increased Mn. Men with FT deficiency had higher W and Cr levels and lower Fe. Assessing the correlation between the concentrations of hormones, SHBG and FAI, and the concentration of metals and macro- and microelements in the blood of the men, we found positive correlations between the concentrations of TT-Mg, TT-Fe, TT-Mo, FT-Fe, E2-As, SHBG-Mn, FAI-W, FAI-As, FAI-Zn and FAI-Ca, and negative correlations between the concentrations of TT-Mn, FT-Cd, FT-Cr, E2-Hg, E2-Cr, SHBG-W, SHBG-As, SHBG-Zn, SHBG-Ca, FAI-Pb and FAI-Mn. Positive correlations between As and E2 and between As and FAI may suggest a lack of association between this metal and hypogonadism in people not exposed to excess As levels. Our research indicates a positive relationship between the concentrations of Mg, Fe and Zn and endocrine system in aging men, in contrast to Mn and Cr. Toxic metals (Cd, Pb) seemed to negatively affect the level of bioavailable testosterone. In persons not exposed to As, As does not contribute late-onset hypogonadism. Heavy metals (Pb, Cd, Hg and W) may contribute to a lower concentration of DHEAS. The role of W in men with LOH was found to be ambiguous, as on the one hand its concentration was higher in men with FT deficiency, and on the other hand it positively correlated with FAI, which in turn indirectly indicates testosterone availability. Copper and selenium do not seem to play any significant role in the occurrence of TT deficiency in aging men.

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Male infertility: Decreased levels of selenium, zinc and antioxidants

Cited by 61 publications

References 44 publications

Seminal plasma zinc and magnesium levels and their relation to spermatozoa parameters in semen of diabetic men

Seminal plasma zinc and magnesium levels and their relation to spermatozoa parameters in semen of diabetic men

The relationship between seminal plasma and serum trace elements and semen parameters of dromedary camels (Camelus dromedarius)

Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging

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