Male‐mediated prenatal loss: Functions and mechanisms

Zipple, Matthew N.; Roberts, Eila K.; Alberts, Susan C.; Beehner, Jacinta C.

doi:10.1002/evan.21776

Cited by 28 publications

(25 citation statements)

References 101 publications

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“…Geladas are ideal candidates for this investigation because we already know that female reproduction is sensitive to the arrival of novel males in this species. For example, female geladas exhibit male-mediated pregnancy termination, or ''the Bruce effect,'' 27,28 following the arrival of a novel breeding male. Furthermore, novel males also prompt lactating females to resume signs of fertility (sexual swellings) in what appears to be an estrous condition.…”

Section: Resultsmentioning

confidence: 99%

Male-Mediated Maturation in Wild Geladas

Feder

Snyder‐Mackler

et al. 2021

Current Biology

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Section: Resultsmentioning

confidence: 99%

Male-Mediated Maturation in Wild Geladas

Feder

Snyder‐Mackler

et al. 2021

Current Biology

Self Cite

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“…Therefore, the missing neural substrates do not altogether preclude a human Bruce-like effect, but do restrict such an analogy. Finally, whereas in the Bruce effect the pregnancy is terminated at the stage of implantation, in humans this would be almost impossible to identify, and women who are diagnosed with uRPL are past the implantation phase ( Zipple et al, 2019 ). With these limitations in mind, we restrict our claims to the observation of altered perceptual and brain responses to men's body-odor in uRPL.…”

Section: Discussionmentioning

confidence: 99%

Unexplained repeated pregnancy loss is associated with altered perceptual and brain responses to men’s body-odor

Rozenkrantz

Weissgross

Weiss

et al. 2020

eLife

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Mammalian olfaction and reproduction are tightly linked, a link less explored in humans. Here, we asked whether human unexplained repeated pregnancy loss (uRPL) is associated with altered olfaction, and particularly altered olfactory responses to body-odor. We found that whereas most women with uRPL could identify the body-odor of their spouse, most control women could not. Moreover, women with uRPL rated the perceptual attributes of men's body-odor differently from controls. These pronounced differences were accompanied by an only modest albeit significant advantage in ordinary, non-body-odor-related olfaction in uRPL. Next, using structural and functional brain imaging, we found that in comparison to controls, most women with uRPL had smaller olfactory bulbs, yet increased hypothalamic response in association with men's body-odor. These findings combine to suggest altered olfactory perceptual and brain responses in women experiencing uRPL, particularly in relation to men's body-odor. Whether this link has any causal aspects to it remains to be explored.

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“…This may improve maternal fitness by delaying reproductive investment until conditions have improved . Such strategies include fetal loss in response to drought or infanticide risk, and other forms of curtailed postnatal maternal investment (e.g., early weaning) in response to similar conditions . Studies on birds provide some of the best evidence for such parent‐offspring conflict (Box 3).…”

Section: Adaptive Models Of Developmental Plasticitymentioning

confidence: 99%

Developmental responses to early‐life adversity: Evolutionary and mechanistic perspectives

Petrullo

Carrera

et al. 2019

Evolutionary Anthropology

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Adverse ecological and social conditions during early life are known to influence development, with rippling effects that may explain variation in adult health and fitness. The adaptive function of such developmental plasticity, however, remains relatively untested in long‐lived animals, resulting in much debate over which evolutionary models are most applicable. Furthermore, despite the promise of clinical interventions that might alleviate the health consequences of early‐life adversity, research on the proximate mechanisms governing phenotypic responses to adversity have been largely limited to studies on glucocorticoids. Here, we synthesize the current state of research on developmental plasticity, discussing both ultimate and proximate mechanisms. First, we evaluate the utility of adaptive models proposed to explain developmental responses to early‐life adversity, particularly for long‐lived mammals such as humans. In doing so, we highlight how parent‐offspring conflict complicates our understanding of whether mothers or offspring benefit from these responses. Second, we discuss the role of glucocorticoids and a second physiological system—the gut microbiome—that has emerged as an additional, clinically relevant mechanism by which early‐life adversity can influence development. Finally, we suggest ways in which nonhuman primates can serve as models to study the effects of early‐life adversity, both from evolutionary and clinical perspectives.

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Male‐mediated prenatal loss: Functions and mechanisms

Cited by 28 publications

References 101 publications

Male-Mediated Maturation in Wild Geladas

Male-Mediated Maturation in Wild Geladas

Unexplained repeated pregnancy loss is associated with altered perceptual and brain responses to men’s body-odor

Developmental responses to early‐life adversity: Evolutionary and mechanistic perspectives

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