Male microchimerism in women without sons: Quantitative assessment and correlation with pregnancy history

Zhen, Yan; Lambert, Nathalie; Guthrie, Katherine A.; Porter, Allison J.; Loubière, Laurence; Madeleine, Margaret M.; Stevens, Anne M.; Hermes, H.; Nelson, J. Lee

doi:10.1016/j.amjmed.2005.03.037

Cited by 121 publications

(106 citation statements)

References 27 publications

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“…In the other 11 cases, DYZ1 was regarded as being not informative, since the women gave birth to a daughter. In line with other reports, 132,133 we observed in a more recent analysis of a larger group of women with no sons, i.e., nulliparous women or females who had given birth to a daughter, a fairly high percentage of women displaying male microchimerism. 86 With HLA-directed primers, 6 out of 19 (32%) showed weak or clear positivity of fetal microchimerism (Fig.…”

Section: Pcr-based Methodologiessupporting

confidence: 93%

Naturally acquired microchimerism

et al. 2014

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Section: Pcr-based Methodologiessupporting

confidence: 93%

Naturally acquired microchimerism

et al. 2014

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“…While it was long believed that fetal cells and antigens do not cross the 'placental barrier', it is now well documented that microchimerism do occur during murine and human pregnancy. [33][34][35][36][37] Khosrotehrani and colleagues 38 described the presence of paternal antigens in maternal organs throughout all stages of pregnancy in mouse. This was further confirmed by us after mating wild-type females with GFP + transgenic males.…”

Section: Generation Of Treg In Pregnancy and Antigen Specificitymentioning

confidence: 99%

REVIEW ARTICLE: Regulatory T Cells and Their Role in Pregnancy

Leber

Teles

Zenclussen

2010

American J Rep Immunol

148

116

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Citation Leber A, Teles A, Zenclussen AC. Regulatory T cells and their role in pregnancy. Am J Reprod Immunol 2010Regulatory T cells emerge in the last years as key players in allowing fetal survival within the maternal uterus. They were shown to be a unique subpopulation of T cells expanding during human and murine pregnancy. The importance of Treg for a normal pregnancy situation was proven by studies showing that their absence impairs murine pregnancy while the adoptive transfer of Treg prevents fetal rejection. In humans, pregnancy pathologies are associated with lower Treg frequencies while therapies that improve pregnancy outcome are able to boost their number. Functional studies have shown that Treg can regulate immune cell responses directly at the fetal–maternal interface either by interacting with other cells or by inducing the expression of immune regulatory molecules. This article revises relevant literature on regulatory T cells in human and murine pregnancy.

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“…This has previously been demonstrated in healthy women and women with autoimmune diseases, as the result of transplacental traffic of cells during pregnancy, 10 whether complete or incomplete. 11,12 It could also be iatrogenic for women who had a BT from a male donor, as previously described in immune competent transfusion recipients. 13 Or it could be from both origins, which are not distinguishable with the quantification method we used based on sex mismatch by PCR of a Y chromosome sequence.…”

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confidence: 89%