Male osteoporosis: A review

Herrera, Antonio; Lobo-Escolar, Antonio; Mateo, Jesús; Gil, J. Fragio; Ibarz, Elena; Gracia, Luis

doi:10.5312/wjo.v3.i12.223

Cited by 38 publications

(29 citation statements)

References 130 publications

(153 reference statements)

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“…There was a significant difference in Group III in respect of age. A significant decrease in BMD in that age group is not expected [17]. Nevertheless, multivariate analysis with logistic regression was applied and the age did not significantly affect the BMD.…”

Section: Discussionmentioning

confidence: 92%

Evaluation of bone mineral density and 25-hydroxyvitamin D levels in subjects with silica exposure

Yıldızgören

Öziş

Baki

et al. 2016

Environ Health Prev Med

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Objective The purpose of the study was to evaluate the bone mineral density (BMD) and 25-hydroxyvitamin D (25(OH)D) levels in patients with silica exposure. Materials and methods The study included 104 male subjects with silica exposure and 36 healthy subjects. Posterior-anterior radiographs were classified according to the International Labour Office (ILO) Classification. Category 0 patients were classified as Group I (n = 54), category I patients were classified as Group II (n = 25), Category II and III patients were classified as Group III (n = 25). Results Femoral neck BMD values were significantly lower in Group III (p = 0.007). Lumbar vertebrae BMD values were significantly lower in all groups with silica exposure than in the control group (p = 0.000). The osteoporosis rate was significantly higher in Group III (p = 0.000). Subjects with silica exposure were determined to have diminished 25(OH)D levels (p = 0.012). ConclusionThe results of this study demonstrated that subjects with silica exposure have diminished BMD and 25(OH)D levels.

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Section: Discussionmentioning

confidence: 92%

Evaluation of bone mineral density and 25-hydroxyvitamin D levels in subjects with silica exposure

Yıldızgören

Öziş

Baki

et al. 2016

Environ Health Prev Med

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“…In aging men reduced calcium absorption in the intestine results in lower serum concentration of ionized calcium. This leads to an increase in the production of parathyroid hormone (PTH), which stimulates osteoclasts (Herrera et al 2012). It is believed that the reduced testosterone levels may contribute to dysregulation of intracellular Ca 2?…”

Section: Introductionmentioning

confidence: 99%

Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine disorders associated with male aging

Rotter

Kosik-Bogacka

Dołęgowska

et al. 2015

Environ Geochem Health

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Beyond 30 years of age, men experience a decline in the production of testosterone, yet only a few develop late-onset hypogonadism. This study was designed to determine the relationship between blood concentrations of metals, macro- and micronutrients and age-related testosterone deficiency and associated hormonal changes in aging men. The research involved 313 men aged 50-75 years. We used ELISA to determine the concentrations of total testosterone (TT), free testosterone (FT), estradiol (E2), dehydroepiandrosterone sulfate (DHEAS) and sex hormone-binding globulin (SHBG). We calculated free androgen index (FAI). With the use of emission spectrometry in inductively coupled argon plasma, we determined the whole-blood concentrations of lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As) and tungsten (W), as well as serum concentrations of magnesium (Mg), iron (Fe), calcium (Ca), copper (Cu), zinc (Zn), selenium (Se), chromium (Cr), manganese (Mn) and molybdenum (Mo). The study showed no relationship between TT and FT and the concentrations of metals. Men with TT deficiency had significantly lower concentrations of Mg and Fe and increased Mn. Men with FT deficiency had higher W and Cr levels and lower Fe. Assessing the correlation between the concentrations of hormones, SHBG and FAI, and the concentration of metals and macro- and microelements in the blood of the men, we found positive correlations between the concentrations of TT-Mg, TT-Fe, TT-Mo, FT-Fe, E2-As, SHBG-Mn, FAI-W, FAI-As, FAI-Zn and FAI-Ca, and negative correlations between the concentrations of TT-Mn, FT-Cd, FT-Cr, E2-Hg, E2-Cr, SHBG-W, SHBG-As, SHBG-Zn, SHBG-Ca, FAI-Pb and FAI-Mn. Positive correlations between As and E2 and between As and FAI may suggest a lack of association between this metal and hypogonadism in people not exposed to excess As levels. Our research indicates a positive relationship between the concentrations of Mg, Fe and Zn and endocrine system in aging men, in contrast to Mn and Cr. Toxic metals (Cd, Pb) seemed to negatively affect the level of bioavailable testosterone. In persons not exposed to As, As does not contribute late-onset hypogonadism. Heavy metals (Pb, Cd, Hg and W) may contribute to a lower concentration of DHEAS. The role of W in men with LOH was found to be ambiguous, as on the one hand its concentration was higher in men with FT deficiency, and on the other hand it positively correlated with FAI, which in turn indirectly indicates testosterone availability. Copper and selenium do not seem to play any significant role in the occurrence of TT deficiency in aging men.

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“…Denosumab tiene también indicación en el tratamiento de la pérdida ósea asociada a la supresión hormonal en hombres con cáncer de próstata con elevado riesgo de fractura. La terapia con testosterona no se recomienda como tratamiento estándar por sus efectos secundarios asociados 132 .…”

Section: Concepto De Fallo En El Tratamientounclassified