Male Partners of Infertile Couples with Seminal Infections of Human Papillomavirus Have Impaired Fertility Parameters

Damke, Edílson; Kurscheidt, Fábio A.; Balani, Valério Américo; Takeda, Karen I.; Irie, Mary Mayumi Taguti; Gimenes, Fernanda Raphael Escobar; Consolaro, Márcia Edilaine Lopes

doi:10.1155/2017/4684629

Cited by 38 publications

(60 citation statements)

References 32 publications

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“…The HR-HPV genotypes found in this study were the same as those reported from sperm derived from duct biopsy with high prevalence of 31% in Finland [21]. In contrast to this study where HPV and 18 were less represented, these two genotypes were predominant in other studies conducted in Amsterdam and Brazil [12,22]. Our results are consistent with those of other authors who found that HPV 16 and 18 genotypes are more common in Europe, America and Africa [14,16,[23][24][25].…”

Section: Discussionsupporting

confidence: 81%

“…In addition, it is recognized that HPV DNA in urine and sperm positively reflect the presence of HPV in the " internal " reservoirs [10]. Studies have reported that HPV infection affects fertility parameters in humans [11,12]. In Burkina Faso, previous studies have been carried out in women and reported the frequency of other high-risk HPV genotypes outside genotypes 16 and 18 [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Carriage of high-risk human papillomavirus infection in male subjects in Ouagadougou, Burkina Faso

Tamini

Zohoncon²,

Soubeïga³

et al. 2019

Preprint

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Background Human papillomavirus (HPV) infection is a public health problem in Africa because of its frequency and its various consequences in both men and women. In Burkina Faso, there is little data on the carriage of HPV infection in male subjects. This study aimed to determine the carriage of HPV infection in male subjects in Ouagadougou, Burkina Faso.Methods This was a cross-sectional study conducted from December 2015 to September 2016. During this study period, a total of 124 male subjects who gave informed consent were recruited as part of a fertility assessment. Semen samples were analyzed by Real- Time PCR using Real TM Quant High Risk Screen HPV kit to detect 14 high-risk HPV genotypes. The Chi square test was used for comparisons.Results Of the 124 male subjects, 22 were positive for at least one high-risk HPV, with a prevalence of 17.7%. HPV 56 was the most represented genotype with a frequency of 20%, followed by HPV 39 (11%) and HPV 68 (11%), HPV 16 (8%). The genotypes HPV 18, HPV33, HPV35, HPV51 and HPV52 also had the same frequency of 6% each and the HPV 31, 45, 59 and 66 had the same frequency of 3% each. Of the 22 positive cases, 10 were multiple infections. Spermocytogram of patients showed at least one abnormality in 87.9% of cases. Necrozoospermia and oligozoospermia were the most abnormalities observed with 42% and 40% respectively followed by asthenospermia (18%); teratozoospermia (16%) and azoospermia (14%).Conclusion This study showed that like women, men are infected by HPV with a relatively high prevalence. In addition, the predominant genotypes in the male subjects of this study are not those targeted by the HPV vaccines available in our countries. Hence the need to reinforce the strategies for controlling HPV infection and HPV prophylactic vaccination for young boys.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Carriage of high-risk human papillomavirus infection in male subjects in Ouagadougou, Burkina Faso

Tamini

Zohoncon²,

Soubeïga³

et al. 2019

Preprint

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“…Nevertheless, in spite of all the maintenance, repair, and defense systems in place, damage to biosignaling systems is inevitable and morbidities occur at multiple levels. Necessary interactions are, as noted earlier, susceptible to injuries from toxins [81], [203]- [210], trauma from radiant energy (particles or waves; [211]), as well as interactive injuries that may spill over from pathogens [212]- [217], and even ruptured membranes owed to bruising of parental gametes can contribute to inappropriately extreme immune responses [218].…”

Section: Immune Defenses From the Beginning?mentioning

confidence: 99%

From Superficial Damage to Invasion of the Nucleosome: Ranking of Morbidities by the Biosemiotic Depth Hypothesis

Oller¹,

Shaw²

2019

ijSciences

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At their most abstract level, according to a certain generalized paradigm in biosemiotic philosophy grounded in well-established mathematical proofs, valid communications from molecules upward must be formally isomorphic to the dynamic true narrative representations (TNRs) of natural language systems that vest those meaningful signs with their functional (pragmatic) content. TNRs, in DNA, RNA, proteins, and higher constructions, therefore, are requisite to health in the individual, in interactions with the larger environment, and with other organisms. In homo sapiens, the generalized biosemiotic paradigm proves that morbidities in general must always, in some manner, involve degradation of internal and external communications through TNRs in DNA, RNA, protein language, organelles, cells, tissues, and organ systems. The mathematically grounded paradigm shows that any given TNR can be superveniently degenerated, by very coarse or very fine degrees, to many distinct fictions, errors, lies, and nonsense strings out to the absolute limit of a complete erasure. The depth hypothesis asserts that if the timing and breadth of any degenerative disruption can be held equal, in fact or in principle, the depth of penetration of any disruptive factor into biosignaling representations must in theory be pathognomonic of severity in the supervened morbidities. From meiosis through conception to maturity, ceteris paribus, corruptions deeper in the developmental hierarchy must be more harmful in the morbidities they supervene. The depth hypothesis suggests a differentiation of autoimmune disorders as deeper than allergies, but less so than prion diseases, tumorigenesis, and metastatic cancers in that order. It suggests, therefore, a potentially useful generalized ranking of morbidities.

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“…Increase of semen viscosity was observed in the samples infected with the virus in single and multiple forms. Hypospermia, leukocytospermia and increased pH are found in infected samples with multiple types of HPV, probably the seminal changes are related to the negative effects of different forms of HPV in the prostate secretion and the fertility [53].…”

Section: Volume and Seminal Viscositymentioning

confidence: 99%

Male Accessory Glands and Sperm Function

Ricardo¹

2018

Spermatozoa - Facts and Perspectives

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With the advent of the techniques of reproduction, the functions of this fluid on the sperm function became a topic of lesser interest to the embryologist, urologist and andrologist. The interaction of spermatozoa with seminal plasma often goes unnoticed, but it is very likely that many substances produced by male accessory glands have impact on the sperm physiology. Seminal fluid contains several components besides spermatozoa; many of them are produced by a specific tissue and can be useful markers of secretion of the glands. The information in the 5th Manual of World Health Organization is very limited with respect to the interpretation in several characteristics abnormally high in semen. Male accessory glands secrete several factors such as alpha-glucosidase, fructose, prostaglandins, bicarbonate and citric acid among others, which are crucial for sperm physiology. This chapter deals with the interpretation of markers of accessory glands and their relation to some pathologies such as varicocele, infections, obstructions of the seminiferous pathways and some hormonal alterations.

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Male Partners of Infertile Couples with Seminal Infections of Human Papillomavirus Have Impaired Fertility Parameters

Cited by 38 publications

References 32 publications

Carriage of high-risk human papillomavirus infection in male subjects in Ouagadougou, Burkina Faso

Carriage of high-risk human papillomavirus infection in male subjects in Ouagadougou, Burkina Faso

From Superficial Damage to Invasion of the Nucleosome: Ranking of Morbidities by the Biosemiotic Depth Hypothesis

Male Accessory Glands and Sperm Function

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