Male reproductive toxicity of inorganic nanoparticles in rodent models: A systematic review

Dantas, Graziela P F; Ferraz, F. S.; Andrade, Lídia M.; Costa, Guilherme Mattos Jardim

doi:10.1016/j.cbi.2022.110023

Cited by 21 publications

(11 citation statements)

References 113 publications

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“…In recent years, the usage of engineered nanomaterials for various biomedical and industrial purposes has significantly increased, raising multiple worries concerning harmful consequences on animal and human health [ 1 ]. In particular, the toxicological effects of inorganic nanoparticles (NPs) on reproductive organs have lately come to light [ 2 ]. Numerous studies have demonstrated that several NPs such as silver (Ag NPs), titanium dioxide (TiO 2 NPs), and aluminum trioxide (Al 2 O 3 NPs) can alter the integrity of the blood–testis barriers (BTB) [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats

et al. 2022

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This study examined the effects of exposure to lead acetate (PbAc) and/or aluminum trioxide nanoparticles (Al2O3NPs) on testicular function. Additionally, the probable reproprotective effects of quercetin (QTN) against Al2O3NPs and PbAc co-exposure in male Sprague Dawely rats were assessed. Al2O3NPs (100 mg/kg b.wt.), PbAc (50 mg/kg b.wt.), and QTN (20 mg/kg b.wt.) were orally administered for 60 days. Then, spermiogram, histopathological examinations of the testis and accessory glands, and immunohistochemical detection of androgen receptors (AR) and tumor necrotic factor alpha (TNF-α) were achieved. Moreover, serum levels of male sex hormones and testicular levels of antioxidant indices were estimated. The results showed that Al2O3NPs and/or PbAc caused significant sperm abnormalities, testicular oxidative stress, and histopathological changes. Furthermore, serum testosterone, LH, and FSH levels significantly decreased, while estradiol levels significantly increased. The Al2O3NPs and/or PbAc co-exposed group had more obvious disturbances. Furthermore, QTN co-administration significantly reversed the Al2O3NPs and PbAc-induced testicular histopathological alterations, reduced antioxidant defenses, and altered AR and TNF-α immune expression in testicular tissues. Conclusively, Al2O3NPs and/or PbAc evoked testicular dysfunction by inducing oxidative injury and inflammation. However, QTN oral dosing effectively mitigated the negative effects of Al2O3NPs and PbAc by suppressing oxidative stress and inflammation and improving the antioxidant defense system.

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Section: Introductionmentioning

confidence: 99%

Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats

et al. 2022

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“…At Stage III, GNR particles aggregated and were mainly located in the mitochondria and possibly other subcellular organelles. The GNRs are proposed to cause some agglutination in mitochondria [ 36 ]. GNRs ruptured the endosomal/lysosomal membrane, resulting in the release of nanorods and affecting the mitochondria.…”

Section: Resultsmentioning

confidence: 99%

Cell-Based Metabolomics Approach for Anticipating and Investigating Cytotoxicity of Gold Nanorods

Sun

Zhang

et al. 2022

Foods

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Despite the increasing application of gold nanoparticles, there has been little assessment of biological system toxicity to evaluate their potential impact on human health. In this study, the human hepatoma cell line (Hep G2) was used in a metabolomics approach to study the effects of shape, time, and dose of gold nanorods (GNRs). Using optimized parameters for chromatography and mass spectrometry, the metabolites detected by GC-MS were processed with MS DIAL and identified with Fiehnlib. Key metabolic pathways affected by GNRs were identified by endo-metabolic profiling of cells mixed with GNRs of varying shape while varying the dose and time of exposure. The shape of GNRs affected cytotoxicity, and short GNR (GNR−S) triggered disorder of cell metabolism. High concentrations of GNRs caused more significant toxicity. The cytotoxicity and bioTEM results illustrated that the mitochondria toxicity, as the main cytotoxicity of GNRs, caused declining cytoprotective ability. The mitochondrial dysfunction disrupted alanine, aspartate, glutamate, arginine, and proline metabolism, with amino acid synthesis generally downregulated. However, the efflux function of cells can exclude GNRs extracellularly within 24 h, resulting in reduced cell mitochondrial metabolic toxicity and allowing metabolic disorders to recover to normal function.

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“…Additionally, AuNP toxicity is strongly related to by-products generated during the synthesis and functionalization processes, type of surfactants and their concentration, route of administration, size, charge, and shape [ 66 ]. For instance, it has already been demonstrated that the smallest nanoparticles are the most cytotoxic [ 67 , 68 ].…”

Section: Discussionmentioning

confidence: 99%

Insights into Gold Nanoparticles Possibilities for Diagnosis and Treatment of the Head and Neck Upper Aerodigestive Tract Cancers

Andrade

Costa

2023

Cancers

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Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer affecting people and accounts for more than 300,000 deaths worldwide. Improvements in treatment modalities, including immunotherapy, have demonstrated promising prognoses for eligible patients. Nevertheless, the five-year overall survival rate has not increased significantly, and the tumor recurrence ratio remains at 50% or higher, except for patients with HPV-positive HNSCC. Over the last decades, nanotechnology has provided promising tools, especially for biomedical applications, due to some remarkable physicochemical properties of numerous nanomaterials, particularly gold nanoparticles. This review addresses the features and some applications of gold nanoparticles reported in the literature over the last five years regarding the diagnosis and treatment of head and neck cancer, highlighting the exciting possibilities of this nanomaterial in oncology. Methods: The scientific papers selected for this review were obtained from the PubMed Advanced, Web of Science, Scopus, ClinicalTrials.gov, and Google Scholar platforms. Conclusions: Results from papers applying gold nanoparticles have suggested that their application is a feasible approach to diagnostics, prognostics, and the treatment of HNC. Moreover, phase I clinical trials suggest that gold nanoparticles are safe and can potentially become theranostic agents for humans.

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Male reproductive toxicity of inorganic nanoparticles in rodent models: A systematic review

Cited by 21 publications

References 113 publications

Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats

Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats

Cell-Based Metabolomics Approach for Anticipating and Investigating Cytotoxicity of Gold Nanorods

Insights into Gold Nanoparticles Possibilities for Diagnosis and Treatment of the Head and Neck Upper Aerodigestive Tract Cancers

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