Male sex and Breslow thickness are important risk factors for recurrence of localized melanoma in Korean populations

Oh, Yeongjoo; Choi, Sooyie; Cho, Mi Yeon; Nam, Kyoung Ae; Shin, Sang Joon; Chang, Jee Suk; Oh, Byung Ho; Roh, Mi Ryung; Chung, Kee Yang

doi:10.1016/j.jaad.2019.09.029

Cited by 16 publications

(10 citation statements)

References 30 publications

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“…Partial biopsy has a significantly lower diagnostic accuracy than complete excision biopsy, which is considered the gold standard for the diagnosis of skin tumors, including melanoma. The excision biopsy of AM can be challenging due to its relatively larger Breslow thickness and volume when compared to other melanoma subtypes ( 7 , 8 ). Accurate determination of preoperative Breslow thickness in AM poses a significant clinical challenge.…”

Section: Introductionmentioning

confidence: 99%

The utility of high-frequency 18 MHz ultrasonography for preoperative evaluation of acral melanoma thickness in Chinese patients

Yu,

Huang,

et al. 2023

Front. Oncol.

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BackgroundDespite the increasing use of preoperative ultrasound evaluation for melanoma, there is limited research on the use of this technique for Acral Melanoma (AM).MethodsThis retrospective study analyzed the electronic medical records of patients who underwent preoperative evaluation for cutaneous melanoma maximum thickness using an 18 MHz probe and histopathological examination between December 2017 and March 2021 at the Department of Dermatology in Xiangya Hospital, Central South University.ResultsA total of 105 patients were included in the study. The mean tumor thickness was 3.9 mm (s.d., 2.3), with 63% of the specimens showing ulceration and 44 patients showing lymph node metastasis. The results showed a good correlation between the high-frequency ultrasonography (HFUS) and histopathological thickness measurements, with a Spearman’s correlation coefficient of 0.83 [(95% CI 0.73–0.90) (P < 0.001)]. The positive predictive value (PPV) of sonography in identifying tumor thickness was also found to be high.ConclusionOur study suggests that high-frequency 18 MHz ultrasonography is an effective tool for the preoperative evaluation of AM thickness. The HFUS measurements correlated well with the histopathological thickness measurements, making it a valuable and reliable method for clinicians to assess the thickness of melanoma lesions preoperatively.

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Section: Introductionmentioning

confidence: 99%

The utility of high-frequency 18 MHz ultrasonography for preoperative evaluation of acral melanoma thickness in Chinese patients

Yu,

Huang,

et al. 2023

Front. Oncol.

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“…Similar ndings were also found in many other malignant tumors, for instance, melanoma, thyroid, non-small cell lung, gastric and hepatocellular cancers, etc. [14][15][16][17][18]. According to the SEER data, we found male LPS patients were generally older and had a higher proportion of high-grade tumors, which may lead to worse overall survival of male patients in the unadjusted analyses.…”

Section: Discussionmentioning

confidence: 99%

Gender Differences in Prognosis After Primary Resection for Retroperitoneal Liposarcoma

Ren,

Qi,

Zhao

et al. 2023

The American Surgeon™

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Background Current evidence regarding gender difference in retroperitoneal liposarcoma (RLPS) is scarce, so we sought to investigate whether gender may affect prognosis after primary resection of RLPS. Methods We used the Surveillance, Epidemiology, and End Results (SEER) database to identify RLPS patients from January 1973 to December 2015. Multivariate cox proportional hazard analysis was adopted to generate adjusted hazard ratio (AHR) and 95% confidence intervals (CIs) of survival outcomes. Results In total, 2108 RLPS patients, including 971 women and 1137 men, were identified, with a median follow-up of 45.0 (17.0-92.0) months. The 5-year and 10-year overall survival rates were 50.5% and 31.5% for men and 60.4% and 42.5% for women. The 5-year and 10-year disease-specific survival rates for men and women were 71.5%, 57.3% and 76.3%, 62.1%, respectively. We found men were associated with an increased risk of all-cause mortality (AHR 1.3, 95% CI 1.0-1.6, P = .017) but not disease-specific mortality (AHR 1.2, 95% CI .9-1.6, P = .246). The subgroup analyses revealed that men were associated with an increased risk of all-cause mortality in patients with low-grade tumors (AHR 1.8, 95% CI 1.3-2.5) or patients who received non-radical resection (AHR 1.6, 95% CI 1.2-2.1). In the subgroup of low-grade tumors, men were also associated with an increased risk of disease-specific mortality (AHR 2.0, 95% CI 1.2-3.3). Conclusion Men may have worse survival after primary resection of RLPS compared with women, especially in patients with low-grade tumors or patients who received non-radical resection. Gender-based disparities may deserve more attention in patients with RLPS.

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“…[20][21][22][23][24] Cho et al 24 showed that tumor thickness was significant risk factors for local recurrence and distant metastasis. Oh et al 25 reported that male sex and Breslow thickness are the prognostic factors for recurrence in Korean populations. Thomas et al 21 identified that male sex, increased tumor thickness, and tumors with ulceration were prognostic factors associated with locoregional recurrence and death in 900 patients with CM after surgery.…”

Section: Discussionmentioning

confidence: 99%

Factors influencing locoregional recurrence and distant metastasis in Asian patients with cutaneous melanoma after surgery: A retrospective analysis in a tertiary hospital in Taiwan

Chu

Chen

et al. 2021

Journal of the Chinese Medical Association

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Background: The goal of this study was to investigate the prognostic factors for locoregional recurrence and metastasis in patients with cutaneous melanoma (CM) who underwent surgery, especially in the acral lentiginous melanoma (ALM) subtype. Methods: This study was a retrospective review of patients who underwent surgery for CM at Taipei Veterans General Hospital between 2000 and 2018. We investigated the risk factors for locoregional and distant metastases. The association between clinicopathological factors and locoregional recurrence and distant metastasis of the CM and ALM subtypes was analyzed. In addition, the outcomes between the ALM and non-ALM groups were compared. Results: A total of 161 patients were included in the analysis. The most common histological subtype was ALM. The overall locoregional recurrence rate of CM was 13.0% and the distant metastasis rate was 42.9%, whereas that of the ALM subtype was 12.5% and 45.5%, respectively. In patients with CM, male sex, tumor with lymphovascular invasion, and positive lymph node status were the prognostic factors for both locoregional recurrence and distant metastasis. Among the patients with ALM, positive lymph node status was significantly associated with both locoregional recurrence and distant metastasis. Conclusion: In this cohort, factors influencing locoregional recurrence and distant metastasis were similar between the ALM and non-ALM groups. The above-recommended surgical margin did not show any benefit in either the CM or the ALM subtype. ALM can be handled using the same surgical strategy as CM in the Asian population.

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Male sex and Breslow thickness are important risk factors for recurrence of localized melanoma in Korean populations

Cited by 16 publications

References 30 publications

The utility of high-frequency 18 MHz ultrasonography for preoperative evaluation of acral melanoma thickness in Chinese patients

The utility of high-frequency 18 MHz ultrasonography for preoperative evaluation of acral melanoma thickness in Chinese patients

Gender Differences in Prognosis After Primary Resection for Retroperitoneal Liposarcoma

Factors influencing locoregional recurrence and distant metastasis in Asian patients with cutaneous melanoma after surgery: A retrospective analysis in a tertiary hospital in Taiwan

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