Male sexual dysfunction in renal transplant recipients: comparison to men awaiting transplant

Cummings, James M.; Boullier, John A.; Browne, Barry J.; Bose, Katrin; Emovon, Osemwegie E.

doi:10.1016/s0041-1345(02)04032-0

Cited by 11 publications

(8 citation statements)

References 10 publications

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“…Previous studies have reported a high prevalence of ED, ranging from 20% to 100%, in patients with ESRD in Western countries (2, 6, 7). Many studies have provided evidence that successful kidney transplantation may play an important role in ED improvement.…”

Section: Discussionmentioning

confidence: 99%

“…Eligible patients were asked to complete the IIEF‐5 item by personal interview within seven d before transplant, again at the third month and sixth month after transplant, once every six month within two yr, and once each year thereafter. The total scores were calculated, with normal erectile function defined as a score of 22 to 25; cases of ED were classified as mild (12–21), moderate (8–11), or severe (5–7).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Improved erectile function and sex hormone profiles in male Chinese recipients of kidney transplantation

Teng

Wang

Chen

2011

Clinical Transplantation

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Improved erectile function and sex hormone profiles in male Chinese recipients of kidney transplantation

Teng

Wang

Chen

2011

Clinical Transplantation

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“…There are, however, certain facts that can be cited as possible reasons. Sexual response is the result of a complex interaction between psychological and physiological factors [34], and the prevalence of several potential psychological causes of sexual problems such as depression is as high in renal transplant subjects as it is in ESRD patients [12]. In addition, the high prevalence of physiological causes of erectile dysfunction in the post‐renal transplant phase—such as anemia, diabetes mellitus, peripheral neuropathy, and altered pelvic hemodynamics as a consequence of harvesting either external or internal iliac arteries for kidney perfusion—may be the cause [8].…”

Section: Discussionmentioning

confidence: 99%

“…Although improvement in sexual dysfunction has been reported after transplantation [8], there are reports [4,9–11] that a significant proportion of recipients continue to report difficulties in sexual function even after a successful renal transplantation. One study reported that several aspects of sexual function were the same in ESRD patients on the waiting list and those after transplantation [12].…”

Section: Introductionmentioning

confidence: 99%

Sexual Function: A Comparison Between Male Renal Transplant Recipients and Hemodialysis Patients

Tavallaii

Mirzamani

Behzadi

et al. 2009

The Journal of Sexual Medicine

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Introduction For all the studies into the sexual health of kidney transplant recipients, there is a paucity of controlled studies regarding the difference in the sexual relationship of kidney transplant recipients and end-stage renal disease (ESRD) patients under hemodialysis. Aim We compared the sexual function of kidney transplant recipients and ESRD patients under hemodialysis in male patients. Main Outcome Measures The patients’ sexual function was assessed using the Relationship and Sexuality Scale. Method In this case-controlled study, 89 male renal transplant recipients and 25 male hemodialysis patients were randomly selected from the outpatient clinic of Baqiyatallah Hospital, Tehran, Iran, in 2006. The two groups were not significantly different in terms of age, living place, level of education, duration of ESRD (months), ESRD cause, and somatic comorbidities (Ifudu index). Results The renal transplant patients in comparison with the hemodialysis group reported a better overall sexual relationship (17.3 ± 0.6 vs. 21.6 ± 1.4; P = 0.001), and all subscales including sexual function (9.9 ± 0.3 vs. 11.4 ± 0.6; P = 0.03), sexual frequency (6.3 ± 0.3 vs. 7.4 ± 0.6; P = 0.04), and sexual fear (1.1 ± 0.2 vs. 2.8 ± 0.5; P = 0.001). In addition, kidney recipients had significantly more sexual intercourse in a 2-week period prior to the study (P = 0.008). Conclusions In our male population, kidney transplant recipients, in comparison with the ESRD patients under hemodialysis, reported a better sexual relationship.

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“…ED substantially affects the quality of life for HD [9,10] and posttransplant [11] patients. Renal transplantation has been reported to improve ED in some, but not all, patients [6][7][8][12][13][14][15][16][17][18][19]; furthermore, de novo ED has been reported after transplantation. In most studies, approximately half of patients with renal transplants report ED [20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Phosphodiesterase Type 5 Inhibitor Treatment for Erectile Dysfunction in Patients with End-Stage Renal Disease Receiving Dialysis or After Renal Transplantation

Lasaponara¹,

Sedigh²,

Pasquale

et al. 2013

The Journal of Sexual Medicine

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Introduction The phosphodiesterase type 5 (PDE5) inhibitors are generally well tolerated and effective for treating erectile dysfunction (ED), including in patients with significant comorbidity. Because of this benign safety profile, investigators have used PDE5 inhibitors to treat patients with ED and severe renal disease or those who have received renal transplants. Aim To assess safety and efficacy of PDE5 inhibitors in patients receiving dialysis or renal transplants. Main Outcome Measures Erectile function as assessed by the International Index of Erectile Function (IIEF) and Global Assessment Questions; adverse events (AEs). Methods We reviewed published studies of PDE5 inhibitors in patients receiving dialysis or renal transplants. Results In double-blind, placebo-controlled studies in patients receiving dialysis or renal transplants, sildenafil significantly improved erectile function as assessed by the IIEF, and 75–85% of patients reported improved erectile function on Global Assessment Questions; efficacy was more variable in less well-controlled studies. In >260 patients undergoing dialysis who received sildenafil in clinical studies, there were only six reported discontinuations because of AEs (headache [N=3], headache and nausea [N=1], gastrointestinal [N=1], and symptomatic blood pressure decrease [N=1]). In approximately 400 patients with renal transplants who received sildenafil, only three patients discontinued because of AEs. Vardenafil improved IIEF scores of up to 82% of renal transplant recipients in randomized, controlled studies (N=59, total), with no reported discontinuations because of AEs. Limited data also suggest benefit with tadalafil. Conclusions ED is common in patients undergoing renal dialysis or postrenal transplant and substantially affects patient quality of life. Sildenafil and vardenafil appear to be efficacious and well tolerated in patients receiving renal dialysis or transplant.

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Male sexual dysfunction in renal transplant recipients: comparison to men awaiting transplant

Cited by 11 publications

References 10 publications

Improved erectile function and sex hormone profiles in male Chinese recipients of kidney transplantation

Improved erectile function and sex hormone profiles in male Chinese recipients of kidney transplantation

Sexual Function: A Comparison Between Male Renal Transplant Recipients and Hemodialysis Patients

Phosphodiesterase Type 5 Inhibitor Treatment for Erectile Dysfunction in Patients with End-Stage Renal Disease Receiving Dialysis or After Renal Transplantation

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