Males With Down’s Syndrome and Nonneurogenic Neurogenic Bladder

Handel, Liann N.; Barqawi, Albaha; Checa, Giancarlo; Furness, Peter D.; Koyle, Martin A.

doi:10.1016/s0022-5347(05)63983-3

Cited by 33 publications

(35 citation statements)

References 13 publications

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“…However, the underlying psychological disturbances were not recognized in the syndrome as reported by Allan (Allan ,1977). Non neurogenic-neurogenic syndrome in association with trisomy 21 was first identified by Handel et al who reviewed 26 children with DS (all boys) and found higher incidence of NNB compare to other urological abnormalities in DS (Handel et al, 2003). Hicks et al reported the first women with NNB associated with DS and also found higher incidence of NNB cases in trisomy 21 (Hicks et al, 2007).…”

Section: Historical Notementioning

confidence: 99%

“…In addition, simple renal cysts were also found in 7 of 124 cases (5.6%). Anomalies in ureteral structure has also been identified in DS (Ariel et al, 1991;Kravtzova et al, 1975;Handel et al, 2003). The incidence of obstructed megaureter or hydroureteronephrosis was reported in 2 of 124 cases (1.6%), while ureteral atresia was seen in 1 of 124 cases (0.8%) (Ariel et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

“…Down syndrome (DS), the most common chromosomal abnormality with a prevalence of 1 case per 600 live births (Dennis & Marder,2001), has many manifestations that can affect multiple organ systems (American Academy of Pediatrics Comittee on Genetics, 2001; Kallen et al, 1996) including urological abnormalities which have been recognized throughout urinary tract (Ariel et al, 1991;Berg et al,1960;Ahmed, 1990;Kravtzova et al, 1975;Handel et al, 2003;Kupferman et al, 1996;Bielek et al, 1996;Narashiman & Gupta, 2004;Koksal et al, 2003;Lang et al, 1987;Paulozzi et al, 1997). The extra copy of chromosome 21 has been suggested as an actor underlying the accompanied phenotypic abnormalities in the syndrome (Lejeune, 1959).…”

Section: Introductionmentioning

confidence: 99%

“…The incidence of obstructed megaureter or hydroureteronephrosis was reported in 2 of 124 cases (1.6%), while ureteral atresia was seen in 1 of 124 cases (0.8%) (Ariel et al, 1991). In addition, vesicoureteral reflux (Kravtzova et al, 1975), ureterovesical junction and ureteropelvic junction obstructions have also been described in patients with trisomy 21 (Handel et al, 2003). Trisomy 21 is one of genetic disorders that can also be accompanied by some urological abnormalities in lower urinary tract.…”

Section: Introductionmentioning

confidence: 99%

“…Non-neurogenic neurogenic bladder (NNB) has been reported as a functional lower urinary tract abnormality seen in DS. Handel et al retrospectively reviewed 26 patients with trisomy 21 and found 4 patients (15.4%) with NNB (Handel et al, 2003). Posterior urethral valve has also been identified in patients with trisomy 21 (Bielek et al, 1996;Narashiman & Gupta, 2004;Koksal et al, 2003;Lang DJ et al, 1987 (Bielek et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Dysfunctional Voiding of Non-Neurogenic Neurogenic Bladder: A Urological Disorder Associated with Down Syndrome

Seki¹,

Shahab²

2011

Genetics and Etiology of Down Syndrome

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Section: Historical Notementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dysfunctional Voiding of Non-Neurogenic Neurogenic Bladder: A Urological Disorder Associated with Down Syndrome

Seki¹,

Shahab²

2011

Genetics and Etiology of Down Syndrome

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Advanced Sensoring Technologies for Evaluation and Management of Lower Urinary Tract Symptoms

Gong

Ding

Jiao

et al. 2023

Advanced Sensor Research

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Nowadays, urination dysfunction caused by lower urinary tract symptoms (LUTS) has been a nonnegligible issue owing to its influences on patients’ physical and mental health, and in particular, the detection of the urination process and analysis of the urine samples of the patients have been the priority for diagnosis and treatment of LUTS. In this article, the existing perception of LUTS, such as the etiologies of LUTS and current approaches for LUTS evaluation in the clinic, is systematically summarized. Furthermore, several novels lower urinary tract (LUT) status‐sensing systems used for monitoring physiological indexes, including intravesical pressure, urine flow rate, residue urine volume, bladder volume, and biomarkers in urine, are introduced. It is believed that this presentation will make a contribution to deepening the comprehension of LUTS and promote the development of rapid, accurate, and convenient LUT testing techniques.

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Evaluation of lower urinary tract symptoms in children with Down syndrome: A prospective, case‐controlled cohort study

Kızılay

İrer

Kızılay

et al. 2020

Neurourology and Urodynamics

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Aims: In children with Down syndrome (DS) which causes cognitive impairment and intellectual disability (ID), dysfunctional voiding is proposed to be more common than in the normal population. In this study, we aimed to compare the voiding symptoms of DS children with a control group by validated questionnaires.Methods: Thirty-seven DS children without any previous urological complaints and 59 non-DS healthy children as control group was included in the study.Overactive bladder symptoms and dysfunctional voiding were evaluated with validated Overactive Bladder Questionnaire (OAB-V8) and Dysfunctional Voiding Symptom Score (DVSS) questionnaire, respectively. Data were arranged, descriptive and comparative statistical analysis were performed. Results: Demographic data of the two groups were similar except age of completing toilet training being higher in DS group. Total OAB-V8 and DVSS scores were significantly higher in the DS group. The mean scores of questions regarding voiding frequency, urgency and urgency incontinence in OAB-V8 were significantly higher in the DS group. The mean daytime incontinence, urgency, urgency incontinence, and quality of life scores in the DVSS were also significantly higher in the DS group.Conclusions: DS children have more frequent dysfunctional voiding than the normal population. ID of these children may prevent the expression of these symptoms. Awareness and early detection of these symptoms are crucial to prevent devastating complications such as renal failure. Therefore, validated questionnaires are simple, useful, and noninvasive methods. K E Y W O R D S Down syndrome, dysfunctional voiding, dysfunctional voiding symptom score, overactive bladder questionnaire, urinary incontinence Abbreviations: DS, Down syndrome; DVSS, Dysfunctional Voiding Symptom Score; ID, intellectual disability; IQ, intelligence quotient; LUTS, lower urinary tract symptoms; OAB-V8, Overactive Bladder Questionnaire; QoL, quality of life.

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Males With Down’s Syndrome and Nonneurogenic Neurogenic Bladder

Cited by 33 publications

References 13 publications

Dysfunctional Voiding of Non-Neurogenic Neurogenic Bladder: A Urological Disorder Associated with Down Syndrome

Dysfunctional Voiding of Non-Neurogenic Neurogenic Bladder: A Urological Disorder Associated with Down Syndrome

Advanced Sensoring Technologies for Evaluation and Management of Lower Urinary Tract Symptoms

Evaluation of lower urinary tract symptoms in children with Down syndrome: A prospective, case‐controlled cohort study

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